Applications of Flavoprotein Oxidases in Organic Synthesis

Autor: Marco W. Fraaije, Remko T. Winter

Publikováno v: Current organic chemistry, 16(21), 2542-2550

Oxidases represent a distinct and interesting class of oxidative biocatalysts. A major portion of the known oxidases contain a flavin as cofactor, with glucose oxidase as best known example. While a number of oxidases are well known in the field of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d71ab64cdcd901837cc594a90accbd
https://doi.org/10.2174/138527212804004661

The Nose Knows

Autor: Remko T. Winter, Marco W. Fraaije, Hugo L. van Beek

Publikováno v: Journal of Chemical Education, 89(2), 258-261

Vanillin, the compound responsible for the well-known vanilla aroma, is almost exclusively produced via a chemical process, with only a small fraction extracted from natural sources, namely, the bean of the orchid Vanilla planifolia. Research is bein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c39a6a30eec5cdbf0114d24c87cf64
https://research.rug.nl/en/publications/1481762d-7520-4fa9-a63c-10ab61e83599

A robust and extracellular heme-containing peroxidase from Thermobifida fusca as prototype of a bacterial peroxidase superfamily

Autor: Edwin van Bloois, Daniel E. Torres Pazmino, Remko T. Winter, Marco W. Fraaije

Publikováno v: Applied Microbiology and Biotechnology
Applied Microbiology and Biotechnology, 86(5), 1419-1430. SPRINGER

DyP-type peroxidases comprise a novel superfamily of heme-containing peroxidases which is unrelated to the superfamilies of known peroxidases and of which only a few members have been characterized in some detail. Here, we report the identification a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6700f3d2777c5a648d3d33c340cfc914
http://europepmc.org/articles/PMC2854361

Multiple pathways guide oxygen diffusion into flavoenzyme active sites

Autor: Pimchai Chaiyen, Marco W. Fraaije, Willem J. H. van Berkel, Pirom Chenprakhon, J. Andrew McCammon, Riccardo Baron, Andrea Mattevi, Conor T. Riley, Federico Forneris, Andrea Alfieri, Remko T. Winter, Kittisak Thotsaporn

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 106(26), 10603-10608
Proceedings of the National Academy of Sciences of the United States of America 106 (2009) 26
Proceedings of the National Academy of Sciences of the United States of America, 106(26), 10603-10608. NATL ACAD SCIENCES

Dioxygen (O 2 ) and other gas molecules have a fundamental role in a variety of enzymatic reactions. However, it is only poorly understood which O 2 uptake mechanism enzymes employ to promote efficient catalysis and how general this is. We investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4691200f37547004333d0e3268c9d33e
https://doi.org/10.1073/pnas.0903809106

The role of double covalent flavin binding in chito-oligosaccharide oxidase from Fusarium graminearum

Autor: Dominic P. H. M. Heuts, Dick B. Janssen, Marco W. Fraaije, Remko T. Winter, Gerke E. Damsma

Publikováno v: Biochemical Journal, 413(1), 175-183. PORTLAND PRESS LTD

ChitO (chito-oligosaccharide oxidase) from Fusarium graminearum catalyses the regioselective oxidation of N-acetylated oligosaccharides. The enzyme harbours an FAD cofactor that is covalently attached to His(94) and Cys(154). The functional role of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89421012e8814d41dbf0281c6efb045c
https://doi.org/10.1042/bj20071591