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Publikováno v:
Journal of Clinical Endocrinology and Metabolism, 95(3), 994-999. Endocrine Society
Cytochrome P450c17 (P450c17) is a bifunctional enzyme necessary for the production of glucocorticoids (17-hydroxylase activity) and sex steroids (17,20-lyase activity). Isolated 17,20-lyase deficiency is a rare condition characterized by a deficient