Zobrazeno 1 - 10
of 445
pro vyhledávání: '"René E M Toes"'
Acetylated bacterial proteins as potent antigens inducing an anti-modified protein antibody response
Autor:
Tom W J Huizinga, Diane van der Woude, René E M Toes, Mikhail Volkov, Peter A van Veelen, Joanneke C Kwekkeboom, Karin A J van Schie, Arieke S B Kampstra, Anouk G van Mourik, Arnoud de Ru
Publikováno v:
RMD Open, Vol 10, Iss 3 (2024)
Objective Gut-residing bacteria, such as Escherichia coli, can acetylate their proteome under conditions of amine starvation. It is postulated that the (gut) microbiome is involved in the breach of immune tolerance to modified self-proteins leading t
Externí odkaz:
https://doaj.org/article/9c5b5041e28d4dc9a561bd66be48dfdc
Autor:
René E M Toes, Bruce W Kirkham, L A Trouw, Michelle D van den Beukel, Leonie S Taams, Catherine D Hughes, Sarah E Ryan, Kathryn J A Steel, Karin A J van Schie, Bina Menon
Publikováno v:
RMD Open, Vol 9, Iss 4 (2023)
Objective Undifferentiated, early inflammatory arthritis (EIA) can differentiate into seropositive or seronegative rheumatoid arthritis (RA), peripheral spondyloarthritis (SpA) or remain as seronegative undifferentiated inflammatory arthritis (UIA).
Externí odkaz:
https://doaj.org/article/1632d54ad26941bea5e5f23ce49f79fa
Autor:
Cornelia F Allaart, Tom W J Huizinga, René E M Toes, Hans Ulrich Scherer, Jeska K de Vries-Bouwstra, Sophie I E Liem, Sam Neppelenbroek, Cynthia M Fehres, Brigitte A Wevers
Publikováno v:
RMD Open, Vol 9, Iss 1 (2023)
Introduction Early diagnosis of systemic sclerosis (SSc) is important to start therapeutic interventions timely. Important risk factors for progression to SSc are the SSc-specific autoantibodies, of whom anti-centromere antibodies (ACA) and anti-topo
Externí odkaz:
https://doaj.org/article/b60d35cbf22c4b359a2ebf2422ce84b2
Autor:
Linda M Slot, Rochelle D Vergroesen, Priscilla F Kerkman, Ellen Staudinger, Sanne Reijm, Hugo J van Dooren, Ellen I H van der Voort, Tom W J Huizinga, René E M Toes, Hans U Scherer
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247847 (2021)
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 1% of the world population. RA is associated with the presence of autoantibodies, of which anti-citrullinated protein antibodies (ACPA) are most prominent. ACPA are produced by citru
Externí odkaz:
https://doaj.org/article/f4bdb0806e0240eab920cc577bc62025
Autor:
Sanne Willems, Daniël van der Velden, Paul H A Quax, Gert Jan de Borst, Jean-Paul P M de Vries, Frans L Moll, Johan Kuiper, René E M Toes, Saskia C A de Jager, Dominique P V de Kleijn, Imo E Hoefer, Gerard Pasterkamp, Ilze Bot
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88984 (2014)
BackgroundRecently, we have shown that intraplaque mast cell numbers are associated with atherosclerotic plaque vulnerability and with future cardiovascular events, which renders inhibition of mast cell activation of interest for future therapeutic i
Externí odkaz:
https://doaj.org/article/0ed8c556a6bf41fda5b555b8937c1fcd
Autor:
Jeroen N Stoop, Bi-Sheng Liu, Jing Shi, Diahann T S L Jansen, Martin Hegen, Tom W J Huizinga, Leendert A Trouw, René E M Toes
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102163 (2014)
ObjectiveThe immune response to post-translationally modified antigens is a key characteristic of rheumatoid arthritis. Carbamylation is such a posttranslational modification. Recently, we demonstrated that autoantibodies recognizing carbamylated pro
Externí odkaz:
https://doaj.org/article/b59842cee0e94863a8b2d99c5ea59403
Autor:
Anja J. de Jong, Inge R. Klein-Wieringa, Stefan N. Andersen, Joanneke C. Kwekkeboom, Linda Herb-van Toorn, Badelog J. E. de Lange-Brokaar, Danny van Delft, John Garcia, Wu Wei, Huub J. L. van der Heide, Yvonne M. Bastiaansen-Jenniskens, Gerjo J. V. M. van Osch, Annemarie M. Zuurmond, Vedrana Stojanovic-Susulic, Rob G. H. H. Nelissen, René E. M. Toes, Margreet Kloppenburg, Andreea Ioan-Facsinay
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-12 (2017)
Abstract Background Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the knee joint, there is c
Externí odkaz:
https://doaj.org/article/ec74ab8669fe45e4a28ab17c323dcccf
Autor:
Dirkjan van Schaardenburg, Annemarie L. Dorjée, Kulveer Mankia, Xanthe M E Matthijssen, Paul Emery, Laurette van Boheemen, Rachel Knevel, Annette H M van der Helm-van Mil, René E. M. Toes, M. Maurits, M. Verstappen, Fenne Wouters
Publikováno v:
Ann Rheum Dis
Annals of the Rheumatic Diseases, 81(1), 48-55. BMJ Publishing Group
Annals of the Rheumatic Diseases, 81(1), 48-55. BMJ PUBLISHING GROUP
Wouters, F, Maurits, M P, Van Boheemen, L, Verstappen, M, Mankia, K, Matthijssen, X M E, Dorjée, A L, Emery, P, Knevel, R, Van Schaardenburg, D, Toes, R E M & Van Der Helm-Van Mil, A H M 2022, ' Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis ', Annals of the Rheumatic Diseases, vol. 81, no. 1, pp. 48-55 . https://doi.org/10.1136/annrheumdis-2021-220546
Annals of the rheumatic diseases, 81(1), 48-55. BMJ Publishing Group
Annals of the Rheumatic Diseases, 81(1), 48-55. BMJ Publishing Group
Annals of the Rheumatic Diseases, 81(1), 48-55. BMJ PUBLISHING GROUP
Wouters, F, Maurits, M P, Van Boheemen, L, Verstappen, M, Mankia, K, Matthijssen, X M E, Dorjée, A L, Emery, P, Knevel, R, Van Schaardenburg, D, Toes, R E M & Van Der Helm-Van Mil, A H M 2022, ' Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis ', Annals of the Rheumatic Diseases, vol. 81, no. 1, pp. 48-55 . https://doi.org/10.1136/annrheumdis-2021-220546
Annals of the rheumatic diseases, 81(1), 48-55. BMJ Publishing Group
ObjectivesThe human leukocyte antigen-shared epitope (HLA-SE) alleles and smoking are the most prominent genetic and environmental risk factors for rheumatoid arthritis (RA). However, at which pre-arthritis stage (asymptomatic/symptomatic) they exert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c740441d21904dd38da4e29dcaa7eec
https://doi.org/10.1136/annrheumdis-2021-220546
https://doi.org/10.1136/annrheumdis-2021-220546
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis
Autor:
Yibo He, Changrong Ge, Àlex Moreno-Giró, Bingze Xu, Christian M. Beusch, Katalin Sandor, Jie Su, Lei Cheng, Erik Lönnblom, Christina Lundqvist, Linda M. Slot, Dongmei Tong, Vilma Urbonaviciute, Bibo Liang, Taotao Li, Gonzalo Fernandez Lahore, Mike Aoun, Vivianne Malmström, Theo Rispens, Patrik Ernfors, Camilla I. Svensson, Hans Ulrich Scherer, René E. M. Toes, Inger Gjertsson, Olov Ekwall, Roman A. Zubarev, Rikard Holmdahl
Publikováno v:
Nature communications, 14(1):691. Nature Publishing Group
Nature Communications, 14(1). NATURE PORTFOLIO
Nature Communications, 14(1). NATURE PORTFOLIO
Although elevated levels of anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA), the in vivo functions of these antibodies remain unclear. Here, we have expressed monoclonal ACPAs derived from patients with RA, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df53e1aba05f3801177a4170d89c42d
https://doi.org/10.1038/s41467-023-36257-x
https://doi.org/10.1038/s41467-023-36257-x
Publikováno v:
Nature reviews. Rheumatology. 19(1)
Glycosylation has a profound influence on protein activity and cell biology through a variety of mechanisms, such as protein stability, receptor interactions and signal transduction. In many rheumatic diseases, a shift in protein glycosylation occurs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03074410c9ac4ff8e1dce1872dce74f0
https://pubmed.ncbi.nlm.nih.gov/36418483
https://pubmed.ncbi.nlm.nih.gov/36418483