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The new direction of drug development: Degradation of undruggable targets through targeting chimera technology.

Autor: Liang, Xuewu, Ren, Hairu, Han, Fengyang, Liang, Renwen, Zhao, Jiayan, Liu, Hong

Publikováno v: Medicinal Research Reviews; Mar2024, Vol. 44 Issue 2, p632-685, 54p

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Development of Potent MALT1 Inhibitors Featuring a Novel "2-Thioxo-2,3-dihydrothiazolo[4,5- d ]pyrimidin-7(6 H )-one" Scaffold for the Treatment of B Cell Lymphoma.

Autor: Liang X; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Yu H; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200043, China.; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China., Liang R; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Feng Z; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200043, China., Saidahmatov A; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Sun C; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200043, China.; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China., Ren H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China., Wei X; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhao J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China., Yang C; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200043, China.; Shanghai Key Laboratory of Cell Engineering, Shanghai 200433, China., Liu H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Feb 22; Vol. 67 (4), pp. 2884-2906. Date of Electronic Publication: 2024 Feb 13.