Zobrazeno 1 - 10
of 23
pro vyhledávání: '"René M. de Jong"'
Autor:
Mark A. Ashworth, Elvira Bombino, René M. de Jong, Hein J. Wijma, Dick B. Janssen, Kirsty J. McLean, Andrew W. Munro
Publikováno v:
ACS Catalysis, 12(24), 15028-15044. AMER CHEMICAL SOC
CYP105AS1 is a cytochrome P450 from Amycolatopsis orientalis that catalyzes monooxygenation of compactin to 6-epi-pravastatin. For fermentative production of the cholesterol-lowering drug pravastatin, the stereoselectivity of the enzyme needs to be i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7271774f14d5e45b6c65127419547b8d
https://doi.org/10.1021/acscatal.2c03974
https://doi.org/10.1021/acscatal.2c03974
Autor:
Tom van den Bergh, Giorgio Tamo, Alberto Nobili, Yifeng Tao, Tianwei Tan, Uwe T Bornscheuer, Remko K P Kuipers, Bas Vroling, René M de Jong, Kalyanasundaram Subramanian, Peter J Schaap, Tom Desmet, Bernd Nidetzky, Gert Vriend, Henk-Jan Joosten
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176427 (2017)
CorNet is a web-based tool for the analysis of co-evolving residue positions in protein super-family sequence alignments. CorNet projects external information such as mutation data extracted from literature on interactively displayed groups of co-evo
Externí odkaz:
https://doaj.org/article/99184a75be76410da58c9c377339d349
Publikováno v:
ACS Synthetic Biology, 11(2), 938-952. AMER CHEMICAL SOC
Deazaflavin-dependent whole-cell conversions in well-studied and industrially relevant microorganisms such as Escherichia coli and Saccharomyces cerevisiae have high potential for the biocatalytic production of valuable compounds. The artificial deaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9efc80038de4a8947c913f094be9674
https://research.rug.nl/en/publications/9ed377a7-0b50-4d6b-bff3-62c0fad29c1a
https://research.rug.nl/en/publications/9ed377a7-0b50-4d6b-bff3-62c0fad29c1a
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 9, p e1004335 (2015)
Interactions between small molecules and proteins play critical roles in regulating and facilitating diverse biological functions, yet our ability to accurately re-engineer the specificity of these interactions using computational approaches has been
Externí odkaz:
https://doaj.org/article/18fc03cd8cb746cb840685fb5106c77a
Autor:
Jack Maguire, Ragul Gowthaman, Marion F. Sauer, Georg Kuenze, Tanja Kortemme, Benjamin Basanta, Indigo Chris King, Jens Meiler, Rhiju Das, Ora Schueler-Furman, Nicholas A. Marze, Brandon Frenz, Christoffer Norn, Julia Koehler Leman, Jason W. Labonte, Kala Bharath Pilla, Lei Shi, Sergey Lyskov, Brian D. Weitzner, Nir London, Karen R. Khar, Jaume Bonet, Nawsad Alam, Andreas Scheck, Alexander M. Sevy, Lars Malmström, Thomas Huber, Christopher Bystroff, Lior Zimmerman, Lorna Dsilva, Bruno E. Correia, Roland L. Dunbrack, Sergey Ovchinnikov, Rocco Moretti, Scott Horowitz, Phil Bradley, Frank DiMaio, Noah Ollikainen, Brian Kuhlman, Jeffrey J. Gray, Melanie L. Aprahamian, Andrew Leaver-Fay, Santrupti Nerli, Brian Koepnick, Xingjie Pan, Manasi A. Pethe, Andrew M. Watkins, Summer B. Thyme, Enrique Marcos, Vikram Khipple Mulligan, Hahnbeom Park, Po-Ssu Huang, David K. Johnson, Daniel-Adriano Silva, Patrick Barth, Shannon Smith, Caleb Geniesse, Jason K. Lai, Patrick Conway, Amelie Stein, Jeliazko R. Jeliazkov, David Baker, Dominik Gront, Kalli Kappel, Firas Khatib, Robert Kleffner, Brian J. Bender, Richard Bonneau, Kyle A. Barlow, Joseph H. Lubin, Shourya S. Roy Burman, Nikolaos G. Sgourakis, Yuval Sedan, Ryan E. Pavlovicz, Kristin Blacklock, Seth Cooper, Barak Raveh, Alisa Khramushin, John Karanicolas, Justin B. Siegel, Sharon L. Guffy, Brian G. Pierce, Alex Ford, Darwin Y. Fu, Orly Marcu, Gideon Lapidoth, Brian Coventry, René M. de Jong, Shane O’Conchúir, Thomas W. Linsky, William R. Schief, Rebecca F. Alford, Scott E. Boyken, Sagar D. Khare, Maria Szegedy, Ray Yu-Ruei Wang, Steven M. Lewis, Hamed Khakzad, Timothy M. Jacobs, Frank D. Teets, Lukasz Goldschmidt, Daisuke Kuroda, Steffen Lindert, P. Douglas Renfrew, Yifan Song, Jared Adolf-Bryfogle, Michael S. Pacella, Aliza B. Rubenstein
Publikováno v:
Nat Methods
The Rosetta software for macromolecular modeling, docking and design is extensively used in laboratories worldwide. During two decades of development by a community of laboratories at more than 60 institutions, Rosetta has been continuously refactore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c561276e840d68005d2aab06fb9642da
https://pubmed.ncbi.nlm.nih.gov/32483333
https://pubmed.ncbi.nlm.nih.gov/32483333
Autor:
Daniel Mink, Yan Duan, René M. de Jong, Zhanglin Lin, Xianxing Gao, Lina Ba, Dunming Zhu, Iwona Kaluzna, Jianwei Gao
Publikováno v:
Applied Microbiology and Biotechnology. 100:8779-8788
ω-Hydroxy oleic acid is an important intermediate for the synthesis of certain polyesters and polyamides. In this study, a functional CYP153A/putidaredoxin (Pdx)/putidaredoxin reductase (Pdr) hybrid system was engineered for improved ω-hydroxylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee3a0ba8a19168288150fab81a059d4
https://doi.org/10.1007/s00253-016-7634-1
https://doi.org/10.1007/s00253-016-7634-1
Autor:
Paul P. de Waal, Misun Lee, Henriëtte J. Rozeboom, René M. de Jong, Dick B. Janssen, Hanna M. Dudek
Publikováno v:
Biochemistry
Biochemistry, 56(45), 5991-6005. AMER CHEMICAL SOC
Biochemistry, 56(45), 5991-6005. AMER CHEMICAL SOC
Xylose isomerase from Piromyces sp. E2 (PirXI) can be used to equip Saccharomyces cerevisiae with the capacity to ferment xylose to ethanol. The biochemical properties and structure of the enzyme have not been described even though its metal content,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0dec451b33ffe61bcef3e74ef785181
https://pubmed.ncbi.nlm.nih.gov/29045784
https://pubmed.ncbi.nlm.nih.gov/29045784
Autor:
Jules Beekwilder, Rokus Renirie, Harro J. Bouwmeester, Dirk Bosch, Miriam Goedbloed, Adèle van Houwelingen, Theo Sonke, René M. de Jong, Katarina Cankar
Publikováno v:
FEBS Letters, 588(6), 1001-1007
FEBS Letters 588 (2014) 6
FEBS Letters 588 (2014) 6
(+)-Nootkatone is a natural sesquiterpene ketone used in grapefruit and citrus flavour compositions. It occurs in small amounts in grapefruit and is a major component of Alaska cedar (Callitropsis nootkatensis) heartwood essential oil. Upon co-expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de289e26a55a2b6c4233f439c3774d3
https://doi.org/10.1016/j.febslet.2014.01.061
https://doi.org/10.1016/j.febslet.2014.01.061
Autor:
Yoon Jae Kim, Hector Serrano, Elizabeth A. Burks, Gerrit J. Poelarends, Andy-Mark W. H. Thunnissen, Christian P. Whitman, William H. Johnson, Bauke W. Dijkstra, René M. de Jong, Paola Bazzacco
Publikováno v:
Journal of Biological Chemistry. 282:2440-2449
The bacterial degradation pathways for the nematocide 1,3-dichloropropene rely on hydrolytic dehalogenation reactions catalyzed by cis- and trans-3-chloroacrylic acid dehalogenases (cis-CaaD and CaaD, respectively). X-ray crystal structures of native
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5deed9c9976e9b5458280762da16fea6
https://doi.org/10.1074/jbc.m608134200
https://doi.org/10.1074/jbc.m608134200
Autor:
Paul P. de Waal, Arnold J. M. Driessen, René M. de Jong, Jeroen G. Nijland, Paul Klaassen, Hyun Yong Shin
Publikováno v:
Biotechnology for Biofuels, 8(176). BioMed Central Ltd.
Biotechnology for Biofuels
Biotechnology for Biofuels
Background The yeast Saccharomyces cerevisiae is unable to ferment pentose sugars like d-xylose. Through the introduction of the respective metabolic pathway, S. cerevisiae is able to ferment xylose but first utilizes d-glucose before the d-xylose ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c1fc1339a00473e8e2ce205b0f67e7
https://doi.org/10.1186/s13068-015-0360-6
https://doi.org/10.1186/s13068-015-0360-6