Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Remiszewski Stacy W"'
Autor:
KC Anderson, Peter Atadja, C Cavazza, J Kujawa, Ellen Weisberg, L Catley, Remiszewski Stacy W, James D. Griffin, P Fuerst
Publikováno v:
Leukemia. 18:1951-1963
NVP-LAQ824 is a novel potent hydroxamic acid-derived histone deacetylase inhibitor that induces apoptosis in nanomolar concentrations in myeloid leukemia cell lines and patient samples. Here we show the activity of NVP-LAQ824 in acute myeloid leukemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a792c6e4353066895abc2ae70258e9a
https://doi.org/10.1038/sj.leu.2403519
https://doi.org/10.1038/sj.leu.2403519
Autor:
Meier Hsu, Kenneth W. Bair, Arthur W. Wu, Heather Walker, Richard William Versace, Lakshmi Yeleswarapu, Dalia Cohen, Alexander W. Wood, Paul Kwon, Nancy Trogani, Remiszewski Stacy W, Larry B Perez, Lin Gao, Nagarajan Chandramouli, Peter Atadja, Lidia Sambucetti, Peter T Lassota
Publikováno v:
Cancer Research. 64:689-695
We have synthesized a histone deacetylase inhibitor, NVP-LAQ824, a cinnamic hydroxamic acid, that inhibited in vitro enzymatic activities and transcriptionally activated the p21 promoter in reporter gene assays. NVP-LAQ824 selectively inhibited growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c23af39c1e7fa71191c24a13b72384
https://doi.org/10.1158/0008-5472.can-03-2043
https://doi.org/10.1158/0008-5472.can-03-2043
Autor:
Remiszewski Stacy W
Publikováno v:
Current Medicinal Chemistry. 10:2393-2402
The natural products trapoxin B and trichostatin A, as well as the novel marine natural product psammaplin A (PSMA) were found in a cell-based screen for compounds that induced the expression of the cyclin dependent kinase inhibitor p21(waf1). The me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a90a2c772f8634e06911a4c51bc14d5
https://doi.org/10.2174/0929867033456675
https://doi.org/10.2174/0929867033456675
Autor:
Yu-Tzu Tai, Laurence Catley, Remiszewski Stacy W, James D. Griffin, Richard Leblanc, Peter Atadja, Reshma Shringarpure, Robert L. Schlossman, Paul G. Richardson, Dharminder Chauhan, Kenneth C. Anderson, Ellen Weisberg, Nikhil C. Munshi, Nicholas Mitsiades, Teru Hideshima
Publikováno v:
Blood. 102:2615-2622
Histone deacetylase (HDAC) inhibitors are emerging as a promising new treatment strategy in hematologic malignancies. Here we show that NVP-LAQ824, a novel hydroxamic acid derivative, induces apoptosis at physiologically achievable concentrations (me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70576209d9cc12cfcfb97cc16c058ae4
https://doi.org/10.1182/blood-2003-01-0233
https://doi.org/10.1182/blood-2003-01-0233
Autor:
James W. Leahy, Regina Zibuck, Remiszewski Stacy W, Amos B. Smith, Nigel J. Liverton, Ichio Noda
Publikováno v:
ChemInform. 23
The total syntheses of (+)-latrunculin A (1) and (+)-latrunculin B (2), two architecturally novel toxins isolated from the Red Sea sponge Latrunculia magnifica (Keller), have been achieved via highly convergent and stereocontrolled routes (longest li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ab7a76a7366d1e6181e82741f38c0df
https://doi.org/10.1002/chin.199232253
https://doi.org/10.1002/chin.199232253
Autor:
Regina Zibuck, James W. Leahy, Ichio Noda, Nigel J. Liverton, Remiszewski Stacy W, Amos B. Smith
Publikováno v:
Journal of the American Chemical Society. 114:2995-3007
The total syntheses of (+)-latrunculin A (1) and (+)-latrunculin B (2), two architecturally novel toxins isolated from the Red Sea sponge Latrunculia magnifica (Keller), have been achieved via highly convergent and stereocontrolled routes (longest li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62857bdea67a6546abf130f7dd089807
https://doi.org/10.1021/ja00034a036
https://doi.org/10.1021/ja00034a036
Autor:
Paul Kirschmeier, Thomas F. Hendrickson, Remiszewski Stacy W, Wess A. Sisson, Doll Ronald J, Birendra N. Pramanik, Ashit K. Ganguly, David Cesarz, and Anthony Tsarbopoulos, Steve E. Webber, Eric C. Huang, Yu-Sen Wang, Joan E. Brown, Viyyoor M. Girijavallabhan, Robert A. Love, Bancha Vibulbhan, Taveras Arthur G, Robert M. Aust, Mark E. Snow, J. del Rosario, Edward L. Brown, Shella A. Fuhrman, Larry Heimark, and J. Ernest Villafranca, Charles R. Kissinger, D. M. Delisle
Publikováno v:
Biochemistry. 37(45)
Mutated, tumorigenic Ras is present in a variety of human tumors. Compounds that inhibit tumorigenic Ras function may be useful in the treatment of Ras-related tumors. The interaction of a novel GDP exchange inhibitor (SCH-54292) with the Ras-GDP pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8588dd08523ce1eb52765428eb0f1de
https://pubmed.ncbi.nlm.nih.gov/9843367
https://pubmed.ncbi.nlm.nih.gov/9843367
Akademický článek
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Akademický článek
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Autor:
Kester, Robert F., Donnell, Andrew F., Lou, Yan, Remiszewski, Stacy W., Lombardo, Louis J., Chen, Shaoqing, Le, Nam T., Lo, Jennifer, Moliterni, John A., Han, Xiaochun, Hogg, J. Heather, Liang, Weiling, Michoud, Christophe, Rupert, Kenneth C., Mischke, Steven, Le, Kang, Weisel, Martin, Janson, Cheryl A., Lukacs, Christine M., Fretland, Adrian J.
Publikováno v:
Journal of Medicinal Chemistry; Vol. 56 Issue 20, p7788-7803, 16p