mTORC1 Inhibitor Rapamycin Inhibits Growth of Cerebral Cavernous Malformation in Adult Mice.

Autor: Lun Li, Ren, Aileen A., Siqi Gao, Su, Yourong S., Jisheng Yang, Bockman, Jenna, Mericko-Ishizuka, Patricia, Griffin, Joanna, Shenkar, Robert, Alcazar, Roberto, Moore, Thomas, Lightle, Rhonda, DeBiasse, Dorothy, Awad, Issam A., Marchuk, Douglas A., Kahn, Mark L., Burkhardt, Jan-Karl

Publikováno v: Stroke (00392499); Nov2023, Vol. 54 Issue 11, p2906-2917, 12p

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PIK3CAand CCM mutations fuel cavernomas through a cancer-like mechanism

Autor: Ren, Aileen A., Snellings, Daniel A., Su, Yourong S., Hong, Courtney C., Castro, Marco, Tang, Alan T., Detter, Matthew R., Hobson, Nicholas, Girard, Romuald, Romanos, Sharbel, Lightle, Rhonda, Moore, Thomas, Shenkar, Robert, Benavides, Christian, Beaman, M. Makenzie, Müller-Fielitz, Helge, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Sung, Derek C., Lawton, Michael T., Ruppert, J. Michael, Schwaninger, Markus, Körbelin, Jakob, Potente, Michael, Awad, Issam A., Marchuk, Douglas A., Kahn, Mark L.

Publikováno v: Nature; June 2021, Vol. 594 Issue: 7862 p271-276, 6p

Sinusoidal and lymphatic vessel growth is controlled by reciprocal VEGF-C-CDH5 inhibition.

Autor: Sung DC; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Chen M; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Dominguez MH; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Mahadevan A; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Chen X; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Yang J; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Gao S; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Ren AA; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Tang AT; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Mericko P; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Patton R; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Lee M; University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, Pennsylvania., Jannaway M; Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida., Nottebaum A; Max Planck Institute for Molecular Biomedicine, Münster, Germany., Vestweber D; Max Planck Institute for Molecular Biomedicine, Münster, Germany., Scallan JP; Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida., Kahn ML; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2022 Nov; Vol. 1 (11), pp. 1006-1021. Date of Electronic Publication: 2022 Nov 11.