Zobrazeno 1 - 10
of 272
pro vyhledávání: '"René Holm"'
Autor:
Sarah Lindsay, Olympia Tumolva, Tatsiana Khamiakova, Hans Coppenolle, Martin Kovarik, Sanket Shah, René Holm, Yvonne Perrie
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1159 (2024)
Microfluidic liposome production presents a streamlined pathway for expediting the translation of liposomal formulations from the laboratory setting to clinical applications. Using this production method, resultant liposome characteristics can be tun
Externí odkaz:
https://doaj.org/article/9ef5e5d2ecb748f3b94b701c41824cd0
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1909 (2023)
Dissolution limitations to oral absorption can occur if the time required for dissolution is longer than the transit time across the small intestine and/or if dissolution is slower than the drug’s permeation through the gut wall. These limitations
Externí odkaz:
https://doaj.org/article/f6ffb8b65cfb4371bf4d03ce21b50a2a
Autor:
Rasmus Blaaholm Nielsen, René Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 283 (2023)
P-glycoprotein (P-gp) limits the oral absorption of drug substances. Potent small molecule P-gp inhibitors (e.g., zosuquidar) and nonionic surfactants (e.g., polysorbate 20) inhibit P-gp by proposedly different mechanisms. Therefore, it was hypothesi
Externí odkaz:
https://doaj.org/article/a46f314b76934509a5e5f8a426054059
Autor:
Rasmus Blaaholm Nielsen, René Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100089- (2021)
P-glycoprotein inhibitors, like zosuquidar, have widely been used to study the role of P-glycoprotein in oral absorption. Still, systematic studies on the inhibitor dose-response relationship on intestinal drug permeation are lacking. In the present
Externí odkaz:
https://doaj.org/article/a7a961e60a9f42388fa54a007c5b264b
Publikováno v:
FEBS Open Bio, Vol 9, Iss 6, Pp 1071-1081 (2019)
Nuclear factor of activated T cells 5 (NFAT5) is a transcription factor involved in the regulation of several genes involved in the response to extracellular hyperosmolality. Recently, the uptake of ibuprofen by an as yet unknown carrier was suggeste
Externí odkaz:
https://doaj.org/article/c85ba85a8bab4f54ac31d4beb8a8c5d8
Autor:
Fiona Macintyre, Hanu Ramachandruni, Jeremy N. Burrows, René Holm, Anna Thomas, Jörg J. Möhrle, Stephan Duparc, Rob Hooft van Huijsduijnen, Brian Greenwood, Winston E. Gutteridge, Timothy N. C. Wells, Wiweka Kaszubska
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-18 (2018)
Abstract Over the last 15 years, the majority of malaria drug discovery and development efforts have focused on new molecules and regimens to treat patients with uncomplicated or severe disease. In addition, a number of new molecular scaffolds have b
Externí odkaz:
https://doaj.org/article/dbdcceb481fa497fa620c83328de23ba
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 13, Iss 6, Pp 507-517 (2018)
Parkinson's disease (PD) is a chronic debilitating disease affecting approximately 1% of the population over the age of 60. The severity of PD is correlated to the degree of dopaminergic neuronal loss. Apomorphine has a similar chemical structure as
Externí odkaz:
https://doaj.org/article/53e04430893b45ce95f35101a19d6852
Autor:
Laura J. Henze, Niklas J. Koehl, Joseph P. O'Shea, René Holm, Maria Vertzoni, Brendan T. Griffin
Publikováno v:
International Journal of Pharmaceutics: X, Vol 1, Iss , Pp - (2019)
A preclinical porcine model that reliably predicts human food effect of fenofibrate was developed. Fenofibrate was administered to pigs as model compound with a positive food effect. Two different types of fed conditions were explored: a FDA style br
Externí odkaz:
https://doaj.org/article/b0e53c7d835c4cd195b7ef88274c3811
Autor:
Sandy Van Hemelryck, Jonatan Dewulf, Harm Niekus, Marjolein van Heerden, Benno Ingelse, René Holm, Erik Mannaert, Peter Langguth
Publikováno v:
International Journal of Pharmaceutics: X, Vol 1, Iss , Pp - (2019)
The objective of this study was to evaluate in vitro and in vivo drug release from in situ forming gels prepared with poloxamer 338 (P338) and/or 407 (P407) in N-methyl-2-pyrrolidone (NMP)/water mixtures for the model compound bedaquiline fumarate sa
Externí odkaz:
https://doaj.org/article/2b4dd4a7e7ba43d2bc553d923546c1c7
Autor:
Harriet Bennett-Lenane, Joseph P. O’Shea, Jack D. Murray, Alexandra-Roxana Ilie, René Holm, Martin Kuentz, Brendan T. Griffin
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1398 (2021)
In response to the increasing application of machine learning (ML) across many facets of pharmaceutical development, this pilot study investigated if ML, using artificial neural networks (ANNs), could predict the apparent degree of supersaturation (a
Externí odkaz:
https://doaj.org/article/7b06bc13a1894a9ba8b0eaab5f9147a4