Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Renée M, Brielmann"'
Publikováno v:
Genes Dev
The proteostasis network is regulated by transcellular communication to promote health and fitness in metazoans. In Caenorhabditis elegans, signals from the germline initiate the decline of proteostasis and repression of cell stress responses at repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f76e56483067c4e12e3d0643f52f85
https://europepmc.org/articles/PMC7197353/
https://europepmc.org/articles/PMC7197353/
Autor:
Yi Fan Lin, Cole M. Haynes, Johnathan Labbadia, Renée M. Brielmann, Mário F. Neto, Richard I. Morimoto
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1481-1494 (2017)
Summary: In Caenorhabditis elegans, the programmed repression of the heat shock response (HSR) accompanies the transition to reproductive maturity, leaving cells vulnerable to environmental stress and protein aggregation with age. To identify the fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a404d93f6d60f8e24946b492f5dd9529
http://www.sciencedirect.com/science/article/pii/S2211124717314857
http://www.sciencedirect.com/science/article/pii/S2211124717314857
Autor:
Luiz G. A. Alves, Peter Winter, Leonardo N. Ferreira, Luís A. Nunes Amaral, Richard I. Morimoto, Renée M. Brielmann
Reduced motor control is one of the most frequent features associated with aging and disease. Nonlinear and fractal analyses have proved to be useful in investigating human physiological alterations with age and disease. Similar findings have not bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e861d0043842df09a1f5f1ecff2c3e09
http://arxiv.org/abs/1705.03318
http://arxiv.org/abs/1705.03318
E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response
Heat-shock factor (HSF) is the master transcriptional regulator of the heat-shock response (HSR) and is essential for stress resilience. HSF is also required for metazoan development; however, its function and regulation in this process are poorly un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928af51c6d377bdf1e127370cfc7138f
https://europepmc.org/articles/PMC5066613/
https://europepmc.org/articles/PMC5066613/
Autor:
Peter Winter, Andreia Teixeira-Castro, Nicholas P. Timkovich, Richard I. Morimoto, Helio T. Navarro, Luís A. Nunes Amaral, Renée M. Brielmann
Publikováno v:
Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The study of C. elegans has led to ground-breaking discoveries in gene-function, neuronal circuits, and physiological responses. Subtle behavioral phenotypes, however, are often difficult to measure reproducibly. We have developed an experimental and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a513905d801237c48b1abdd5d5dad2c
https://pubmed.ncbi.nlm.nih.gov/27725712
https://pubmed.ncbi.nlm.nih.gov/27725712
Autor:
Sofia Esteves, Pedro Oliveira, Renée M. Brielmann, Mário F. Neto, Andreia Teixeira-Castro, Carlos Bessa, Stéphanie Oliveira, Soosung Kang, Anabela Silva-Fernandes, Liliana Santos, Andreia Neves-Carvalho, João Bessa, Richard I. Morimoto, Patrícia Maciel, Sara Duarte-Silva, Adriana Miranda, Richard B. Silverman, Teresa Summavielle, Ana Jalles
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5880a2692bb2f883c79cba0d9041c6fc
https://europepmc.org/articles/PMC4731417/
https://europepmc.org/articles/PMC4731417/
Autor:
Carmen I, Nussbaum-Krammer, Mário F, Neto, Renée M, Brielmann, Jesper S, Pedersen, Richard I, Morimoto
Publikováno v:
Journal of visualized experiments : JoVE. (95)
Prions are unconventional self-propagating proteinaceous particles, devoid of any coding nucleic acid. These proteinaceous seeds serve as templates for the conversion and replication of their benign cellular isoform. Accumulating evidence suggests th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f505f47a420dbfa63e92d5c4eeff9b0e
https://pubmed.ncbi.nlm.nih.gov/25591151
https://pubmed.ncbi.nlm.nih.gov/25591151
Autor:
Carmen Nussbaum-Krammer, Mário F. Neto, Renée M. Brielmann, Jesper Søndergaard Pedersen, Richard I. Morimoto
Publikováno v:
Journal of Visualized Experiments.
Prions are unconventional self-propagating proteinaceous particles, devoid of any coding nucleic acid. These proteinaceous seeds serve as templates for the conversion and replication of their benign cellular isoform. Accumulating evidence suggests th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4e0b890d706ca6b4c5e3400e48b304
https://doi.org/10.3791/52321-v
https://doi.org/10.3791/52321-v