Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Renée I, Seinstra"'
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Akademický článek
Rebalancing the motor circuit restores movement in a Caenorhabditis elegans model for TDP-43 toxicity
Autor: Mandy Koopman, Lale Güngördü, Leen Janssen, Renée I. Seinstra, Janet E. Richmond, Nathan Okerlund, René Wardenaar, Priota Islam, Wytse Hogewerf, Andre E.X. Brown, Erik M. Jorgensen, Ellen A.A. Nollen
Publikováno v: Cell Reports, Vol 43, Iss 5, Pp 114204- (2024)
Summary: Amyotrophic lateral sclerosis can be caused by abnormal accumulation of TAR DNA-binding protein 43 (TDP-43) in the cytoplasm of neurons. Here, we use a C. elegans model for TDP-43-induced toxicity to identify the biological mechanisms that l
Externí odkaz: https://doaj.org/article/59ffe124ab8347a4847a5c6cfc5bd77d
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2
Akademický článek
Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging
Autor: Georges E. Janssens, Xin-Xuan Lin, Lluís Millan-Ariño, Alan Kavšek, Ilke Sen, Renée I. Seinstra, Nicholas Stroustrup, Ellen A.A. Nollen, Christian G. Riedel
Publikováno v: Cell Reports, Vol 27, Iss 2, Pp 467-480.e6 (2019)
Summary: Aging strongly influences human morbidity and mortality. Thus, aging-preventive compounds could greatly improve our health and lifespan. Here we screened for such compounds, known as geroprotectors, employing the power of transcriptomics to
Externí odkaz: https://doaj.org/article/0f0d00ea6e6e44599aab71af29fa6f74
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3
Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform
Autor: Quentin Peter, Tuomas P. J. Knowles, Michele Vendruscolo, Renée I. Seinstra, Christopher M. Dobson, Mandy Koopman, Ellen A. A. Nollen, Michele Perni
Publikováno v: Nature protocols, 15(6), 2071-2106. Nature Publishing Group
Caenorhabditis elegans is a valuable model organism in biomedical research that has led to major discoveries in the fields of neurodegeneration, cancer and aging. Because movement phenotypes are commonly used and represent strong indicators of C. ele
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::242eaab4e98eedd497e4e2733874a25f
https://doi.org/10.1038/s41596-020-0321-9
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4
Preserving protein homeostasis prevents motor impairment in DNA Damage Response-compromised C. elegans
Autor: Wouter Huiting, Alejandra Duque-Jaramillo, Renée I. Seinstra, Harm. H. Kampinga, Ellen A.A. Nollen, Steven Bergink
To maintain genome integrity, cells rely on a complex system of DNA repair pathways and cell cycle checkpoints, together referred to as the DNA damage response (DDR). Impairments in DDR pathways are linked to cancer, but also to a wide range of degen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f022de7f032af3430b8aea55daba94b3
https://doi.org/10.1101/2021.12.22.473820
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7
Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation
Autor: Francesco A. Aprile, Michele Vendruscolo, Wytse Hogewerf, Anne Steinhof, Renée I. Seinstra, Esther Stroo, Tristan V. de Jong, Mohamad Amr Zaini, Victor Guryev, Olga Sin, Roméo Willinge Prins, Erich E. Wanker, Valerie Reinke, Ellen A. A. Nollen, Hai Hui Wang, Michelle M. Kudron, Alejandro Mata-Cabana, Celine N. Martineau, Cornelis F. Calkhoven
Publikováno v: Molecular Cell
Molecular Cell, 65(6), 1096-1108. CELL PRESS
Summary Protein aggregation is associated with age-related neurodegenerative disorders, such as Alzheimer’s and polyglutamine diseases. As a causal relationship between protein aggregation and neurodegeneration remains elusive, understanding the ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e49ac8b7e738cdd40f9553c84750cf6
https://research.rug.nl/en/publications/b07f1a85-8118-40ee-a7d2-94d002751a65
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8
Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform
Autor: Mandy, Koopman, Quentin, Peter, Renée I, Seinstra, Michele, Perni, Michele, Vendruscolo, Christopher M, Dobson, Tuomas P J, Knowles, Ellen A A, Nollen
Publikováno v: Nature protocols. 15(6)
Caenorhabditis elegans is a valuable model organism in biomedical research that has led to major discoveries in the fields of neurodegeneration, cancer and aging. Because movement phenotypes are commonly used and represent strong indicators of C. ele
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c0551ac7109e7e7ee36b565d83dbc20f
https://pubmed.ncbi.nlm.nih.gov/32433626
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9
Deep behavioural phenotyping reveals divergent trajectories of ageing and quantifies health state inC. elegans
Autor: Renée I. Seinstra, Baskaner B, Patrick Laurent, Nollen Eaa, William R Schafer, Brown Aex, Celine N. Martineau
Neurodegenerative diseases may be the cause or the consequence of an acceleration of physiological ageing. Evidence for this concept is lacking due to practical limitations of human studies. Here, we compared the processes of physiological and pathol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2369c71c9172b2c358d42aba5a0118c
https://doi.org/10.1101/555847
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10
C. elegans as a Model for Synucleinopathies and Other Neurodegenerative Diseases: Tools and Techniques
Autor: Mandy, Koopman, Renée I, Seinstra, Ellen A A, Nollen
Publikováno v: Methods in molecular biology (Clifton, N.J.). 1948
Caenorhabditis elegans is widely used to investigate biological processes related to health and disease. Multiple C. elegans models for human neurodegenerative diseases do exist, including those expressing human α-synuclein. Even though these models
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65fc39678e72b86a74292852cac902ef
https://pubmed.ncbi.nlm.nih.gov/30771173
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