Establishing a systematic framework to characterise in vitro methods for human hepatic metabolic clearance.

Autor: Gouliarmou V; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy., Lostia AM; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy., Coecke S; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy. Electronic address: sandra.coecke@ec.europa.eu., Bernasconi C; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy., Bessems J; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy., Dorne JL; European Food Safety Authority, Via Carlo Magno, 1A, 43126 Parma, PR, Italy., Ferguson S; US National Toxicology Program, National Institute of Environmental Health Sciences, Durham, NC 27709, USA., Testai E; Istituto Superiore di Sanità, Environment & Health Dept., Viale Regina Elena 299, 00161 Rome, Italy., Remy UG; Institute for Clinical Pharmacology and Toxicology, Charité, Universitätsmedizin Berlin, Charitéplatz 1, D-110117 Berlin, Germany., Brian Houston J; Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK., Monshouwer M; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Nong A; Computational Toxicology Laboratory, Exposure and Biomonitoring Division, Health Canada - Environmental Health Science and Research Bureau, 50 Colombine Dwy, Environmental Health Centre, Tunney's Pasture AL:0800C, Ottawa, ON K1A 0K9, Canada., Pelkonen O; Research Unit of Biomedicine/Pharmacology and Toxicology, Faculty of Medicine, Aapistie 5 B, FIN-90014, University of Oulu, Finland., Morath S; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy., Wetmore BA; U.S. EPA, Office of Research and Development, National Exposure Research Laboratory, 109 T.W. Alexander Drive, MD E243-04, Research Triangle Park, NC 27711, USA., Worth A; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy., Zanelli U; Discovery DMPK, Merck KGaA Darmstadt, Germany., Zorzoli MC; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy., Whelan M; European Commission, Joint Research Centre (JRC), Via Enrico Fermi 2749, 21027 Ispra, VA, Italy.

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2018 Dec; Vol. 53, pp. 233-244. Date of Electronic Publication: 2018 Aug 09.

Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on testing and interpretation of comparative in vitro metabolism studies.

Autor: Hernandez‐Jerez, Antonio F (AUTHOR), Adriaanse, Paulien (AUTHOR), Aldrich, Annette (AUTHOR), Berny, Philippe (AUTHOR), Coja, Tamara (AUTHOR), Duquesne, Sabine (AUTHOR), Focks, Andreas (AUTHOR), Marinovich, Marina (AUTHOR), Millet, Maurice (AUTHOR), Pelkonen, Olavi (AUTHOR), Pieper, Silvia (AUTHOR), Tiktak, Aaldrik (AUTHOR), Topping, Christopher J (AUTHOR), Widenfalk, Anneli (AUTHOR), Wilks, Martin (AUTHOR), Wolterink, Gerrit (AUTHOR), Gundert‐Remy, Ursula (AUTHOR), Louisse, Jochem (AUTHOR), Rudaz, Serge (AUTHOR), Testai, Emanuela (AUTHOR)

Publikováno v: EFSA Journal. Dec2021, Vol. 19 Issue 12, p1-61. 61p.