β-Hydroxy-β-methylbutyrate (HMB) supplementation and functional outcomes in multi-trauma patients: a study protocol for a pilot randomised clinical trial (BOOST trial)

Autor: Kym Wittholz, Kate Fetterplace, Yasmine Ali Abdelhamid, Jeffrey J. Presneill, Lisa Beach, Benjamin Thomson, David Read, René Koopman, Adam M. Deane

Publikováno v: Pilot and Feasibility Studies, Vol 8, Iss 1, Pp 1-11 (2022)

Abstract Background There are no therapies proven to diminish the muscle wasting that occurs in patients after major trauma who are admitted to the intensive care unit (ICU). β-Hydroxy-β-methylbutyrate (HMB) is a nutrition intervention that may att

Externí odkaz: https://doaj.org/article/6865cb8b61a841009227a0a3467a5ee7

Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice

Autor: Daniel J. Ham, Anastasia Gardner, Tahnee L. Kennedy, Jennifer Trieu, Timur Naim, Annabel Chee, Francesca M. Alves, Marissa K. Caldow, Gordon S. Lynch, René Koopman

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)

Abstract Duchenne muscular dystrophy (DMD) is an X-linked genetic disease characterized by progressive muscle wasting and weakness and premature death. Glucocorticoids (e.g. prednisolone) remain the only drugs with a favorable impact on DMD patients,

Externí odkaz: https://doaj.org/article/6271200ce1974e419391ebe4bea3de4c

Albumin and C-reactive protein relate to functional and body composition parameters in patients admitted to geriatric rehabilitation after acute hospitalization

Autor: Jeanine M. Van Ancum, Camilla S. L. Tuttle, René Koopman, Mirjam Pijnappels, Carel G. M. Meskers, Sanjoy K. Paul, Wen Kwang Lim, Esmee M. Reijnierse, Gordon S. Lynch, Andrea B. Maier

Publikováno v: European Geriatric Medicine, 13(3), 623-632. Elsevier Masson
van Ancum, J M, Tuttle, C S L, Koopman, R, Pijnappels, M, Meskers, C G M, Paul, S K, Lim, W K, Reijnierse, E M, Lynch, G S & Maier, A B 2022, ' Albumin and C-reactive protein relate to functional and body composition parameters in patients admitted to geriatric rehabilitation after acute hospitalization : findings from the RESORT cohort ', European Geriatric Medicine, vol. 13, no. 3, pp. 623-632 . https://doi.org/10.1007/s41999-022-00625-5

Purpose Albumin and C-reactive protein (CRP) are non-specific markers of inflammation, which could affect muscle tissue during acute hospitalization. We investigated the association between albumin and CRP during acute hospitalization with functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129e2a74abc0a4aef09edae4edd23296
http://www.scopus.com/inward/record.url?scp=85125470137&partnerID=8YFLogxK

Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury.

Autor: Kristy Swiderski, Marissa K Caldow, Timur Naim, Jennifer Trieu, Annabel Chee, René Koopman, Gordon S Lynch

Publikováno v: PLoS ONE, Vol 14, Iss 2, p e0212880 (2019)

Muscles of older animals are more susceptible to injury and regenerate poorly, in part due to a persistent inflammatory response. The janus kinase (Jak)/signal transducer and activator of transcription (Stat) pathway mediates inflammatory signaling a

Externí odkaz: https://doaj.org/article/f6fe9446f9d741ab87341f0df429af07

Functional electrical stimulation in-bed cycle ergometry in mechanically ventilated patients: a multicentre randomised controlled trial

Autor: Elizabeth Colantuoni, Ramona O. Hopkins, Zudin Puthucheary, Linda Denehy, Dale M. Needham, Joleen W. Rose, Susan C Berney, Selina M Parry, Ian Gordon, Amy M. Pastva, René Koopman

Publikováno v: Thorax. 76:656-663

PurposeTo investigate the effect of functional electrical stimulation-assisted cycle ergometry (FES-cycling) on muscle strength, cognitive impairment and related outcomes.MethodsMechanically ventilated patients aged ≥18 years with sepsis or systemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa446277e501a4595503e50b27fa93ce
https://doi.org/10.1136/thoraxjnl-2020-215093