Zobrazeno 1 - 10
of 41
pro vyhledávání: '"René Breuer"'
Autor:
René Breuer, Manuel Mattheisen, Josef Frank, Bertram Krumm, Jens Treutlein, Layla Kassem, Jana Strohmaier, Stefan Herms, Thomas W. Mühleisen, Franziska Degenhardt, Sven Cichon, Markus M. Nöthen, George Karypis, John Kelsoe, Tiffany Greenwood, Caroline Nievergelt, Paul Shilling, Tatyana Shekhtman, Howard Edenberg, David Craig, Szabolcs Szelinger, John Nurnberger, Elliot Gershon, Ney Alliey-Rodriguez, Peter Zandi, Fernando Goes, Nicholas Schork, Erin Smith, Daniel Koller, Peng Zhang, Judith Badner, Wade Berrettini, Cinnamon Bloss, William Byerley, William Coryell, Tatiana Foroud, Yirin Guo, Maria Hipolito, Brendan Keating, William Lawson, Chunyu Liu, Pamela Mahon, Melvin McInnis, Sarah Murray, Evaristus Nwulia, James Potash, John Rice, William Scheftner, Sebastian Zöllner, Francis J. McMahon, Marcella Rietschel, Thomas G. Schulze
Publikováno v:
International Journal of Bipolar Disorders, Vol 6, Iss 1, Pp 1-10 (2018)
Abstract Background Disentangling the etiology of common, complex diseases is a major challenge in genetic research. For bipolar disorder (BD), several genome-wide association studies (GWAS) have been performed. Similar to other complex disorders, ma
Externí odkaz:
https://doaj.org/article/eebc34bafd184ebf9661b11b72caa06e
Autor:
Lutz Priebe, Franziska Degenhardt, Jana Strohmaier, René Breuer, Stefan Herms, Stephanie H Witt, Per Hoffmann, Rebecca Kulbida, Manuel Mattheisen, Susanne Moebus, Andreas Meyer-Lindenberg, Henrik Walter, Rainald Mössner, Igor Nenadic, Heinrich Sauer, Dan Rujescu, Wolfgang Maier, Marcella Rietschel, Markus M Nöthen, Sven Cichon
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e64035 (2013)
Large rare copy number variants (CNVs) have been recognized as significant genetic risk factors for the development of schizophrenia (SCZ). However, due to their low frequency (1∶150 to 1∶1000) among patients, large sample sizes are needed to det
Externí odkaz:
https://doaj.org/article/aa40682df3914b2a8a019f4252c725a5
Autor:
Kari M Ersland, Andrea Christoforou, Christine Stansberg, Thomas Espeseth, Manuel Mattheisen, Morten Mattingsdal, Gudmundur A Hardarson, Thomas Hansen, Carla P D Fernandes, Sudheer Giddaluru, René Breuer, Jana Strohmaier, Srdjan Djurovic, Markus M Nöthen, Marcella Rietschel, Astri J Lundervold, Thomas Werge, Sven Cichon, Ole A Andreassen, Ivar Reinvang, Vidar M Steen, Stephanie Le Hellard
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31687 (2012)
BackgroundDespite its estimated high heritability, the genetic architecture leading to differences in cognitive performance remains poorly understood. Different cortical regions play important roles in normal cognitive functioning and impairment. Rec
Externí odkaz:
https://doaj.org/article/8fc382b6d0cf4619a980614c796de04e
Autor:
Thomas E Gladwin, Eske M Derks, Genetic Risk and Outcome of Psychosis (GROUP), Marcella Rietschel, Manuel Mattheisen, René Breuer, Thomas G Schulze, Markus M Nöthen, Douglas Levinson, Jianxin Shi, Pablo V Gejman, Sven Cichon, Roel A Ophoff
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38828 (2012)
Recent studies suggest that variation in complex disorders (e.g., schizophrenia) is explained by a large number of genetic variants with small effect size (Odds Ratio ≈ 1.05-1.1). The statistical power to detect these genetic variants in Genome Wid
Externí odkaz:
https://doaj.org/article/ca40500cc0b04735989a6e79cbdfe3d2
Autor:
Peter P. Zandi, Lisa Jones, Aartjan T.F. Beekman, Christine Fraser, Andreas J. Forstner, Nese Direk, Mark Lathrop, Jesper Krogh, Merete Nordentoft, Bradley T. Webb, Yihan Li, Michael Bauer, Qingqin S. Li, Daniel J. Smith, Carsten Horn, Robert C. Thompson, René Breuer, Eli A. Stahl, David A. Collier, Richard Williamson, Boomsma, Dorret, I, Céline S. Reinbold, Laura J. Scott, Manolis Kogevinas, Jacob Lawrence, Caroline Hayward, Nicholas J. Schork, Penelope A. Lind, Wade H. Berrettini, John B. Vincent, Toni-Kim Clarke, Henry Voelzke, Stacy Steinberg, Hreinn Stefansson, Dean F. MacKinnon, Thorgeir E. Thorgeirsson, Niamh Mullins, Esben Agerbo, Rudolf Uher, Christina M. Hultman, Pamela A. F. Madden, Eva C. Schulte, Matthew Flickinger, Sebastian Zöllner, Kenneth S. Kendler, Urban Ösby, Enrique Castelao, Michael John Owen, Colm O'Dushlaine, Jens Treutlein, Joanna Hauser, Markus M. Noethen, Erin N. Smith, James McKay, Sandra Van der Auwera, Erin C. Dunn, Steven P. Hamilton, Martin Schalling, Helmut Vedder, Katherine Gordon-Smith, Fabio Rivas, Matthias Nauck, James B. Potash, Morten Mattingsdal, Ling Shen, Tim B. Bigdeli, Kimberly Chambert, Volker Arolt, Daniel L. Koller, Annelie Nordin Adolfsson, Na Cai, Nicholas G. Martin, Carlos N. Pato, Georg Homuth, Jonas Bybjerg-Grauholm, Alexander Teumer, Wesley K. Thompson, Hamel Patel, Jian Yang, Margit Burmeister, Frank Bellivier, Jodie N. Painter, Enda M. Byrne, Margarita Rivera, Nicholas John Craddock, Tatiana Foroud, Shaun Purcell, Paul D. Shilling, David Craig, Vanessa Kiyomi Ota, Michael Boehnke, Devin Absher, Stéphane Jamain, Anne Farmer, Yunpeng Wang, Ole Mors, William A. Scheftner, Jack D. Barchas, Robert Maier, Stanley J. Watson, Allan H. Young, Baptiste Couvy-Duchesne, Jakob Grove, Rick Jansen, John P. Rice, Gerome Breen, Eske M. Derks, Ingrid Melle, Tiffany A. Greenwood, Manuel Mattheisen, Bernard Ng, Edward M. Scolnick, Stefan Kloiber, Lili Milani, Yuri Milaneschi, Fermín Mayoral, Engilbert Sigurdsson, Sarah E. Medland, Wolfgang Maier, Alan F. Schatzberg, Myrna M. Weissman, Jun Li, John R. Kelsoe, Eric Jorgenson, Grant C.B. Sinnamon, Preben Bo Mortensen, Jana Strohmaier, William Byerley, Michel G. Nivard, Richard M. Myers, Evelin Mihailov, Gustavo Turecki, Benjamin S. Pickard, Ian J. Deary, Bernhard T. Baune, Marian L. Hamshere, Stephanie H. Witt, Patrick F. Sullivan, Jennifer L. Moran, Farnush Farhadi Hassan Kiadeh, Cathryn M. Lewis, Srdjan Djurovic, Ian B. Hickie, Hans J. Grabe, Helena Gaspar, Francis J. McMahon, Catherine Schaefer, Guy A. Rouleau, Sandra Meier, Derek W. Morris, Tõnu Esko, Wouter J. Peyrot, Markus Schwarz, Silviu-Alin Bacanu, Adam Wright, Melvin G. McInnis, Elaine K. Green, Douglas M. Ruderfer, Danielle Posthuma, Franziska Degenhardt, Per Qvist, Henriette N. Buttenschøn, Jolanta Lissowska, Stephan Ripke, Nicholas Bass, Giorgio Pistis, Emma M. Quinn, Shantel Weinsheimer, Howard J. Edenberg, Sintia Iole Belangero, Charles Curtis, Ashley R. Winslow, Tracy M. Air, Johannes H. Smit, Isaac S. Kohane, Wei Xu, Pamela B. Mahon, Neonila Szeszenia-Dabrowska, Gonneke Willemsen, Ivan Nikolov, Sven Cichon, Gregory E. Crawford, David M. Hougaard, E.J.C. de Geus, Klaus Berger, Evaristus A. Nwulia, Fernando S. Goes, Pablo Cervantes, Udo Dannlowski, Rolf Adolfsson, Thomas G. Schulze, Bruno Etain, Mark J. Adams, Thomas Hansen, Hugh Gurling, Fan Guo Meng, Judith A. Badner, Julien Bryois, Mateus Jose Abdalla Diniz, Rodrigo A. Bressan, Radhika Kandaswamy, Josef Frank, I. Nicol Ferrier, Bertram Mueller-Myhsok, Manuel A. R. Ferreira, Marion Leboyer, Futao Zhang, Valentina Moskvina, Patrik K. E. Magnusson, Laura M. Huckins, Douglas Blackwood, Michael Gill, Jianxin Shi, Dale R. Nyholt, Nancy L. Pedersen, André G. Uitterlinden, Henning Tiemeier, Vassily Trubetskoy, Scott D. Gordon, Ian Jones, Grant W. Montgomery, Martin Preisig, Cristiana Cruceanu, Sara A. Paciga, Lena Backlund, Abdel Abdellaoui, Andres Metspalu, Gunnar Morken, Marcus Ising, Sascha B. Fischer, Lilijana Oruc, Sian Caesar, Sarah Kittel-Schneider, Thalia C. Eley, Vihra Milanova, Thomas Werge, Andrew Heath, Katherine E. Tansey, Thomas W. Muehleisen, Jane H. Christensen, Chunyu Liu, Mikael Landén, Douglas F. Levinson, Julia Kraft, Juergen Wellmann, Coleman, Jonathan R., I, Peng Zhang, Glyn Lewis, Henning Teismann, Hamdi Mbarek, Carsten Bøcker Pedersen, Szabolcs Szelinger, Alexander Viktorin, Paul Brennan, Brenda W.J.H. Penninx, Maciej Trzaskowski, Yang Wu, Katharina Domschke, John Strauss, Hilary K. Finucane, Detelina Grozeva, Peter Holmans, Saira Saeed Mirza, Ole A. Andreassen, John I. Nurnberger, Lynsey S Hall, Till F. M. Andlauer, Sara Mostafavi, Andreas Reif, Joanna M. Biernacka, Christine Søholm Hansen, Hualin S. Xi, Stephen Newhouse, William E. Bunney, Andrew M. McIntosh, Anna Maaser, Enrico Domenici, Shyn, Stanley, I, Gail Davies, Warren W. Kretzschmar, Simone de Jong, Lucía Colodro-Conde, Pippa A. Thomson, Francis M. Mondimore, Martin Hautzinger, Cinnamon S. Bloss, Fabian Streit, James L. Kennedy, Erik Pettersson, Peter M. Visscher, Valentina Escott-Price, Donald J. MacIntyre, Johannes Schumacher, Kevin A. McGhee, Divya Mehta, Naomi R. Wray, Robert A. Schoevers, John A. Rice, Jordan W. Smoller, Anders D. Børglum, Susanne Lucae, Jorge A. Quiroz, Daniel Umbricht, Jouke-Jan Hottenga, Kari Stefansson, Marcella Rietschel, Zoltán Kutalik, Sarah E. Bergen, Paul F. O'Reilly, Amanda Dobbyn, Michael Conlon O'Donovan, Falk W. Lohoff, Caroline M. Nievergelt, David J. Porteous, Matthew Traylor, Brien P. Riley, Roy H. Perlis, J. Raymond DePaulo, Martin Alda, James A. Knowles, Cristiano Noto, Keith Matthews, Mark A. Frye, Patrick J. McGrath, Roseann E. Peterson, David St Clair, Roel A. Ophoff, William Coryell, Peter McGuffin, Andiara Calado Saloma Rodrigues, Elliot S. Gershon, Conor V. Dolan, Janice M. Fullerton, Weihua Guan, Niklas Långström, Pamela Sklar, Paul Lichtenstein, Per Hoffmann, Ary Gadelha, Alan W. McLean, Andrew McQuillin, Philip B. Mitchell, Huda Akil, Piotr M. Czerski, Michael Steffens, Hogni Oskarsson, Soumya Raychaudhuri, Marcos L. Santoro, Elisabeth B. Binder, Christel M. Middeldorp, Jose G. Para, Jurgen Del-Favero, Vishwajit L. Nimgaonkar, Peter R. Schofield, Stefan Herms, Marie Bækvad-Hansen, Andrea Pfennig, Albert M. van Hemert, Jutta Kammerer-Ciernioch, Adebayo Anjorin, Sara Paciga, William Lawson, George Kirov, Aiden Corvin, Maria Grigoroiu-Serbanescu, Marianne Giørtz Pedersen, Jonathan Marchini, Markus Leber, Maria Hipolito, Louise Frisén, Margitta Borrmann-Hassenbach, Amanda Elkin
Publikováno v:
Communications Biology
Communications biology 1(1), 163 (2018). doi:10.1038/s42003-018-0155-y
Communications Biology, Vol 1, Iss 1, Pp 1-10 (2018)
Communications biology, vol 1, iss 1
bioRxiv
de Jong, S, Diniz, M J A, Saloma, A, Gadelha, A, Santoro, M L, Ota, V K, Noto, C, Abdellaoui, A, Beekman, A T F, Dolan, C V, Hottenga, J J, Jansen, R, Mbarek, H, Milaneschi, Y, Nivard, M G, Posthuma, D, Boomsma, D I, de Geus, E J C, Curtis, C, Newhouse, S J, Patel, H, Hall, L S, O`Reilly, P F, Belangero, S I, Bressan, R A, Breen, G & Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium 2018, ' Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder ', Communications biology, vol. 1, 163, pp. 1-10 . https://doi.org/10.1038/s42003-018-0155-y
de Jong, S, Diniz, M J A, Saloma, A, Gadelha, A, Santoro, M L, Ota, V K, Noto, C, Curtis, C, Newhouse, S J, Patel, H, Hall, L S, O Reilly, P F, Belangero, S I, Bressan, R A, Breen, G & Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium (Per Qvist and Preben Bo Mortensen, members of-) 2018, ' Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder ', Communications Biology, vol. 1, 163 . https://doi.org/10.1038/s42003-018-0155-y
Communications biology, vol. 1, pp. 163
Communications biology, 1:163. Nature Publishing Group
COMMUNICATIONS BIOLOGY
Communications biology, 1:163, 1-10. Nature Research
2018, ' Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder ', Communications biology, vol. 1, pp. 163 . https://doi.org/10.1038/s42003-018-0155-y
Communications Biology, 1(1):163. Springer Nature
Communications biology 1(1), 163 (2018). doi:10.1038/s42003-018-0155-y
Communications Biology, Vol 1, Iss 1, Pp 1-10 (2018)
Communications biology, vol 1, iss 1
bioRxiv
de Jong, S, Diniz, M J A, Saloma, A, Gadelha, A, Santoro, M L, Ota, V K, Noto, C, Abdellaoui, A, Beekman, A T F, Dolan, C V, Hottenga, J J, Jansen, R, Mbarek, H, Milaneschi, Y, Nivard, M G, Posthuma, D, Boomsma, D I, de Geus, E J C, Curtis, C, Newhouse, S J, Patel, H, Hall, L S, O`Reilly, P F, Belangero, S I, Bressan, R A, Breen, G & Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium 2018, ' Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder ', Communications biology, vol. 1, 163, pp. 1-10 . https://doi.org/10.1038/s42003-018-0155-y
de Jong, S, Diniz, M J A, Saloma, A, Gadelha, A, Santoro, M L, Ota, V K, Noto, C, Curtis, C, Newhouse, S J, Patel, H, Hall, L S, O Reilly, P F, Belangero, S I, Bressan, R A, Breen, G & Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium (Per Qvist and Preben Bo Mortensen, members of-) 2018, ' Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder ', Communications Biology, vol. 1, 163 . https://doi.org/10.1038/s42003-018-0155-y
Communications biology, vol. 1, pp. 163
Communications biology, 1:163. Nature Publishing Group
COMMUNICATIONS BIOLOGY
Communications biology, 1:163, 1-10. Nature Research
2018, ' Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder ', Communications biology, vol. 1, pp. 163 . https://doi.org/10.1038/s42003-018-0155-y
Communications Biology, 1(1):163. Springer Nature
Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8e31d0d65994c29da2992d71dc1c70
https://hdl.handle.net/1956/19697
https://hdl.handle.net/1956/19697
Autor:
Layla Kassem, Stefan Herms, Jens Treutlein, Manuel Mattheisen, Josef Frank, René Breuer, Francis J. McMahon, George Karypis, Thomas W. Mühleisen, Marcella Rietschel, Jana Strohmaier, Bertram Krumm, Markus M. Nöthen, Sven Cichon, Franziska Degenhardt, Thomas G. Schulze
Disentangling the etiology of common, complex diseases is a major challenge in genetic research. For bipolar disorder (BD), several genome-wide association studies (GWAS) have been performed. Similar to other complex disorders, major breakthroughs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377625a6a56dc2889c57aa850d16a360
https://doi.org/10.1101/116624
https://doi.org/10.1101/116624
Autor:
Jana Strohmaier, Thomas G. Schulze, Sandra Meier, Stefan Wüst, René Breuer, Manuel Mattheisen, Marcella Rietschel, Markus M. Nöthen, Thomas W. Mühleisen, Sven Cichon, Franziska Degenhardt
Publikováno v:
The International Journal of Neuropsychopharmacology
Linkage and fine mapping studies have established that the neuregulin 3 gene (NRG3) is a susceptibility locus for schizophrenia. Association studies of this disorder have implicated NRG3 variants in both psychotic symptoms and attention performance.
Autor:
René Breuer, Markus M. Nöthen, Mike A. Nalls, Jo Steele, Nirmala Akula, Andrew B. Singleton, Marcella Rietschel, Sven Cichon, Thomas G. Schulze, Francis J. McMahon, Franziska Degenhardt
Publikováno v:
The World Journal of Biological Psychiatry. 15:200-208
Genome-wide association studies (GWAS) in complex phenotypes, including psychiatric disorders, have yielded many replicated findings, yet individual markers account for only a small fraction of the inherited differences in risk. We tested the perform
Autor:
Ingrid Melle, Vidar M. Steen, Thomas G. Schulze, Markus M. Nöthen, Srdjan Djurovic, Lutz Priebe, Thomas Hansen, Helle Lybæk, Marcella Rietschel, Ole A. Andreassen, Sven Cichon, Thomas Werge, René Breuer, Bjarte Håvik, Beth Stevens, Clive R. Bramham, Thomas W. Mühleisen, Franziska Degenhardt, Wolfgang Maier, Stephanie Le Hellard, Manuel Mattheisen, Ingrid Agartz
Publikováno v:
Biological Psychiatry. 70:35-42
Background Patients with schizophrenia often suffer from cognitive dysfunction, including impaired learning and memory. We recently demonstrated that long-term potentiation in rat hippocampus, a mechanistic model of learning and memory, is linked to
Autor:
Stefan Herms, Dan Rujescu, Marcella Rietschel, Markus M. Nöthen, Heinrich Sauer, Michael Ludwig, Susanne Moebus, Igor Nenadic, F. Buket Basmanav, Wolfgang Maier, Thomas W. Mühleisen, Andreas J. Forstner, Rainald Mössner, René Breuer, Sven Cichon, Lutz Priebe, Manuel Mattheisen
Publikováno v:
Schizophrenia Research. 127:35-40
Large rare deletions in NRXN1 increase the risk for schizophrenia. The aim of the present study was to determine whether small rare sequence changes in exons and splice sites contribute to the development of schizophrenia in a high-penetrance manner.