Establishing a systematic framework to characterise in vitro methods for human hepatic metabolic clearance.

Autor: Gouliarmou V; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy., Lostia AM; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy., Coecke S; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy. Electronic address: sandra.coecke@ec.europa.eu., Bernasconi C; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy., Bessems J; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy., Dorne JL; European Food Safety Authority, Via Carlo Magno, 1A, 43126 Parma, PR, Italy., Ferguson S; US National Toxicology Program, National Institute of Environmental Health Sciences, Durham, NC 27709, USA., Testai E; Istituto Superiore di Sanità, Environment & Health Dept., Viale Regina Elena 299, 00161 Rome, Italy., Remy UG; Institute for Clinical Pharmacology and Toxicology, Charité, Universitätsmedizin Berlin, Charitéplatz 1, D-110117 Berlin, Germany., Brian Houston J; Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK., Monshouwer M; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Nong A; Computational Toxicology Laboratory, Exposure and Biomonitoring Division, Health Canada - Environmental Health Science and Research Bureau, 50 Colombine Dwy, Environmental Health Centre, Tunney's Pasture AL:0800C, Ottawa, ON K1A 0K9, Canada., Pelkonen O; Research Unit of Biomedicine/Pharmacology and Toxicology, Faculty of Medicine, Aapistie 5 B, FIN-90014, University of Oulu, Finland., Morath S; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy., Wetmore BA; U.S. EPA, Office of Research and Development, National Exposure Research Laboratory, 109 T.W. Alexander Drive, MD E243-04, Research Triangle Park, NC 27711, USA., Worth A; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy., Zanelli U; Discovery DMPK, Merck KGaA Darmstadt, Germany., Zorzoli MC; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy., Whelan M; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy.

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2018 Dec; Vol. 53, pp. 233-244. Date of Electronic Publication: 2018 Aug 09.