Zobrazeno 1 - 10
of 89
pro vyhledávání: '"René Houtman"'
Autor:
Eva M. G. Viho, A. Mattijs Punt, Ben Distel, René Houtman, Jan Kroon, Ype Elgersma, Onno C. Meijer
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 303 (2022)
Angelman Syndrome (AS) is a severe neurodevelopmental disorder, caused by the neuronal absence of the ubiquitin protein ligase E3A (UBE3A). UBE3A promotes ubiquitin-mediated protein degradation and functions as a transcriptional coregulator of nuclea
Externí odkaz:
https://doaj.org/article/80a30159b50a493fa528cb72e29558ba
Autor:
Marjoleine F. Broekema, Maarten P.G. Massink, Cinzia Donato, Joep de Ligt, Joerg Schaarschmidt, Anouska Borgman, Marieke G. Schooneman, Diana Melchers, Martin N. Gerding, René Houtman, Alexandre M.J.J. Bonvin, Amit R. Majithia, Houshang Monajemi, Gijs W. van Haaften, Maarten R. Soeters, Eric Kalkhoven
Publikováno v:
Molecular Metabolism, Vol 20, Iss , Pp 115-127 (2019)
Objective: The nuclear receptor PPARγ is the master regulator of adipocyte differentiation, distribution, and function. In addition, PPARγ induces terminal differentiation of several epithelial cell lineages, including colon epithelia. Loss-of-func
Externí odkaz:
https://doaj.org/article/53f1ce77e920425c99f8b77ad47374db
Autor:
Anne Gallez, Silvia Blacher, Erik Maquoi, Erika Konradowski, Marc Joiret, Irina Primac, Céline Gérard, Mélanie Taziaux, René Houtman, Liesbet Geris, Françoise Lenfant, Elisabetta Marangoni, Nor Eddine Sounni, Jean-Michel Foidart, Agnès Noël, Christel Péqueux
Publikováno v:
Cancers, Vol 13, Iss 10, p 2486 (2021)
Given the unequivocal benefits of menopause hormone therapies (MHT) and combined oral contraceptives (COC), there is a clinical need for new formulations devoid of any risk of breast cancer promotion. Accumulating data from preclinical and clinical s
Externí odkaz:
https://doaj.org/article/89a53d1553e94e11bb4fa17476a885f0
Autor:
Federico Monczor, Antonia Chatzopoulou, Carlos Daniel Zappia, René Houtman, Onno C. Meijer, Carlos P. Fitzsimons
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Regulatory factors that control gene transcription in multicellular organisms are assembled in multicomponent complexes by combinatorial interactions. In this context, nuclear receptors provide well-characterized and physiologically relevant systems
Externí odkaz:
https://doaj.org/article/ddcd2ab820bd4a54abee1063480641d1
Autor:
Sean W Fanning, Rinath Jeselsohn, Venkatasubramanian Dharmarajan, Christopher G Mayne, Mostafa Karimi, Gilles Buchwalter, René Houtman, Weiyi Toy, Colin E Fowler, Ross Han, Muriel Lainé, Kathryn E Carlson, Teresa A Martin, Jason Nowak, Jerome C Nwachukwu, David J Hosfield, Sarat Chandarlapaty, Emad Tajkhorshid, Kendall W Nettles, Patrick R Griffin, Yang Shen, John A Katzenellenbogen, Myles Brown, Geoffrey L Greene
Publikováno v:
eLife, Vol 7 (2018)
Acquired resistance to endocrine therapy remains a significant clinical burden for breast cancer patients. Somatic mutations in the ESR1 (estrogen receptor alpha (ERα)) gene ligand-binding domain (LBD) represent a recognized mechanism of acquired re
Externí odkaz:
https://doaj.org/article/582b84ec644248bbb6fb9af5a9be5532
Autor:
Chandra S. Chirumamilla, Ajay Palagani, Balu Kamaraj, Ken Declerck, Marinus W. C. Verbeek, Ryabtsova Oksana, Karolien De Bosscher, Nadia Bougarne, Bart Ruttens, Kris Gevaert, René Houtman, Winnok H. De Vos, Jurgen Joossens, Pieter Van Der Veken, Koen Augustyns, Xaveer Van Ostade, Annemie Bogaerts, Hans De Winter, Wim Vanden Berghe
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC liga
Externí odkaz:
https://doaj.org/article/f904b8d98f0241f082ac224164430591
Autor:
Jerome C Nwachukwu, Sathish Srinivasan, Yangfan Zheng, Song Wang, Jian Min, Chune Dong, Zongquan Liao, Jason Nowak, Nicholas J Wright, René Houtman, Kathryn E Carlson, Jatinder S Josan, Olivier Elemento, John A Katzenellenbogen, Hai‐Bing Zhou, Kendall W Nettles
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 4, Pp n/a-n/a (2016)
Abstract Some estrogen receptor‐α (ERα)‐targeted breast cancer therapies such as tamoxifen have tissue‐selective or cell‐specific activities, while others have similar activities in different cell types. To identify biophysical determinants
Externí odkaz:
https://doaj.org/article/cf1c1a8640554626b04f8b7d235ebf06
Autor:
Jerome C Nwachukwu, Sathish Srinivasan, Nelson E Bruno, Alexander A Parent, Travis S Hughes, Julie A Pollock, Olsi Gjyshi, Valerie Cavett, Jason Nowak, Ruben D Garcia-Ordonez, René Houtman, Patrick R Griffin, Douglas J Kojetin, John A Katzenellenbogen, Michael D Conkright, Kendall W Nettles
Publikováno v:
eLife, Vol 3 (2014)
Resveratrol has beneficial effects on aging, inflammation and metabolism, which are thought to result from activation of the lysine deacetylase, sirtuin 1 (SIRT1), the cAMP pathway, or AMP-activated protein kinase. In this study, we report that resve
Externí odkaz:
https://doaj.org/article/fb4d849c2f4b408cb4639c209bbfccd2
Autor:
Eva M. G. Viho, A. Mattijs Punt, Ben Distel, René Houtman, Jan Kroon, Ype Elgersma, Onno C. Meijer
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 303
International Journal of Molecular Sciences, 24(1). MDPI
International Journal of Molecular Sciences, 24(1):303. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 24(1). MDPI
International Journal of Molecular Sciences, 24(1):303. Multidisciplinary Digital Publishing Institute (MDPI)
Angelman Syndrome (AS) is a severe neurodevelopmental disorder, caused by the neuronal absence of the ubiquitin protein ligase E3A (UBE3A). UBE3A promotes ubiquitin-mediated protein degradation and functions as a transcriptional coregulator of nuclea
Autor:
Laura Van Moortel, Annick Verhee, René Houtman, Diana Melchers, Louis Delhaye, Jonathan Thommis, Kris Gevaert, Sven Eyckerman, Karolien De Bosscher
Exogenous glucocorticoids are frequently used to treat inflammatory disorders and as adjuncts for treatment of solid cancers. However, their use is associated with severe side effects and therapy resistance. Novel glucocorticoid receptor (GR) ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::902604cc3fd0d958726ae60b7dab583c
https://doi.org/10.1101/2023.05.15.540854
https://doi.org/10.1101/2023.05.15.540854