Zobrazeno 1 - 10
of 406
pro vyhledávání: '"Remo, Guerrini"'
Autor:
Gaetano Marverti, Maria Gaetana Moschella, Alice Belardo, Michele Lamesta, Giada Mercanile, Lorenzo Tagliazucchi, Daniele Aiello, Alberto Venturelli, Davide Illuminati, Remo Guerrini, Lorena Losi, Glauco Ponterini, Maria Paola Costi, Domenico D’Arca
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionThymidylate synthase (TS) plays a crucial role in cellular growth, proliferation, DNA synthesis, and repair, thus gaining attention for targeted therapies in cancer. TS overexpression and the altered pharmacokinetics of anti-TS drugs are
Externí odkaz:
https://doaj.org/article/047183af72c145208a402c02d10e8d5a
Autor:
Valentina Albanese, Chiara Roccatello, Salvatore Pacifico, Remo Guerrini, Delia Preti, Silvia Gentili, Matteo Tegoni, Maurizio Remelli, Denise Bellotti, Jonathan Amico, Giancarlo Gorgoni, Emiliano Cazzola
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-25 (2024)
Abstract Background Positron emission tomography (PET) is a highly sensitive method that provides fine resolution images, useful in the field of clinical diagnostics. In this context, Zirconium-89 (89Zr)-based imaging agents have represented a great
Externí odkaz:
https://doaj.org/article/8b015e677f7b462d9caf7d52aac9d576
Autor:
Maria D’Accolti, Denise Bellotti, Emilia Dzień, Carlotta Leonetti, Silvia Leveraro, Valentina Albanese, Erika Marzola, Remo Guerrini, Elisabetta Caselli, Magdalena Rowińska-Żyrek, Maurizio Remelli
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The main limitation to the use of antimicrobial peptides (AMPs) as regular drugs, against antibiotic and antifungal resistance, mainly relates to their rapid degradation by proteolytic enzymes. The introduction of suitable structural changes
Externí odkaz:
https://doaj.org/article/f55082abd99f44b7800720b35b0b10ad
Autor:
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Remo Guerrini, Valentina Albanese, Chiara Sturaro, Simona Stragapede, Davide Malfacini, Greta Compagnin, Martina Catani, Anna Fantinati
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1592 (2023)
The enormous influence in terms of bioactivity, affinity, and selectivity represented by the replacement of (L)-2,6-dimethyl tyrosine (Dmt) instead of Phenylalanine (Phe) into Nociceptin/orphanin (N/OFQ) neuropeptide analogues has been well documente
Externí odkaz:
https://doaj.org/article/6b31797137b34faaa6a39005c793b0d6
Autor:
Luca Costantino, Stefania Ferrari, Matteo Santucci, Outi MH Salo-Ahen, Emanuele Carosati, Silvia Franchini, Angela Lauriola, Cecilia Pozzi, Matteo Trande, Gaia Gozzi, Puneet Saxena, Giuseppe Cannazza, Lorena Losi, Daniela Cardinale, Alberto Venturelli, Antonio Quotadamo, Pasquale Linciano, Lorenzo Tagliazucchi, Maria Gaetana Moschella, Remo Guerrini, Salvatore Pacifico, Rosaria Luciani, Filippo Genovese, Stefan Henrich, Silvia Alboni, Nuno Santarem, Anabela da Silva Cordeiro, Elisa Giovannetti, Godefridus J Peters, Paolo Pinton, Alessandro Rimessi, Gabriele Cruciani, Robert M Stroud, Rebecca C Wade, Stefano Mangani, Gaetano Marverti, Domenico D'Arca, Glauco Ponterini, Maria Paola Costi
Publikováno v:
eLife, Vol 11 (2022)
Drugs that target human thymidylate synthase (hTS), a dimeric enzyme, are widely used in anticancer therapy. However, treatment with classical substrate-site-directed TS inhibitors induces over-expression of this protein and development of drug resis
Externí odkaz:
https://doaj.org/article/6b5ed787a8314e518ea035b5e470ee7c
Autor:
Despina Giakomidi, Sonja Khemiri, Wadhah Mahbuba, David G. McVey, Fatin Al-Janabi, Remo Guerrini, Girolamo Calo, Shu Ye, David G. Lambert
Publikováno v:
BJA Open, Vol 4, Iss , Pp 100110- (2022)
Background: Opioid receptors are naloxone-sensitive (MOP [mu: μ], DOP [delta: δ], and KOP [kappa: κ]) and naloxone-insensitive Nociceptin/Orphanin FQ (N/OFQ) peptide receptor (NOP). Clinically, most opioid analgesics target MOP. Angiogenesis is th
Externí odkaz:
https://doaj.org/article/1dee7627c7d04f38879e5822c85bdbf7
Autor:
Chiara Sturaro, Davide Malfacini, Michela Argentieri, Francine M. Djeujo, Erika Marzola, Valentina Albanese, Chiara Ruzza, Remo Guerrini, Girolamo Calo’, Paola Molinari
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The present study investigated the in vitro pharmacology of the human kappa opioid receptor using multiple assays, including calcium mobilization in cells expressing chimeric G proteins, the dynamic mass redistribution (DMR) label-free assay, and a b
Externí odkaz:
https://doaj.org/article/25d09c7909904b40bb5b128ded4d84b3
Autor:
Ming Tatt Lee, Yu-Ting Chiu, Yu-Chun Chiu, Chia Chun Hor, Hsin-Jung Lee, Remo Guerrini, Girolamo Calo, Lih-Chu Chiou
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-15 (2020)
Abstract Background Stress-induced analgesia (SIA) is an evolutionarily conserved phenomenon during stress. Neuropeptide S (NPS), orexins, substance P, glutamate and endocannabinoids are known to be involved in stress and/or SIA, however their causal
Externí odkaz:
https://doaj.org/article/53f537b86a584716bdf814fb935a0b18
Autor:
Mark F. Bird, Barbara Gallacher-Horley, John McDonald, David G. McVey, Fatin Al-Janabi, Remo Guerrini, Girolamo Calo, Shu Ye, Jonathan P. Thompson, David G. Lambert
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
Sepsis is a dysregulated host response to infection that can cause widespread effects on other organs including cardiovascular depression, hypotension and organ failure. The receptor for Nociceptin/Orphanin FQ (N/OFQ), NOP is expressed on immune cell
Externí odkaz:
https://doaj.org/article/9c6ee19a704e489aa1cb76aea8f0b547
Autor:
Valentina Albanese, Sonia Missiroli, Mariasole Perrone, Martina Fabbri, Caterina Boncompagni, Salvatore Pacifico, Tiziano De Ventura, Antonella Ciancetta, Giulio Dondio, Franz Kricek, Paolo Pinton, Remo Guerrini, Delia Preti, Carlotta Giorgi
Publikováno v:
Journal of Medicinal Chemistry. 66:5223-5241
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a4be00c473927b0c7ea7574b68d6a09
https://doi.org/10.1021/acs.jmedchem.3c00175
https://doi.org/10.1021/acs.jmedchem.3c00175