Combined CADM1 and MAL promoter methylation analysis to detect (pre-)malignant cervical lesions in high-risk HPV-positive women

Autor: Renée M Overmeer, Chris J.L.M. Meijer, Albertus T. Hesselink, J.A. Louwers, René H.M. Verheijen, Nathalie Fransen Daalmeijer, Daniëlle A.M. Heideman, Renske D.M. Steenbergen, Afra Zaal, Folkert J. van Kemenade, Johannes Berkhof, Saskia M. Wilting, Peter J.F. Snijders, W. Marchien van Baal

Publikováno v: International Journal of Cancer, 129(9), 2218-2225. Wiley-Liss Inc.
Overmeer, R M, Louwers, J A, Meijer, C J L M, van Kemenade, F J, Hesselink, A T, Daalmeijer, N F, Wilting, S M, Heideman, D A M, Verheijen, R H, Zaal, A, van Baal, W M, Berkhof, J, Snijders, P J F & Steenbergen, R D M 2011, ' Combined CADM1 and MAL promoter methylation analysis to detect (pre-)malignant cervical lesions in high-risk HPV-positive women ', International Journal of Cancer, vol. 129, no. 9, pp. 2218-2225 . https://doi.org/10.1002/ijc.25890

Given the lower specificity for high-grade cervical lesions of high-risk human papillomavirus (hrHPV) testing compared to cytology, additional triage testing for hrHPV test-positive women is needed to detect high-grade cervical lesions. Here, we test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73067ffe57c23d4f347f93922ac786f
https://doi.org/10.1002/ijc.25890

Differential effects of combined Ad5-Delta 24RGD and radiation therapy in In vitro versus In vivo models of malignant glioma

Autor: Victor W. van Beusechem, Renée M Overmeer, Paul van der Valk, Winald R. Gerritsen, Sander Idema, W. Peter Vandertop, Clemens M F Dirven, Ida H van der Meulen-Muileman, Martine L.M. Lamfers, Sharif Moeniralm, Lisette Bosscher, S. Heukelom

Publikováno v: Clinical Cancer Research, 13(24), 7451-7458. American Association for Cancer Research Inc.
Clinical Cancer Research, 13(24), 7451-8. American Association for Cancer Research Inc.
Clinical cancer research, 13(24), 7451-7458. American Association for Cancer Research Inc.
Lamfers, M L M, Idema, S, Bosscher, L, Heukelom, S, Moeniralm, S, van der Meulen-Muileman, I H, Overmeer, R M, van der Valk, P, van Beusechem, V W, Gerritsen, W R, Vandertop, W P & Dirven, C M F 2007, ' Differential effects of combined Ad5-delta 24RGD and radiation therapy in in vitro versus in vivo models of malignant glioma ', Clinical Cancer Research, vol. 13, no. 24, pp. 7451-8 . https://doi.org/10.1158/1078-0432.CCR-07-1265

Purpose: The integrin-targeted conditionally replicating adenovirus Ad5-Δ24RGD has been shown to possess strong oncolytic activity in experimental tumors and is currently being developed toward phase I clinical evaluation for ovarian cancer and mali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589b9002f50d8ec2bb710efcb854cd72
https://pure.eur.nl/en/publications/6eadd278-92ab-4cd5-943c-2ccbeb51ef32

Repression of MAL tumour suppressor activity by promoter methylation during cervical carcinogenesis

Autor: Renée M, Overmeer, Florianne E, Henken, Mariska, Bierkens, Saskia M, Wilting, Ilse, Timmerman, Chris J L M, Meijer, Peter J F, Snijders, Renske D M, Steenbergen

Publikováno v: The Journal of pathology. 219(3)

We recently identified MAL (T-lymphocyte maturation associated protein) as the most down-regulated gene in cervical oncogenesis. Here, we examined the mechanism underlying MAL silencing, its functional role in cervical carcinogenesis, and the relevan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4135e9a041d4be48df8a1bd4a7136ce5
https://pubmed.ncbi.nlm.nih.gov/19662663

Sequential gene promoter methylation during HPV-induced cervical carcinogenesis

Autor: Renée M Overmeer, Renske D.M. Steenbergen, Saskia M. Wilting, Peter J.F. Snijders, J G I van Rietschoten, A O H Nygren, Chris J.L.M. Meijer, Jan P. Schouten, A Errami, Florianne E. Henken

Publikováno v: Henken, F E, Wilting, S M, Overmeer, R M, Van Rietschoten, J G I, Nygren, A O H, Errami, A, Schouten, J P, Meijer, C J L M, Snijders, P J F & Steenbergen, R D M 2007, ' Sequential gene promoter methylation during HPV-induced cervical carcinogenesis ', British Journal of Cancer, vol. 97, no. 10, pp. 1457-1464 . https://doi.org/10.1038/sj.bjc.6604055
British Journal of Cancer, 97(10), 1457-1464. Nature Publishing Group
British Journal of Cancer

We aimed to link DNA methylation events occurring in cervical carcinomas to distinct stages of HPV-induced transformation. Methylation specific-multiplex ligation-dependent probe amplification (MS-MLPA) analysis of cervical carcinomas revealed promot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38feeac3053b0bc23b68cfea8a66d839
https://research.vumc.nl/en/publications/bd4685e0-1e02-4f7f-9dd2-048cafde8ba3

Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy

Autor: Victor W. van Beusechem, G. Johan A. Offerhaus, M. E. Craanen, Wouter H. Lamers, Renée M Overmeer, Peter J.F. Snijders, Chris J.L.M. Meijer, Theodorus B. M. Hakvoort, Winald R. Gerritsen, Daniëlle A.M. Heideman

Publikováno v: Heideman, D A M, Overmeer, R M, van Beusechem, V W, Lamers, W H, Hakvoort, T B M, Snijders, P J F, Craanen, M E, Offerhaus, G J A, Meijer, C J L M & Gerritsen, W R 2005, ' Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy ', Cancer Gene Therapy, vol. 12, no. 12, pp. 954-62 . https://doi.org/10.1038/sj.cgt.7700856
Cancer Gene Therapy, 12(12), 954-962. Nature Publishing Group
Cancer Gene Therapy, 12(12), 954-62. Nature Publishing Group
Cancer gene therapy, 12(12), 954-962. Nature Publishing Group

NK4 is an hepatocyte growth factor (HGF)-antagonist and a broad angiogenesis inhibitor. NK4 gene therapy has confirmed antitumor efficacy on cancers with intact HGF-cMET signaling pathway. However, the feasibility to treat tumors in which the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5a220a1f55e42ba38fdca748f39b38
https://research.vumc.nl/en/publications/4a6ceeb0-5581-4f88-9cd8-a8d26b8f6637