Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Remigiusz A, Serwa"'
Autor:
Praveenraj Elancheliyan, Klaudia K. Maruszczak, Remigiusz Adam Serwa, Till Stephan, Ahmet Sadik Gulgec, Mayra A. Borrero-Landazabal, Sonia Ngati, Aleksandra Gosk, Stefan Jakobs, Michal Wasilewski, Agnieszka Chacinska
Publikováno v:
Cell Reports, Vol 43, Iss 12, Pp 115038- (2024)
Summary: Mitochondrial proteins are transported and sorted to the matrix or inner mitochondrial membrane by the presequence translocase TIM23. In yeast, this essential and highly conserved machinery is composed of the core subunits Tim23 and Tim17. T
Externí odkaz:
https://doaj.org/article/1e7dc652ec4847c18ec5c1a54c5dd31c
Autor:
Tomasz M. Stępkowski, Vanessa Linke, Dorota Stadnik, Maciej Zakrzewski, Anna E. Zawada, Remigiusz A. Serwa, Agnieszka Chacinska
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114803- (2024)
Summary: Under stress, protein synthesis is attenuated to preserve energy and mitigate challenges to protein homeostasis. Here, we describe, with high temporal resolution, the dynamic landscape of changes in the abundance of proteins synthesized upon
Externí odkaz:
https://doaj.org/article/f6098c0436584283b7ec9f1febaa5510
Autor:
Abhishek Anil Dubey, Anwesha Sarkar, Karolina Milcz, Natalia A Szulc, Pankaj Thapa, Małgorzata Piechota, Remigiusz A Serwa, Wojciech Pokrzywa
Publikováno v:
PLoS Genetics, Vol 20, Iss 7, p e1011371 (2024)
The ubiquitin-proteasome system (UPS) is critical for maintaining proteostasis, influencing stress resilience, lifespan, and thermal adaptability in organisms. In Caenorhabditis elegans, specific proteasome subunits and activators, such as RPN-6, PBS
Externí odkaz:
https://doaj.org/article/3150a55118cd41d0b5c28ec8aaf968af
Autor:
Minji Kim, Remigiusz A. Serwa, Lukasz Samluk, Ida Suppanz, Agata Kodroń, Tomasz M. Stępkowski, Praveenraj Elancheliyan, Biniyam Tsegaye, Silke Oeljeklaus, Michal Wasilewski, Bettina Warscheid, Agnieszka Chacinska
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Perturbed cellular protein homeostasis (proteostasis) and mitochondrial dysfunction play an important role in neurodegenerative diseases, however, the interplay between these two phenomena remains unclear. Mitochondrial dysfunction leads to
Externí odkaz:
https://doaj.org/article/c2fd6721e8ef407e965945401da63108
Autor:
Joanna Małolepsza, Aleksandra Marchwicka, Remigiusz A. Serwa, Sanna P. Niinivehmas, Olli T. Pentikäinen, Edyta Gendaszewska-Darmach, Katarzyna M. Błażewska
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 940-951 (2022)
Rab geranylgeranyltransferase (GGTase-II, RGGT) catalyses the post-translational modification of eukaryotic Rab GTPases, proteins implicated in several pathologies, including cancer, diabetes, neurodegenerative, and infectious diseases. Thus, RGGT in
Externí odkaz:
https://doaj.org/article/47e9fe0a13f242da98a9cbc1518f4bee
Autor:
Maria Sladowska, Michał Turek, Min-Ji Kim, Krzysztof Drabikowski, Ben Hur Marins Mussulini, Karthik Mohanraj, Remigiusz A Serwa, Ulrike Topf, Agnieszka Chacinska
Publikováno v:
PLoS Biology, Vol 19, Iss 7, p e3001302 (2021)
Defects in mitochondrial function activate compensatory responses in the cell. Mitochondrial stress that is caused by unfolded proteins inside the organelle induces a transcriptional response (termed the "mitochondrial unfolded protein response" [UPR
Externí odkaz:
https://doaj.org/article/1e1f62b124cb4c2ba9c4c19570b57648
Autor:
Remigiusz A Serwa, Eiki Sekine, Jonathan Brown, Su Hui Catherine Teo, Edward W Tate, Peter O'Hare
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1007956 (2019)
We report the analysis of a complex enveloped human virus, herpes simplex virus (HSV), assembled after in vivo incorporation of bio-orthogonal methionine analogues homopropargylglycine (HPG) or azidohomoalanine (AHA). We optimised protocols for the p
Externí odkaz:
https://doaj.org/article/e669861661774f14a947b1030a5225df
Autor:
Malgorzata Broncel, Remigiusz A Serwa, Paulina Ciepla, Eberhard Krause, Margaret J. Dallman, Anthony I. Magee, Edward W. Tate
Publikováno v:
Data in Brief, Vol 4, Iss C, Pp 379-383 (2015)
Human cells (HEK 293, HeLa, MCF-7) and zebrafish embryos were metabolically tagged with an alkynyl myristic acid probe, lysed with an SDS buffer and tagged proteomes ligated to multifunctional capture reagents via copper-catalyzed alkyne azide cycloa
Externí odkaz:
https://doaj.org/article/b46e0e25d4cc47ae80460e01c7a10398
Publikováno v:
PLoS Pathogens, Vol 12, Iss 10, p e1005927 (2016)
We used pulse-labeling with the methionine analogue homopropargylglycine (HPG) to investigate spatiotemporal aspects of protein synthesis during herpes simplex virus (HSV) infection. In vivo incorporation of HPG enables subsequent selective coupling
Externí odkaz:
https://doaj.org/article/1bd865252d5845ab9c3bcfe9822c1da9
Autor:
Katarzyna Justyna Chojnacka, Praveenraj Elancheliyan, Ben Hur Marins Mussulini, Karthik Mohanraj, Sylvie Callegari, Aleksandra Gosk, Tomasz Banach, Tomasz Góral, Karolina Szczepanowska, Peter Rehling, Remigiusz Adam Serwa, Agnieszka Chacinska
Publikováno v:
Molecular biology of the cell. 33(4)
Using a combination of techniques (mass spectrometry, BN–PAGE, immunodetection, and mitochondrial in vitro import assays), it is reported that a previously poorly described protein, OCIAD2, localizes to the inner mitochondrial membrane and particip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9782580727545776108364697484305
https://pubmed.ncbi.nlm.nih.gov/35080992
https://pubmed.ncbi.nlm.nih.gov/35080992