Functional interaction between macrophages and hepatocytes dictate the outcome of liver fibrosis

Autor: Kanaga Sabapathy, Christian Krueger, Dan Li, Ren Hui Chia, Fanny Xueting Teo, Min Xie

Publikováno v: Life Science Alliance

Xie et al demonstrate opposite outcomes on liver fibrosis due to deletion of c-Jun in hepatocytes alone or along with Kupffer cells, highlighting the functional interaction between these cell types in regulating the fibrotic process, dictated by c-Ju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1641ff0f593a3fb016216c9adf93ea4
https://doi.org/10.26508/lsa.202000803

Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis

Autor: Gaëlle Bougeard, Ren Hui Chia, Peh Yean Cheah, Kanaga Sabapathy, Choong Leong Tang, Beng Hooi Phang, Rashidah Othman, Thierry Frebourg

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (46), pp.E6349-E6358. ⟨10.1073/pnas.1510043112⟩

Whereas most mutations in p53 occur in the DNA-binding domain and lead to its functional inactivation, their relevance in the amino-terminal transactivation domain is unclear. We show here that amino-terminal p53 (ATp53) mutations often result in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507304d7272ab6e98a6f677663eed494
https://hal-normandie-univ.archives-ouvertes.fr/hal-02356393