Zobrazeno 1 - 10
of 10
pro vyhledávání: '"René St-Jacques"'
Autor:
Sébastien Gagné, Amandine Chefson, Sylvie Toulmond, Patrick Lacombe, Mélissa Arbour, Austin Chen, Dan McKay, Elizabeth Cauchon, Erich L. Grimm, Yeeman K. Ramtohul, M. David Percival, Jean-François Lévesque, Yves Ducharme, Dwight Macdonald, Yongxin Han, René St-Jacques, Robert Houle, Bruce Mackay, Jean-Pierre Falgueyret, Pierre-André Fournier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2670-2674
The design and optimization of a novel isoxazole S(1) linker for renin inhibitor is described herein. This effort culminated in the identification of compound 18, an orally bioavailable, sub-nanomolar renin inhibitor even in the presence of human pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb21bf0f8aa1b021cd6fbd529e12bdc
https://doi.org/10.1016/j.bmcl.2012.03.014
https://doi.org/10.1016/j.bmcl.2012.03.014
Publikováno v:
The Journal of Comparative Neurology. 366:717-725
In an effort to produce a canine model of basal forebrain ischemia with memory deficits, we have shown that dogs possess a medial striate artery that perfuses basal forebrain territory, homologous to the human recurrent artery of Heubner. In the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e049489a91c539b851fa6310879ea8a
https://doi.org/10.1002/(sici)1096-9861(19960318)366:4<717::aid-cne10>3.0.co
https://doi.org/10.1002/(sici)1096-9861(19960318)366:4<717::aid-cne10>3.0.co
Autor:
Mélissa Arbour, Gavin Chit Tsui, Jean-Pierre Falgueyret, Pierre-André Fournier, Yongxin Han, Michel Gallant, Patrick Lacombe, Daniel Dube, Daniel Simard, Elizabeth Cauchon, Austin Chen, Renee Aspiotis, Suzanna Liu, René St-Jacques, Christophe Mellon, Erich L. Grimm, Yeeman K. Ramtohul, Helene Juteau
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(5)
The discovery and SAR of a series of potent renin inhibitors possessing a novel 3,4-diarylpiperidine scaffold are described herein. The resulting compound 38 exhibit low nanomolar plasma renin IC(50), had a clean CYP 3A4 profile and displayed micromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bbcef3547c253b1c7b45e16084feb3
https://pubmed.ncbi.nlm.nih.gov/22325946
https://pubmed.ncbi.nlm.nih.gov/22325946
Autor:
Denis Riendeau, Jie Lan, Wanda Cromlish, Christoph Binkert, Patrick Hess, Anick Auger, Walter Fischli, Susana Liu, Beat Steiner, M. David Percival, René St-Jacques, Jennifer Harris, Sylvie Toulmond
Publikováno v:
Journal of the Renin-Angiotensin-Aldosterone System, Vol 12 (2011)
Introduction: The hypertensive double-transgenic (dTG) rat strain, expressing human renin and angiotensinogen, develops severe hypertension and organ damage and 50% of individuals die by 7 weeks of age. Here, we characterise a variation of this model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beab646a7377bffe0e829d1926e833b3
https://doaj.org/article/90ef8e6e178544eeae4cb4918a5e8df2
https://doaj.org/article/90ef8e6e178544eeae4cb4918a5e8df2
Autor:
Christopher P. Regan, Elizabeth Cauchon, Bruce Mackay, Yves Ducharme, Sylvie Toulmond, Sebastien Laliberte, Patrick Lacombe, Sébastien Gagné, M. David Percival, Daniel Dube, Jean-Pierre Falgueyret, JingQi Huang, Jean-François Lévesque, Dan McKay, Yongxin Han, René St-Jacques, Louis-Charles Campeau, Austin Chen, Hillary K. Regan, Pierre-André Fournier, Amandine Chefson, Erich L. Grimm, Robert Houle, Dwight Macdonald, Susana Liu
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(13)
An SAR campaign aimed at decreasing the overall lipophilicity of renin inhibitors such as 1 is described herein. It was found that replacement of the northern appendage in 1 with an N-methyl pyridone and subsequent re-optimization of the benzyl amide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6984bb7f944791450d3c0856db18d4c4
https://pubmed.ncbi.nlm.nih.gov/21621998
https://pubmed.ncbi.nlm.nih.gov/21621998
Autor:
Susana Liu, Nathalie Coulombe, René St-Jacques, Jacques Yves Gauthier, Jean-François Fournier, M. David Percival, Sylvie Desmarais, Wanda Cromlish, Sylvie Toulmond
Publikováno v:
Biological chemistry. 391(12)
Renin is the first enzyme in the renin-angiotensin-aldosterone system which is the principal regulator of blood pressure and hydroelectrolyte balance. Previous studies suggest that cathepsin B is the activator of the prorenin zymogen. Here, we show n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecb7a5c9bcec9f67c37d0d757bf74d5
https://pubmed.ncbi.nlm.nih.gov/20868234
https://pubmed.ncbi.nlm.nih.gov/20868234
Autor:
René St. Jacques, Walter M. St. John
Publikováno v:
Respiration physiology. 123(3)
Severe hypoxia or ischemia causes an alteration from eupnea to gasping. At body temperatures approximating 37 degrees C in vivo, the frequency of gasping is much less than that of eupnea. However in a perfused juvenile rat preparation, which is maint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e469148a134983e7f29e8f74df235e6a
https://pubmed.ncbi.nlm.nih.gov/11007988
https://pubmed.ncbi.nlm.nih.gov/11007988
Publikováno v:
Brain research. 819(1-2)
In neonates, ventilatory responses to hypoxia are 'biphasic,' with an augmentation followed by a decline. The hypoxia-induced augmentations in ventilation are attenuated and the depressions are accentuated following denervation of the peripheral chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202a297a75d0f8cfb4380767567938b6
https://pubmed.ncbi.nlm.nih.gov/10082870
https://pubmed.ncbi.nlm.nih.gov/10082870
Publikováno v:
Neurological research. 18(2)
Basal perforating vessels such as Heubner's artery are involved in various arteriopathic conditions resulting in cognitive and memory deficits. In order to evaluate if a model of focal forebrain ischemia can be obtained in dogs, a systematic study of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0882bc9eaf09e2d6903d0ffb1ce1a3b
https://pubmed.ncbi.nlm.nih.gov/9162871
https://pubmed.ncbi.nlm.nih.gov/9162871
Autor:
Marcella Funicello, Michela Novelli, Maurizio Ragni, Teresa Vottari, Cesare Cocuzza, Joaquin Soriano-Lopez, Chiara Chiellini, Federico Boschi, Pasquina Marzola, Pellegrino Masiello, Paul Saftig, Ferruccio Santini, Rene St-Jacques, Sylvie Desmarais, Nicolas Morin, Joseph Mancini, M David Percival, Aldo Pinchera, Margherita Maffei
Publikováno v:
PLoS ONE, Vol 2, Iss 8, p e683 (2007)
Growing evidences indicate that proteases are implicated in adipogenesis and in the onset of obesity. We previously reported that the cysteine protease cathepsin K (ctsk) is overexpressed in the white adipose tissue (WAT) of obese individuals. We her
Externí odkaz:
https://doaj.org/article/9900b82b32b749e2925a56a8a5d4331c