Zobrazeno 1 - 10
of 20
pro vyhledávání: '"René Keil"'
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112031- (2023)
Summary: Plakophilin 3 (PKP3) is a component of desmosomes and is frequently overexpressed in cancer. Using keratinocytes either lacking or overexpressing PKP3, we identify a signaling axis from ERK to the retinoblastoma (RB) protein and the E2F1 tra
Externí odkaz:
https://doaj.org/article/466fc7e420614bb6b11f99253dcd7331
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic and stress conditions. These functions rely on their unique structural properties, which enable them to respond to context-dependent signals and transmit them
Externí odkaz:
https://doaj.org/article/c2b3edb3f30048aea275ac827ed6218a
Publikováno v:
Journal of Cell Science.
Desmosome remodeling is crucial for epidermal regeneration, differentiation and wound healing. It is mediated by adapting the composition and by posttranslational modifications of constituent proteins. We have previously demonstrated that plakophilin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2546b962dc4dff055cc9b2970076935
https://doi.org/10.1242/jcs.238295
https://doi.org/10.1242/jcs.238295
Autor:
Markus Glass, Gerd Hause, Thomas M. Magin, Carien M. Niessen, Annika Wolf, Mechthild Hatzfeld, René Keil, Annekatrin Rother, Katrin Rietscher
Publikováno v:
Journal of Investigative Dermatology. 136:1471-1478
Desmosomes mediate strong intercellular adhesion through desmosomal cadherins that interact with intracellular linker proteins including plakophilins (PKPs) 1-3 to anchor the intermediate filaments. PKPs show overlapping but distinct expression patte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3124e5f769b4c8a7645d0639e6cd370e
https://doi.org/10.1016/j.jid.2016.03.021
https://doi.org/10.1016/j.jid.2016.03.021
Autor:
Marco Foresti, Mariya Y. Radeva, Daniela Kugelmann, Volker Spindler, Jens Waschke, Michael Fuchs, René Keil, Franziska Vielmuth, Mechthild Hatzfeld
Publikováno v:
Cellular and molecular life sciences : CMLS. 76(17)
Plakophilins (Pkp) are desmosomal plaque proteins crucial for desmosomal adhesion and participate in the regulation of desmosomal turnover and signaling. However, direct evidence that Pkps regulate clustering and molecular binding properties of desmo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfb4e2310e69910ac4526eb6432e6dd
https://pubmed.ncbi.nlm.nih.gov/30949721
https://pubmed.ncbi.nlm.nih.gov/30949721
Publikováno v:
Journal of cell science. 131(10)
Desmosomes are essential for strong intercellular adhesion and are abundant in tissues exposed to mechanical strain. At the same time, desmosomes need to be dynamic to allow for remodeling of epithelia during differentiation or wound healing. Phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593be1e4170963ca28004c166c97969c
https://pubmed.ncbi.nlm.nih.gov/29678907
https://pubmed.ncbi.nlm.nih.gov/29678907
Publikováno v:
Cell Communication & Adhesion. 21:25-42
The regulation of adhesion and growth is important for epithelial function and dysfunction. β-catenin (armadillo in Drosophila) is the prototype of a multifunctional molecule that regulates cell adhesion via adherens junctions and cell signaling via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0089cbbef42746892e8e6cb39c640af9
https://doi.org/10.3109/15419061.2013.876017
https://doi.org/10.3109/15419061.2013.876017
Autor:
Stefan Hüttelmaier, Britta Qualmann, René Keil, Michael M. Kessels, Alexander Nolze, Marcell Lederer, Jacqueline Schneider, Mechthild Hatzfeld
Publikováno v:
RNA. 19:1483-1496
Loss of fragile X mental retardation protein (FMRP) causes synaptic dysfunction and intellectual disability. FMRP is an RNA-binding protein that controls the translation or turnover of a subset of mRNAs. Identifying these target transcripts is an imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f609c8d0c8fff2b959bb0836c5946761
https://doi.org/10.1261/rna.037945.112
https://doi.org/10.1261/rna.037945.112
Publikováno v:
bchm. 394:1005-1017
P0071 is a member of a subfamily of armadillo proteins that also comprises p120-catenin (p120ctn), δ-catenin/NPRAP, ARVCF and the more distantly related plakophilins 1–3. These proteins share a conserved central domain consisting of a series of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aece4119b83e61f7c8d5c94ba3f4648
https://doi.org/10.1515/hsz-2013-0114
https://doi.org/10.1515/hsz-2013-0114
Autor:
René Keil, Paul Walther, Thomas Seufferlein, Susanne Bobrovich, Marc Porzner, Alexander Becher, Mechthild Hatzfeld, Tim Eiseler
Publikováno v:
Journal of cell science. 130(19)
We here report a novel function of the armadillo protein p0071 (also known as PKP4) during transport mediated by the KIF3 transport complex. Secretion of chromogranin A and matrix metallopeptidase 9 from pancreatic neuroendocrine tumor cells or pancr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8f71cea976b0b380f6040b0a90532d
https://pubmed.ncbi.nlm.nih.gov/28808088
https://pubmed.ncbi.nlm.nih.gov/28808088