Zobrazeno 1 - 10
of 19
pro vyhledávání: '"René Endlicher"'
Publikováno v:
Cells, Vol 12, Iss 9, p 1273 (2023)
The mitochondrial permeability transition pore (MPTP) is a calcium-dependent, ion non-selective membrane pore with a wide range of functions. Although the MPTP has been studied for more than 50 years, its molecular structure remains unclear. Short-te
Externí odkaz:
https://doaj.org/article/cf11521cb6f14a729f52484678b50c33
Autor:
René Endlicher, Pavla Křiváková, Halka Lotková, Marie Milerová, Zdeněk Drahota, Zuzana Červinková
Publikováno v:
Acta Medica, Vol 52, Iss 2, Pp 69-72 (2009)
Ca2+-induced opening of the mitochondrial permeability transition pore (MPTP) is involved in induction of apoptotic and necrotic processes. We studied sensitivity of MPTP to calcium using the model of Ca2+-induced, cyclosporine A-sensitive mitochondr
Externí odkaz:
https://doaj.org/article/75892375ad8d427cad89961dda1f7113
Publikováno v:
Drug and Chemical Toxicology. 40:448-456
Acetaminophen (APAP) hepatotoxicity is often studied in primary cultures of hepatocytes of various species, but there are only few works comparing interspecies differences in susceptibility of hepatocytes to APAP in vitro.The aim of our work was to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb48563e390af8bf413feae9837d321
https://doi.org/10.1080/01480545.2016.1255953
https://doi.org/10.1080/01480545.2016.1255953
Autor:
Zuzana Červinková, Otto Kucera, O Sobotka, Khurum Hakeem, David Rychtrmoc, René Endlicher, Z Drahota, Marjan Raad
Publikováno v:
Journal of Bioenergetics and Biomembranes. 48:363-373
A compound with promising anticancer properties, 3-bromopyruvate (3-BP) is a synthetic derivative of a pyruvate molecule; however, its toxicity in non-malignant cells has not yet been fully elucidated. Therefore, we elected to study the effects of 3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff3c044927a76e88b078b9a2bfc27ef
https://doi.org/10.1007/s10863-016-9674-8
https://doi.org/10.1007/s10863-016-9674-8
Publikováno v:
Scopus-Elsevier
Using a novel method for evaluating mitochondrial swelling (Drahota et al. 2012a) we studied the effect of calcium (Ca(2+)), phosphate (P(i)), and triiodothyronine (T(3)) on the opening of mitochondrial membrane permeability transition pore and how t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb32d09e26250164e34032ff6b12d571
https://doi.org/10.33549/physiolres.933041
https://doi.org/10.33549/physiolres.933041
Autor:
Stephan Hann, Zuzana Červinková, Georg Süss-Fink, Darina Muthna, Pavel Tomsik, Bruno Therrien, Milos Hroch, René Endlicher, Emil Rudolf, David Stíbal, Jana Cmielova, Martina Řezáčová, Stanislav Micuda
Publikováno v:
Journal of Organometallic Chemistry. 782:42-51
Dinuclear p-cymene ruthenium complexes of the type [(p-MeC6H4Pri)2Ru2(SC6H4-p-R)3]+, accessible from the reaction of p-cymene ruthenium dichloride dimer with the corresponding thiophenol and isolated in high yield as the chloride salts, were found to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af658974e985ce4244ae0237b99a06d1
https://doi.org/10.1016/j.jorganchem.2014.10.050
https://doi.org/10.1016/j.jorganchem.2014.10.050
Publikováno v:
Scopus-Elsevier
Fatty liver disease associated with obesity is an important medical problem and the mechanisms for lipid accumulation in hepatocytes are not fully elucidated yet. Recent findings indicate that mitochondria play an important role in this process. Our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfe72b17a508cbf367b3a060b51d816
https://doi.org/10.33549/physiolres.932645
https://doi.org/10.33549/physiolres.932645
Publikováno v:
Toxicology in Vitro. 24:2097-2103
Thioacetamide (TAA) is a hepatotoxin frequently used for experimental purposes which produces centrilobular necrosis after a single dose administration. In spite of the fact that oxidative stress seems to play a very important role in the mechanism o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85801572077ac49ab9d93462a0de9d72
https://doi.org/10.1016/j.tiv.2010.06.011
https://doi.org/10.1016/j.tiv.2010.06.011
Autor:
Otto Kucera, Zuzana Červinková, Tomáš Garnol, Tomáš Roušar, Halka Lotková, P Křiváková, René Endlicher
Publikováno v:
Acta Veterinaria Brno, Vol 78, Iss 4, Pp 603-613 (2009)
Acetaminophen (AAP) overdose causes severe liver injury and is the leading cause of acute liver injury in humans. The mechanisms participating in its toxic effect are glutathione depletion, oxidative stress and mitochondrial dysfunction. S-adenosylme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411aa2d8278a6a732fd3fd256a9e3706
https://actavet.vfu.cz/78/4/0603/
https://actavet.vfu.cz/78/4/0603/
Autor:
Anna Labajova, P Křiváková, René Endlicher, Tomáš Roušar, Halka Lotková, Z Drahota, Zuzana Červinková, Miroslav Červinka, Otto Kucera
Publikováno v:
Archives of Toxicology. 83:363-372
The aim of the study was to evaluate time course and dose dependence of peroxidative damage induced by tert-butyl hydroperoxide (tBHP) in rat hepatocytes cultured in suspension and in monolayer. At the lowest (0.1 mM) concentration, decrease of cytos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e895ef954487853c353599fe01741efe
https://doi.org/10.1007/s00204-008-0385-8
https://doi.org/10.1007/s00204-008-0385-8