Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Renáta Minorics"'
Autor:
Mária Gáborová, Máté Vágvölgyi, Bizhar Ahmed Tayeb, Renáta Minorics, István Zupkó, Ondřej Jurček, Szabolcs Béni, Renata Kubínová, György Tibor Balogh, Attila Hunyadi
Publikováno v:
ACS Omega, Vol 9, Iss 16, Pp 18495-18504 (2024)
Externí odkaz:
https://doaj.org/article/7fbece91a8724e5fae69ba49cb526264
Autor:
Eszter Boglárka Lőrincz, Gergely Tóth, Júlia Spolárics, Mihály Herczeg, Jan Hodek, István Zupkó, Renáta Minorics, Dorottya Ádám, Attila Oláh, Christos C. Zouboulis, Jan Weber, Lajos Nagy, Eszter Ostorházi, Ildikó Bácskay, Anikó Borbás, Pál Herczegh, Ilona Bereczki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract (−)-Cannabidiol (CBD) and (−)-cannabigerol (CBG) are two major non-psychotropic phytocannabinoids that have many beneficial biological properties. However, due to their low water solubility and prominent first-pass metabolism, their oral
Externí odkaz:
https://doaj.org/article/5a9a372dc9b844a19bbb1a3fff919b53
Autor:
Etelka Ferenczi, Péter Keglevich, Bizhar Ahmed Tayeb, Renáta Minorics, Dávid Papp, Gitta Schlosser, István Zupkó, László Hazai, Antal Csámpai
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7428 (2024)
In the frame of our diversity-oriented research on multitarget small molecule anticancer agents, utilizing convergent synthetic sequences terminated by Sonogashira coupling reactions, a preliminary selection of representative alkyne-tethered vindolin
Externí odkaz:
https://doaj.org/article/82b2a08f9cea460fbcb6554b0b426536
Autor:
Isaac Kinyua Njangiru, Noémi Bózsity-Faragó, Vivien Erzsébet Resch, Gábor Paragi, Éva Frank, György T. Balogh, István Zupkó, Renáta Minorics
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 622 (2024)
The clinical application of 2-methoxyestradiol (2ME) in cancer therapy has been limited by its low solubility and rapid metabolism. Derivatives of 2ME have been synthesised to enhance bioavailability and decrease hepatic metabolism. Compound 4a, an a
Externí odkaz:
https://doaj.org/article/afb882dda7f946a8b6d7d0873b560d71
Autor:
Sara H H Ahmed, Bizhar A Tayeb, Tímea Gonda, Gábor Girst, Kornél Szőri, Róbert Berkecz, István Zupkó, Renáta Minorics, Attila Hunyadi
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0291567 (2024)
We describe herein the synthesis of eight new ester-coupled hybrid compounds from thymoquinone and protoflavone building blocks, and their bioactivity testing against multiple cancer cell lines. Among the hybrids, compound 14 showed promising activit
Externí odkaz:
https://doaj.org/article/295715552911447dbfd1cfdac0bd83c8
Autor:
Noémi Bózsity, Viktória Nagy, Johanna Szabó, Balázs Pálházi, Zoltán Kele, Vivien Resch, Gábor Paragi, István Zupkó, Renáta Minorics, Erzsébet Mernyák
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4274 (2024)
Directed structural modifications of natural products offer excellent opportunities to develop selectively acting drug candidates. Natural product hybrids represent a particular compound group. The components of hybrids constructed from different mol
Externí odkaz:
https://doaj.org/article/cdf80854a1f5439bad03d3851450f7a1
Autor:
Seyyed Ashkan Senobar Tahaei, Ágnes Kulmány, Renáta Minorics, Anita Kiss, Zoltán Szabó, Péter Germán, Gábor J. Szebeni, Nikolett Gémes, Erzsébet Mernyák, István Zupkó
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13749 (2023)
Four diastereomers of 16-azidomethyl substituted 3-O-benzyl estradiol (1–4) and their two estrone analogs (16AABE and 16BABE) were tested for their antiproliferative properties against human gynecological cancer cell lines. The estrones were select
Externí odkaz:
https://doaj.org/article/0deb97d3b5994929ac415dbecd47e1c3
Autor:
Viktória Nagy, Raji Mounir, Gábor J. Szebeni, Zsolt Szakonyi, Nikolett Gémes, Renáta Minorics, Péter Germán, István Zupkó
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10581 (2023)
The present study aimed to characterize the antiproliferative and antimetastatic properties of two recently synthesized monoterpene-aminopyrimidine hybrids (1 and 2) on A2780 ovary cancer cells. Both agents exerted a more pronounced cell growth inhib
Externí odkaz:
https://doaj.org/article/3543d74e3e7647bb811aea7228bb4dd0
Autor:
Hazhmat Ali, Péter Traj, Gábor J. Szebeni, Nikolett Gémes, Vivien Resch, Gábor Paragi, Erzsébet Mernyák, Renáta Minorics, István Zupkó
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6625 (2023)
Cervical carcinoma is one of the most frequent malignant gynecological cancers in women of reproductive age. Because of the poor tolerability of currently available chemotherapeutic agents, efforts have been focused on developing innovative molecules
Externí odkaz:
https://doaj.org/article/b75fba85d6d440e291bb454e8c72a5be
Autor:
Erzsébet Mernyák, Sándor Bartha, Lili Kóczán, Rebeka Jójárt, Vivien Resch, Gábor Paragi, Máté Vágvölgyi, Attila Hunyadi, Bella Bruszel, István Zupkó, Renáta Minorics
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1931-1937 (2021)
Microwave-assisted phospha-Michael addition reactions were carried out in the 13α-oestrone series. The exocyclic 16-methylene-17-ketones as α,β-unsaturated ketones were reacted with secondary phosphine oxides as nucleophilic partners. The addition
Externí odkaz:
https://doaj.org/article/cf583eaeec9e45a3aa656d5aef85ad16