Zobrazeno 1 - 10
of 347
pro vyhledávání: '"René Grée"'
Autor:
Battini Veeraiah, Kishore Ramineni, Dabbugoddu Brahmaiah, Nangunoori Sampath Kumar, Hélène Solhi, Rémy Le Guevel, Chada Raji Reddy, Frédéric Justaud, René Grée
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 2592-2598 (2024)
In this paper, we report a short and efficient synthesis of novel N-arylbenzo[h]quinazoline-2-amines. We have prepared a focused library of nineteen representative examples which have been submitted to cytotoxicity assays against a representative pan
Externí odkaz:
https://doaj.org/article/c0156c58495f466e9f62d5f36cb9d362
Publikováno v:
Journal of Saudi Chemical Society, Vol 23, Iss 8, Pp 1049-1059 (2019)
Oleuropein is the major phenolic compound extracted from olive leaves and it is also present in olive fruits and virgin olive oil. It has already demonstrated a wide range of pharmacological activities, but new derivatives have to be designed in orde
Externí odkaz:
https://doaj.org/article/001c95c3c1c747c9b1786bc03bb5b1c1
Structure Activity Relationship Studies around DB18, a Potent and Selective Inhibitor of CLK Kinases
Autor:
Dabbugoddu Brahmaiah, Anagani Kanaka Durga Bhavani, Pasula Aparna, Nangunoori Sampath Kumar, Hélène Solhi, Rémy Le Guevel, Blandine Baratte, Thomas Robert, Sandrine Ruchaud, Stéphane Bach, Surender Singh Jadav, Chada Raji Reddy, Paul Mosset, Nicolas Gouault, Nicolas Levoin, René Grée
Publikováno v:
Molecules, Vol 27, Iss 19, p 6149 (2022)
Three series of our lead CLK1 inhibitor DB18 have been designed, synthetized and tested against CLKs and DYRK1A kinases. Their cytotoxicity was subsequently measured on seven representative cancer cell lines. Guided by docking experiments, we focused
Externí odkaz:
https://doaj.org/article/8f6310fc059c4f1d98e8bd66d3c3586f
Autor:
Abeer J. Ayoub, Layal Hariss, Nehme El-Hachem, Ghewa A. El-Achkar, Sandra E. Ghayad, Oula K. Dagher, Nada Borghol, René Grée, Bassam Badran, Ali Hachem, Eva Hamade, Aida Habib
Publikováno v:
BMC Chemistry, Vol 13, Iss 1, Pp 1-18 (2019)
Abstract Introduction New fluorinated diaryl ethers and bisarylic ketones were designed and evaluated for their anti-inflammatory effects in primary macrophages. Methods The synthesis of the designed molecules started from easily accessible and versa
Externí odkaz:
https://doaj.org/article/84a342bf0b0e458f804a0b73c9bae9a6
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2115-2121 (2017)
Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been prepared in fair yields by the reaction of gem-difluoroenones with aminopyridines, -pyrimidines and -pyridazines. Condensed
Externí odkaz:
https://doaj.org/article/43fb7d4777094ccf91f160d510b1e994
Autor:
Assaad Nasr El Dine, Ali Khalaf, Danielle Grée, Olivier Tasseau, Fares Fares, Nada Jaber, Philippe Lesot, Ali Hachem, René Grée
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 1943-1948 (2013)
Starting from easily accessible gem-difluoropropargylic derivatives, a DBU-mediated isomerisation affords enones in fair yields with a gem-difluoroalkyl chain. These derivatives were used to prepare pyrazolines and pyrrolines with the desired gem-dif
Externí odkaz:
https://doaj.org/article/ba12495f2fd84577a917bba9c8df2a43
Publikováno v:
Organic Letters
Organic Letters, 2023, 25 (15), pp.2594-2599. ⟨10.1021/acs.orglett.3c00487⟩
Organic Letters, 2023, 25 (15), pp.2594-2599. ⟨10.1021/acs.orglett.3c00487⟩
International audience; We herein demonstrate the acylsilane-directed Rh-catalyzed arene C-H bond alkylation with maleimides. The resulting derivatives were utilized in visible-light-induced intramolecular siloxycarbene-amide cyclization for the synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ed83196d720b71f51cfb12963b0a7d
https://doi.org/10.1021/acs.orglett.3c00487
https://doi.org/10.1021/acs.orglett.3c00487
Autor:
Habib, Abeer J. Ayoub, Ghewa A. El-Achkar, Sandra E. Ghayad, Layal Hariss, Razan H. Haidar, Leen M. Antar, Zahraa I. Mallah, Bassam Badran, René Grée, Ali Hachem, Eva Hamade, Aida
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10399
Benzofuran and 2,3-dihydrobenzofuran scaffolds are heterocycles of high value in medicinal chemistry and drug synthesis. Targeting inflammation in cancer associated with chronic inflammation is a promising therapy. In the present study, we investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::430e376281b05a0588cbb4793c08d881
Autor:
Frédéric Justaud, Hippolyte Paysant, Louis Bastien Weiswald, Abdelghani Jebahi, Marie Jouanne, Nicolas Elie, Anne Sophie Voisin-Chiret, Thierry Roisnel, Clément Orione, Nicolas Levoin, Laurent Poulain, René Grée
Publikováno v:
New Journal of Chemistry
New Journal of Chemistry, 2022, 46 (19), pp.9119-9127. ⟨10.1039/D1NJ05987D⟩
New Journal of Chemistry, 2022, 46 (19), pp.9119-9127. ⟨10.1039/D1NJ05987D⟩
International audience; The development of inhibitors of anti-apoptotic proteins, such as Mcl-1, is currently a very active area in the field of cancer research. One of the very first reported inhibitor of Mcl-1 was the molecule MIM1, but we have dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f1b51b186195d87bbb6f5278d46dd5
https://doi.org/10.1039/d1nj05987d
https://doi.org/10.1039/d1nj05987d
Publikováno v:
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2023, 21, pp.1046-1055. ⟨10.1039/d2ob02025d⟩
Organic & Biomolecular Chemistry, 2023, 21, pp.1046-1055. ⟨10.1039/d2ob02025d⟩
International audience; A novel one-pot base-promoted insertion of indolyl 2-alkynes into a C-C single bond of 1,3-diketones, followed by intramolecular aldol reaction and dehydrative aromatization is described. This reaction cascade leads to the con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65786947e05953f44bb06dcb4afec768
https://hal.science/hal-03969066/document
https://hal.science/hal-03969066/document
