Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ren, X Sun"'
Autor:
Peter Y.F. Zeng, Stephenie D. Prokopec, Stephen Y. Lai, Nicole Pinto, Michelle A. Chan-Seng-Yue, Roderick Clifton-Bligh, Michelle D. Williams, Christopher J. Howlett, Paul Plantinga, Matthew J. Cecchini, Alfred K. Lam, Iram Siddiqui, Jianxin Wang, Ren X. Sun, John D. Watson, Reju Korah, Tobias Carling, Nishant Agrawal, Nicole Cipriani, Douglas Ball, Barry Nelkin, Lisa M. Rooper, Justin A. Bishop, Cathie Garnis, Ken Berean, Norman G. Nicolson, Paul Weinberger, Ying C. Henderson, Christopher M. Lalansingh, Mao Tian, Takafumi N. Yamaguchi, Julie Livingstone, Adriana Salcedo, Krupal Patel, Frederick Vizeacoumar, Alessandro Datti, Liu Xi, Yuri E. Nikiforov, Robert Smallridge, John A. Copland, Laura A. Marlow, Martin D. Hyrcza, Leigh Delbridge, Stan Sidhu, Mark Sywak, Bruce Robinson, Kevin Fung, Farhad Ghasemi, Keith Kwan, S. Danielle MacNeil, Adrian Mendez, David A. Palma, Mohammed I. Khan, Mushfiq Shaikh, Kara M. Ruicci, Bret Wehrli, Eric Winquist, John Yoo, Joe S. Mymryk, James W. Rocco, David Wheeler, Steve Scherer, Thomas J. Giordano, John W. Barrett, William C. Faquin, Anthony J. Gill, Gary Clayman, Paul C. Boutros, Anthony C. Nichols
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113826- (2024)
Summary: Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroid
Externí odkaz:
https://doaj.org/article/c5a6abf2e7ba48ce977235cab50cb266
Autor:
Oliver A. Kent, Manipa Saha, Etienne Coyaud, Helen E. Burston, Napoleon Law, Keith Dadson, Sujun Chen, Estelle M. Laurent, Jonathan St-Germain, Ren X. Sun, Yoshinori Matsumoto, Justin Cowen, Aaryn Montgomery-Song, Kevin R. Brown, Charles Ishak, Jose La Rose, Daniel D. De Carvalho, Housheng Hansen He, Brian Raught, Filio Billia, Peter Kannu, Robert Rottapel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mutations in RAS-MAPK pathway genes are implicated in Noonan-spectrum, yet up to 20% of cases have unknown cause. Here, the authors identify RREB1 underlying a 6p microdeletion RASopathy-like syndrome and show that RREB1, SIN3A and KDM1A form a trans
Externí odkaz:
https://doaj.org/article/7477dd54517347169cc4551af1667746
Autor:
Constance H. Li, Stephenie D. Prokopec, Ren X. Sun, Fouad Yousif, Nathaniel Schmitz, PCAWG Tumour Subtypes and Clinical Translation, Paul C. Boutros, PCAWG Consortium
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-24 (2020)
There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.
Externí odkaz:
https://doaj.org/article/eb0e62b5b1ad4e72be0a993246cb8d67
Autor:
Carly Strelez, Sujatha Chilakala, Kimya Ghaffarian, Roy Lau, Erin Spiller, Nolan Ung, Danielle Hixon, Ah Young Yoon, Ren X. Sun, Heinz-Josef Lenz, Jonathan E. Katz, Shannon M. Mumenthaler
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102509- (2021)
Summary: Colorectal cancer (CRC) progression is a complex process that is not well understood. We describe an in vitro organ-on-chip model that emulates in vivo tissue structure and the tumor microenvironment (TME) to better understand intravasation,
Externí odkaz:
https://doaj.org/article/caf16ab096014c8ea201b27cc1beccf1
Autor:
Christine P’ng, Jeffrey Green, Lauren C. Chong, Daryl Waggott, Stephenie D. Prokopec, Mehrdad Shamsi, Francis Nguyen, Denise Y. F. Mak, Felix Lam, Marco A. Albuquerque, Ying Wu, Esther H. Jung, Maud H. W. Starmans, Michelle A. Chan-Seng-Yue, Cindy Q. Yao, Bianca Liang, Emilie Lalonde, Syed Haider, Nicole A. Simone, Dorota Sendorek, Kenneth C. Chu, Nathalie C. Moon, Natalie S. Fox, Michal R. Grzadkowski, Nicholas J. Harding, Clement Fung, Amanda R. Murdoch, Kathleen E. Houlahan, Jianxin Wang, David R. Garcia, Richard de Borja, Ren X. Sun, Xihui Lin, Gregory M. Chen, Aileen Lu, Yu-Jia Shiah, Amin Zia, Ryan Kearns, Paul C. Boutros
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-5 (2019)
Abstract Background We introduce BPG, a framework for generating publication-quality, highly-customizable plots in the R statistical environment. Results This open-source package includes multiple methods of displaying high-dimensional datasets and f
Externí odkaz:
https://doaj.org/article/4314e3a47df049aeb55750230ad05c88
Autor:
Helen E. Burston, Oliver A. Kent, Ren X. Sun, Justin Cowen, Daniel D. De Carvalho, Sujun Chen, Jonathan St-Germain, Robert Rottapel, Aaryn Montgomery-Song, Manipa Saha, Yoshinori Matsumoto, Napoleon Law, Housheng Hansen He, Kevin R. Brown, Peter Kannu, Jose La Rose, Keith Dadson, Charles A. Ishak, Filio Billia, Etienne Coyaud, Brian Raught, Estelle M.N. Laurent
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, 2020, Nature Communications, 11 (4673), ⟨10.1038/s41467-020-18483-9⟩
Nature Communications
Nature Communications, 2020, Nature Communications, 11 (4673), ⟨10.1038/s41467-020-18483-9⟩
RAS-MAPK signaling mediates processes critical to normal development including cell proliferation, survival, and differentiation. Germline mutation of RAS-MAPK genes lead to the Noonan-spectrum of syndromes. Here, we present a patient affected by a 6
Autor:
Erin Spiller, Natasha Hashemi, Jasmine Foo, Roy Lau, Nolan Ung, Jordan Gasho, Ren X. Sun, Sarah Choung, Seung Il Kim, Emma J. Fong, Shannon M. Mumenthaler
Publikováno v:
Slas Discovery
3D cell culture models have been developed to better mimic the physiological environments that exist in human diseases. As such, these models are advantageous over traditional 2D cultures for screening drug compounds. However, the practicalities of t
Autor:
Grzegorz Zapotoczny, Katherin Patsch, Ren X. Sun, Mayada Aljehani, Jerry S.H. Lee, Charles E. McKenna, Chen Yu, David B. Agus, Yuanye Sun, Nolan Ung, Bethany Haliday, Harish Sura, Boris A. Kashemirov, Chao Liu, Daniel Ruderman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Small molecules that target the androgen receptor (AR) are the mainstay of therapy for lethal castration-resistant prostate cancer (CRPC), yet existing drugs lose their efficacy during continued treatment. This evolution of resistance is due to heter
Autor:
Anne-Marie Mes-Masson, Molly L. Udaskin, Ren X. Sun, Euihye Jung, Kevin R. Brown, Laudine Communal, Jose La Rose, Ronny Drapkin, Joshua K. Lowitz, Kyle E. Francis, Helen E. Burston, Oliver A. Kent, Robert Rottapel
Publikováno v:
J Clin Invest
Ovarian cancer (OC) is the most deadly gynecological malignancy, with unmet clinical need for new therapeutic approaches. The relaxin peptide is a pleiotropic hormone with reproductive functions in the ovary. Relaxin induces cell growth in several ty
Autor:
Nicole Pinto, Farhad Ghasemi, Eric Winquist, Kara M. Ruicci, John Yoo, Alessandro Datti, Morgan Black, M. Imran Khan, Anthony C. Nichols, Jalna Meens, Myung Woul Han, William Stecho, Ren X. Sun, Christopher J. Howlett, Danielle MacNeil, David A. Palma, Mushfiq Hassan Shaikh, Laurie Ailles, Kevin Fung, Paul C. Boutros, John W. Barrett, Joe S. Mymryk
Spleen tyrosine kinase (SYK) is a promoter of cell survival in a variety of cell types, including normal and cancerous epithelial cells. We hypothesized that SYK would an important therapeutic target to inhibit for the treatment of HNSCC.SYK protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16486cc40a15a42498dd351fc429691
http://hdl.handle.net/11391/1469228
http://hdl.handle.net/11391/1469228