In vitro alternative for reactogenicity assessment of outer membrane vesicle based vaccines

Autor: Marijke W. A. Molenaar-de Backer, Paulien Doodeman, Fereshte Rezai, Lisa M. Verhagen, Arno van der Ark, Els M. Plagmeijer, Bernard Metz, Naomi van Vlies, Olga Ophorst, René H. M. Raeven

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Intrinsic or added immune activating molecules are key for most vaccines to provide desired immunity profiles but may increase systemic reactogenicity. Regulatory agencies require rabbit pyrogen testing (RPT) for demonstration of vaccine rea

Externí odkaz: https://doaj.org/article/e4e7d7d3c4fe4e64adcffc572b4ed1ec

Antibody Specificity Following a Recent Bordetella pertussis Infection in Adolescence Is Correlated With the Pertussis Vaccine Received in Childhood

Autor: René H. M. Raeven, Larissa van der Maas, Jeroen L. A. Pennings, Kurt Fuursted, Charlotte Sværke Jørgensen, Elly van Riet, Bernard Metz, Gideon F. A. Kersten, Tine Dalby

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Bordetella (B.) pertussis resurgence affects not only the unvaccinated, but also the vaccinated population. Different vaccines are available, however, it is currently unknown whether the type of childhood vaccination has an influence on antibody resp

Externí odkaz: https://doaj.org/article/85d64f10d26e4dd2aac31e2d0aad2f2f

Meta-Analysis of Pulmonary Transcriptomes from Differently Primed Mice Identifies Molecular Signatures to Differentiate Immune Responses following Bordetella pertussis Challenge

Autor: René H. M. Raeven, Jeroen L. A. Pennings, Elly van Riet, Gideon F. A. Kersten, Bernard Metz

Publikováno v: Journal of Immunology Research, Vol 2017 (2017)

Respiratory infection with Bordetella pertussis leads to severe effects in the lungs. The resulting immunity and also immunization with pertussis vaccines protect against disease, but the induced type of immunity and longevity of the response are dis

Externí odkaz: https://doaj.org/article/a606b2cd30da472f9e1c47d1debc6380

Systems vaccinology and big data in the vaccine development chain

Autor: Gideon F.A. Kersten, Bernard Metz, René H. M. Raeven, Hugo D. Meiring, Elly van Riet

Publikováno v: Immunology, 156(1), 33-46
Immunology

Summary Systems vaccinology has proven a fascinating development in the last decade. Where traditionally vaccine development has been dominated by trial and error, systems vaccinology is a tool that provides novel and comprehensive understanding if p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f9823b5ff358c3b458294e9fb23fbb
http://hdl.handle.net/1887/69900

Development of a thermostable spray dried outer membrane vesicle pertussis vaccine for pulmonary immunization

Autor: Peter C. Soema, Elly van Riet, Jean-Pierre Amorij, Gaurav Kanojia, Larissa van der Maas, Henderik W. Frijlink, René H. M. Raeven, Tim H E Bindels, Rimko ten Have, Gideon F.A. Kersten, Bernard Metz

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society, 286, 167-178. Elsevier Bedrijfsinformatie b.v.
Journal of Controlled Release, 286, 167-178
Journal of Controlled Release

Worldwide resurgence of whooping cough calls for improved, next-generation pertussis vaccines that induce broad and long-lasting immunity. A mucosal pertussis vaccine based on outer membrane vesicles (omvPV) is a promising candidate. Further, a vacci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2d59e9da910968f7f44b23f42dbd5f
https://research.rug.nl/en/publications/a36938c5-f9fa-4ef2-ad76-2b13a2cb2167