Zobrazeno 1 - 10
of 456
pro vyhledávání: '"Ren‐Shan Ge"'
Autor:
Huiqian Chen, Sailing Chen, Yunbing Tang, Yingfen Ying, Shaowei Wang, Yang Zhu, Yiyan Wang, Ren-shan Ge, Ping Duan
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 290, Iss , Pp 117529- (2025)
Dicarboximide fungicides, including captafol, captan, cyclohexylthiophthalimide, folpet, and procymidone, represent a distinct category of fungicides. 17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) catalyzes the conversion of estrone to estradiol in
Externí odkaz:
https://doaj.org/article/304c273b453942aca2d7b380143c2737
Autor:
Hang Lin, Ming Su, He Zhu, Yang Yu, Jianmin Sang, Yiyan Wang, Qiqi Zhu, Yang Zhu, Xiaoheng Li, Xingwang Li, Ren-Shan Ge, Huitao Li
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 289, Iss , Pp 117503- (2025)
This research investigated the impact of cyclopiazonic acid (CPA), a mycotoxin, on the function of progenitor Leydig cells (PLCs) in prepubertal male rats, focusing on its potential disruption of mitochondrial integrity through mitofusin 1 (MFN1) mod
Externí odkaz:
https://doaj.org/article/0f2459cbfb5d4b43b1e8a564e4202550
Autor:
Chaochao Gong, Zhuoqi Chen, Yunbing Tang, Han Lu, Sailing Chen, Yang Zhu, Ren-shan Ge, Junzhao Zhao
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 286, Iss , Pp 117244- (2024)
Aromatase (CYP19A1), a pivotal enzyme in the biosynthesis of estradiol from testosterone, is predominantly expressed in reproductive tissues including placentas. This study investigated the effects of paraben acid and nine parabens on the activity of
Externí odkaz:
https://doaj.org/article/50175f4a2f904ad495b7fb8f1cd51844
Autor:
Shaowei Wang, Han Lu, Ming Su, Jiayi He, Yunbing Tang, Yingfen Ying, Zhuoqi Chen, Qiqi Zhu, Ren-Shan Ge, Huitao Li, Xiaoheng Li
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 285, Iss , Pp 117061- (2024)
Bisphenol H (BPH) has emerged as a potential alternative to bisphenol A (BPA), which has been curtailed for use due to concerns over its reproductive and endocrine toxicity. This study investigates whether BPH exerts antiandrogenic effects by impairi
Externí odkaz:
https://doaj.org/article/c2d702cda9cb48f49b7ec88282ba1a64
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 283, Iss , Pp 116852- (2024)
Dithiocarbamates have been widely used in various industrial applications, such as insecticides (ferbam) or drug (disulfiram). This study explored the inhibitory effects of dithiocarbamates on human and rat gonadal 3β-hydroxysteroid dehydrogenases (
Externí odkaz:
https://doaj.org/article/df252a107121430586636d6d33820e6f
Autor:
Jianmin Sang, Zhongyao Ji, Huitao Li, Hong Wang, Hehua Quan, Yang Yu, Jingyun Yan, Zhixiang Mao, Yiyan Wang, Linxi Li, Ren-shan Ge, Han Lin
Publikováno v:
Environment International, Vol 190, Iss , Pp 108827- (2024)
Triclosan is a potent antibacterial compound widely used in everyday products. Whether triclosan affects Leydig cell function in adult male rats remains unknown. In this study, 0, 50, 100, or 200 mg/kg/day triclosan was gavaged to Sprague-Dawley male
Externí odkaz:
https://doaj.org/article/8c1c830780af4e758607ab19cd186dc6
Autor:
Qiqi Zhu, Shanshan Zhu, Qiyao Li, Chunnan Hu, Chengshuang Pan, Huitao Li, Yang Zhu, Xiaoheng Li, Yunbing Tang, Ren-shan Ge
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 277, Iss , Pp 116391- (2024)
Prenatal exposure to diethylhexyl phthalate (DEHP) has been linked with a decline in testosterone levels in adult male rats, but the underlying mechanism remains unclear. We investigated the potential epigenetic regulation, particularly focusing on N
Externí odkaz:
https://doaj.org/article/3e4f36cf196c458cba4698bed437344e
Autor:
Chao Wen, Huan Chen, Yunbing Tang, Hang Lin, Congcong Xu, Yingfen Ying, Yang Zhu, Xinjun Miao, Ren-shan Ge, Chao Chen, Shangqin Chen
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 273, Iss , Pp 116173- (2024)
Per- and polyfluoroalkyl (PFAS) substances are enduring industrial materials. 17β-Hydroxysteroid dehydrogenase isoform 1 (17β-HSD1) is an estrogen metabolizing enzyme, which transforms estrone into estradiol in human placenta and rat ovary. Whether
Externí odkaz:
https://doaj.org/article/b9bf683c61b1488f8584b8618d0c8e93
Autor:
Zhiang Yao, Shanhui Tao, Yingji Lai, Yang Yu, Hong Wang, Jianmin Sang, Jin Yang, Huitao Li, Xiaoheng Li, Yang Li, Yangyang Ning, Ren-shan Ge, Shijun Li
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 270, Iss , Pp 115895- (2024)
Tetrachlorobisphenol A (TCBPA), a halogenated flame retardant and endocrine disruptor, has been detected in human urine and serum. While previous research has shown its impact on the reproductive system, investigations into its mechanisms during pube
Externí odkaz:
https://doaj.org/article/d297f0e309be4ffdacaf673ec4baddff
Autor:
Xinyi Qiao, Lei Ye, Jialin Lu, Chengshuang Pan, Qianjin Fei, Yang Zhu, Huitao Li, Han Lin, Ren-shan Ge, Yiyan Wang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Curcuminoids are functional food additives, and the effect on gonadal hormone biosynthesis remains unclear. Gonads contain 3β-hydroxysteroid dehydrogenase isoforms, h3β-HSD2 (humans) and r3β-HSD1 (rats), which catalyse pregnenolone into progestero
Externí odkaz:
https://doaj.org/article/27b224bdccd3457a930d80957982c4ef