Zobrazeno 1 - 10
of 27
pro vyhledávání: '"René Boucher"'
Autor:
Paul J. Bédard, René Boucher, Céline Gagnon, Rudolf Markstein, Thérèse Di Paolo, Baltazar Gomez-Mancilla
Publikováno v:
Movement Disorders. 8:144-150
A group of four cynomolgus monkeys previously rendered parkinsonian by the toxin 1-methyl-4-phenyl, 1, 2, 3, 6-tetrahydropyridine (MPTP) were observed in locomotion cages equipped with photocells during four periods of 7 days during which they receiv
Publikováno v:
Movement Disorders. 7:137-141
Based on the hypothesis that low-threshold calcium conductance in the thalamus might be involved in the pathophysiology of parkinsonian tremor, ethosuximide was given chronically to a monkey previously treated with MPTP and displaying exceptionally a
Publikováno v:
Movement Disorders. 7:43-47
The antitremor effect of the D2 agonist LY 171555 and of the D1 agonist CY 208-243 alone and in combination was tested in a monkey previously rendered parkinsonian by MPTP and displaying exceptionally a rest termor in the limbs. The D2 agonist suppre
Publikováno v:
Clinical Neuropharmacology. 14:359-366
The purported alpha 2-adrenergic agonist clonidine was found to inhibit rest tremor at doses of 0.023-0.1 mg/kg in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkey model of parkinsonism. The effect was dose dependent, but sedation and reduced
Publikováno v:
Brain Research. 379:286-293
5Macaca fascicularis monkeys developed a severe parkinsonian syndrome in the days following intravenous administration of the toxin MPTP. One monkey remained untreated while two groups of two animals were treated daily for 5 months with supramaximal
Publikováno v:
Experimental Neurology. 82:172-182
In previous work, we demonstrated in animals and humans an antidopaminergic effect of estradiol at the level of the striatum. In the present study, we tested the effect of a large dose of estradiol (0.5 mg s.c.) administered either acutely or during
Publikováno v:
Neuroscience Letters. 17:89-94
In rats bearing a unilateral lesion of the entopeduncular nucleus, female sexual hormones administered daily for fifteen days can decrease the rate o circling and the motility counts recorded after an injection of apomorphine 0.5 mg/kg, s.c. This sug
Autor:
Y. Quere, René Boucher
Publikováno v:
Journal of Nuclear Materials. 100:132-136
Publikováno v:
Neuroscience Letters. 58:327-331
In 4 ovariectomized monkeys bearing a dopamine-sensitive lingual dyskinesia due to a previous mid-brain lesion, 30 ng of 17 beta-estradiol injected subcutaneously, caused a 4-fold increase in the dyskinesia in the hour following the injection. In a s