Zobrazeno 1 - 10
of 511
pro vyhledávání: '"René Bernards"'
Autor:
Antonio Mulero‐Sánchez, Christel F. A. Ramirez, Aimée duChatinier, Hui Wang, Sofie J. I. Koomen, Ji‐Ying Song, Marnix H. P. deGroot, Cor Lieftink, Astrid Bosma, Artur Burylo, Olaf vanTellingen, Roderick L. Beijersbergen, Cun Wang, Leila Akkari, René Bernards, Sara Mainardi
Publikováno v:
Molecular Oncology, Vol 17, Iss 6, Pp 964-980 (2023)
Liver cancer is the fourth most common cause of cancer‐related death worldwide, with hepatocellular carcinoma (HCC) being the main primary malignancy affecting the liver. Unfortunately, there are still limited therapeutic options for HCC, and even
Externí odkaz:
https://doaj.org/article/127c0b27e58a4e90916c39f950995ed1
Autor:
Xuhui Ma, Shanshan Wu, Botai Li, Qianqian Zhang, Jianming Zhang, Wenming Liu, Hexin Yan, René Bernards, Wenxin Qin, Cun Wang
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/de8cbb4b99c84f618803a3cd57b2add1
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 5, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/b16be8896cd04cf281a9a8757a88fb71
Autor:
Barbara Steurer, Roel C. Janssens, Marit E. Geijer, Fernando Aprile-Garcia, Bart Geverts, Arjan F. Theil, Barbara Hummel, Martin E. van Royen, Bastiaan Evers, René Bernards, Adriaan B. Houtsmuller, Ritwick Sawarkar, Jurgen Marteijn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
DNA damage inhibits elongating RNA polymerase II, but also initiates genome-wide transcriptional responses. Here the authors reveal that particularly promoter-bound Pol II is degraded upon DNA damage in a GSK3 signaling-mediated response.
Externí odkaz:
https://doaj.org/article/8ae0ddc4ec8841d3a8a8b7435095a252
Publikováno v:
Molecular Oncology, Vol 17, Iss 6, Pp 919-920 (2023)
The formation of organisations and societies within all areas of scientific research facilitates the bringing together of researchers in a given field and serves to aid communication, collaboration, progress of science and career development. Even gr
Externí odkaz:
https://doaj.org/article/7dd4388185df47cd97eb3656b48eb6a5
Autor:
Yangyang Zhou, Siying Wang, Wei Wu, Jing Ling, Haoyu Li, Qi Jia, Jiaojiao Zheng, Xingling Zheng, Ruobing Yu, Qiangxin Wu, Yaoping Shi, Cor Lieftink, Roderick L. Beijersbergen, Shengxian Yuan, René Bernards, Haojie Jin, Wenxin Qin
Publikováno v:
EBioMedicine, Vol 87, Iss , Pp 104397- (2023)
Summary: Background: Identification of tumor dependencies is important for developing therapeutic strategies for liver cancer. Methods: A genome-wide CRISPR screen was performed for finding critical vulnerabilities in liver cancer cells. Compounds sc
Externí odkaz:
https://doaj.org/article/1193efc1668040f5849c69f967094fdf
Autor:
René Bernards
Publikováno v:
Molecular Oncology, Vol 17, Iss 3, Pp 382-383 (2023)
The advent of a new generation of targeted cancer drugs requires a radically different design of early clinical trials. Here, René Bernards discusses why new clinical trial designs are needed and what is being done to achieve this. Such innovative t
Externí odkaz:
https://doaj.org/article/d32eea358caa4ad9a1b94f0378c15e2f
Autor:
Yuchen Guo, Jun Wang, Bente Benedict, Chen Yang, Frank van Gemert, Xuhui Ma, Dongmei Gao, Hui Wang, Shu Zhang, Cor Lieftink, Roderick L. Beijersbergen, Hein te Riele, Xiaohang Qiao, Qiang Gao, Chong Sun, Wenxin Qin, René Bernards, Cun Wang
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
Abstract Background Liver cancer is one of the most commonly diagnosed cancers and the fourth leading cause of cancer-related death worldwide. Broad-spectrum kinase inhibitors like sorafenib and lenvatinib provide only modest survival benefit to pati
Externí odkaz:
https://doaj.org/article/d3b40c6ab0ea4445955311ad736bc6e4
Autor:
Matheus Henrique Dias, René Bernards
Publikováno v:
Molecular Oncology, Vol 15, Iss 8, Pp 1975-1985 (2021)
In psychotherapy, paradoxical interventions are characterized by a deliberate reinforcement of the pathological behavior to improve the clinical condition. Such a counter‐intuitive approach can be considered when more conventional interventions fai
Externí odkaz:
https://doaj.org/article/1f5c0b430ad144fea1bcb5e5f5ab5ff2
Autor:
Evert Bosdriesz, João M. Fernandes Neto, Anja Sieber, René Bernards, Nils Blüthgen, Lodewyk F.A. Wessels
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104760- (2022)
Summary: Targeted inhibition of aberrant signaling is an important treatment strategy in cancer, but responses are often short-lived. Multi-drug combinations have the potential to mitigate this, but to avoid toxicity such combinations must be selecti
Externí odkaz:
https://doaj.org/article/79751c290deb41b19b7a9a972294987f