Fridamycin A, a Microbial Natural Product, Stimulates Glucose Uptake without Inducing Adipogenesis

Autor: Sun-Young Yoon, Seoung Rak Lee, Ji Young Hwang, René Benndorf, Christine Beemelmanns, Sang J. Chung, Ki Hyun Kim

Publikováno v: Nutrients, Vol 11, Iss 4, p 765 (2019)

Type 2 diabetes is a complex, heterogeneous, and polygenic disease. Currently, available drugs for treating type 2 diabetes predominantly include sulfonylureas, α-glucosidase inhibitors, and biguanides. However, long-term treatment with these therap

Externí odkaz: https://doaj.org/article/50ce8038a9fe48d4922e62cbfad4bd33

Natural Products from Actinobacteria Associated with Fungus-Growing Termites

Autor: René Benndorf, Huijuan Guo, Elisabeth Sommerwerk, Christiane Weigel, Maria Garcia-Altares, Karin Martin, Haofu Hu, Michelle Küfner, Z. Wilhelm de Beer, Michael Poulsen, Christine Beemelmanns

Publikováno v: Antibiotics, Vol 7, Iss 3, p 83 (2018)

The chemical analysis of insect-associated Actinobacteria has attracted the interest of natural product chemists in the past years as bacterial-produced metabolites are sought to be crucial for sustaining and protecting the insect host. The objective

Externí odkaz: https://doaj.org/article/8dbbb96fca1a41a7b663b112941a4ae7

Gene Cluster Activation in a Bacterial Symbiont Leads to Halogenated Angucyclic Maduralactomycins and Spirocyclic Actinospirols

Autor: Christoph Steinbeck, Helmar Görls, Martin Baunach, Z. Wilhelm de Beer, Huijuan Guo, Lars Regestein, Jan W Schwitalla, Christine Beemelmanns, René Benndorf

Publikováno v: Organic Letters. 22:2634-2638

Growth from spores activated a biosynthetic gene cluster in Actinomadura sp. RB29, resulting in the identification of two novel groups of halogenated polyketide natural products, named maduralactomycins and actinospirols. The unique tetracyclic and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc04e9b353f8e171c0cda2c19eec21b
https://doi.org/10.1021/acs.orglett.0c00601

Comparative Genomic and Metabolic Analysis of Streptomyces sp. RB110 Morphotypes Illuminates Genomic Rearrangements and Formation of a New 46-Membered Antimicrobial Macrolide

Autor: Sirinthra Thiengmag, Soohyun Um, Christine Beemelmanns, René Benndorf, Daniel F.O. Braga, Maja Rischer, Huijuan Guo, Z. Wilhelm de Beer, Gerald Lackner, Robert Murphy, Michael Poulsen

Publikováno v: Um, S, Guo, H, Thiengmag, S, Benndorf, R, Murphy, R, Rischer, M, Braga, D, Poulsen, M, de Beer, Z W, Lackner, G & Beemelmanns, C 2021, ' Comparative Genomic and Metabolic Analysis of Streptomyces sp. RB110 Morphotypes Illuminates Genomic Rearrangements and Formation of a New 46-Membered Antimicrobial Macrolide ', ACS chemical biology, vol. 16, no. 8, pp. 1482-1492 . https://doi.org/10.1021/acschembio.1c00357

Morphotype switches frequently occur in Actinobacteria and are often associated with disparate natural product production. Here, we report on differences in the secondary metabolomes of two morphotypes of a Streptomyces species, including the discove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39d59d4b655a35135168f3a5d0e68d4
https://curis.ku.dk/ws/files/312758959/RB110_submission_24_6_final_SHU_1_.pdf

Streptomyces smaragdinus sp. nov., isolated from the gut of the fungus growing-termite Macrotermes natalensis

Autor: Jan W Schwitalla, Christine Beemelmanns, Karin Martin, John Vollmers, René Benndorf, Michael Poulsen, Anne-Kristin Kaster, Z. Wilhelm de Beer

Publikováno v: International journal of systematic and evolutionary microbiology, 70 (11), 5806–5811
Schwitalla, J W, Benndorf, R, Martin, K, Vollmers, J, Kaster, A-K, Wilhelm de Beer, Z, Poulsen, M & Beemelmanns, C 2020, ' Streptomyces smaragdinus sp. nov., isolated from the gut of the fungus growing-termite Macrotermes natalensis ', International Journal of Systematic and Evolutionary Microbiology, vol. 70, no. 11, pp. 5806-5811 . https://doi.org/10.1099/ijsem.0.004478
International Journal of Systematic and Evolutionary Microbiology

The taxonomic position of a novel aerobic, Gram-positive actinobacteria, designated strain RB5T, was determined using a polyphasic approach. The strain, isolated from the gut of the fungus-farming termite Macrotermes natalensis, showed morphological,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada78ac1fe0590f0c806745a2a868e2e
https://publikationen.bibliothek.kit.edu/1000124550