Zobrazeno 1 - 8 of 8 pro vyhledávání: '"René Fuertig"'
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The effects of transient receptor potential cation channel inhibition by BI 1358894 on cortico-limbic brain reactivity to negative emotional stimuli in major depressive disorder
Autor: Simone Grimm, Christian Keicher, Christian Paret, Inga Niedtfeld, Christian Beckmann, Maarten Mennes, Stefan Just, Vikas Sharma, René Fuertig, Lena Herich, Salome Mack, Claus Thamer, Christian Schultheis, Anne Weigand, Christian Schmahl, Andreas Wunder
Publikováno v: European Neuropsychopharmacology, 65, pp. 44-51
European Neuropsychopharmacology, 65, 44-51
Abnormal emotional processing in major depressive disorder (MDD) has been associated with increased activation to negative stimuli in cortico-limbic brain regions. The authors investigated whether treatment with BI 1358894, a small-molecule inhibitor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd65638ca5543ec4ba0d96d14be35f6
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3
LC–MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain
Autor: Andreas H. Luippold, Angelo Ceci, René Fuertig, Bastian Hengerer, Erwan Bezard, Sandrine Camus
Publikováno v: Bioanalysis. 8:1903-1917
Aim: The kynurenine (KYN) pathway is implicated in diseases such as cancer, psychiatric, neurodegenerative and autoimmune disorders. Measurement of KYN metabolite levels will help elucidating the involvement of the KYN pathway in the disease patholog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04372f4b809f742076b2935bba4021d0
https://doi.org/10.4155/bio-2016-0111
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4
Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase
Autor: Damiano Azzinnari, Bastian Hengerer, Hannes Sigrist, René Fuertig, Angelo Ceci, Andreas H. Luippold, Flurin Cathomas, Giorgio Bergamini, Erich Seifritz, Christopher R. Pryce, Stefano Vavassori
Publikováno v: Brain behavior and immunity
Psychosocial stress is a major risk factor for mood and anxiety disorders, in which excessive reactivity to aversive events/stimuli is a major psychopathology. In terms of pathophysiology, immune-inflammation is an important candidate, including high
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff022d7de44de3683c8828eb7a458dc0
https://doi.org/10.5167/uzh-118825
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5
Differential effects of peripheral and brain tumor necrosis factor on inflammation, sickness, emotional behavior and memory in mice
Autor: René Fuertig, Adriano Fontana, Lea Götze, Christopher R. Pryce, Jean-Charles Paterna, Elisabeth Jehli, Federica Klaus, Elisa Marzorati, Hannes Sigrist, Giorgio Bergamini, Erich Seifritz, Damiano Azzinnari, Severin Schwendener
Publikováno v: Brain behavior and immunity
Tumor necrosis factor alpha (TNF) is increased in depression and clinical-trial evidence indicates that blocking peripheral TNF has some antidepressant efficacy. In rodents, peripheral or intracerebroventricular TNF results in sickness e.g. reduced b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3c2f589e4c9c0181176328f1c63bf6
https://pubmed.ncbi.nlm.nih.gov/27515532
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6
CD40-TNF activation in mice induces extended sickness behavior syndrome co-incident with but not dependent on activation of the kynurenine pathway
Autor: René Fuertig, Manuela R. Bizzozzero, Adriano Fontana, Vanessa Hoop, Andreas H. Luippold, Andreas Mueller, Bastian Hengerer, Gregory N. Newman, Hannes Sigrist, Flurin Cathomas, Christopher R. Pryce, Angelo Ceci, Erich Seifritz
Publikováno v: Brain Behavior and Immunity
© 2015 Elsevier Inc. The similarity between sickness behavior syndrome (SBS) in infection and autoimmune disorders and certain symptoms in major depressive disorder (MDD) and the high co morbidity of autoimmune disorders and MDD constitutes some of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f229513aa43783bcdd5ced0c0b6aafa
https://pubmed.ncbi.nlm.nih.gov/26173174
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7
A novel liquid chromatography/tandem mass spectrometry method for the quantification of glycine as biomarker in brain microdialysis and cerebrospinal fluid samples within 5min
Autor: René Fuertig, Boris Ferger, Patrizia Voehringer
Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 939
Glycine is an important amino acid neurotransmitter in the central nervous system (CNS) and a useful biomarker to indicate biological activity of drugs such as glycine reuptake inhibitors (GRI) in the brain. Here, we report how a liquid chromatograph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda6a412af3ba20e32d51f04541daf7a
https://pubmed.ncbi.nlm.nih.gov/24121745
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8
EPA-1343 – Chronic psychosocial stress in mice causes neuro-immune-monoamine changes in brain and depression-relevant behaviour that is reversible by anti-inflammatory treatment
Autor: René Fuertig, Damiano Azzinnari, Christopher R. Pryce, Erich Seifritz, Angelo Ceci, Bastian Hengerer, Hannes Sigrist
Publikováno v: European Psychiatry. 29:1
Introduction Valid animal models are essential to understanding the aetio-pathophysiology of depression psychopathology and therefore its pharmacological treatment. Aims To establish a mouse model with aetiological and face validity, investigate the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aebe2c2284b5d354678e6e600f93df1c
https://doi.org/10.1016/s0924-9338(14)78558-x
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