Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Remi Patouret"'
Autor:
Remi Patouret, Weilong Liu, Sofia Barluenga, Robbie Loewith, Michael Plank, Nicolas Winssinger
Publikováno v:
ACS Central Science, Vol 7, Iss 6, Pp 954-962 (2021)
ACS Central Science
ACS Central Science, Vol. 7, No 6 (2021) pp. 954-962
ACS Central Science
ACS Central Science, Vol. 7, No 6 (2021) pp. 954-962
Sesquiterpenes are a rich source of covalent inhibitors with a long history in traditional medicine and include several important therapeutics and tool compounds. Herein, we report the total synthesis of 16 sesquiterpene lactones via a build/couple/p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a8641cdfbfd6430c9cecbdb7243ee9
https://doaj.org/article/44cc8bd70d20445e924ae713e56f5b3c
https://doaj.org/article/44cc8bd70d20445e924ae713e56f5b3c
Publikováno v:
Bioorganic & Medicinal Chemistry. 69:116883
Withaferin A, a natural steroidal lactone found in the extracts of Withania somnifera, is used extensively in traditional medicine and part of an ancient remedy in ayurvedic medicine. Prior investigations into its mode of action have shown withaferin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc7f1b1ffa9086f8a43719c76643e41
https://doi.org/10.1016/j.bmc.2022.116883
https://doi.org/10.1016/j.bmc.2022.116883
Publikováno v:
Current Opinion in Chemical Biology, Vol. 39 (2017) pp. 54-63
There is a resurging interest in compounds that engage their target through covalent interactions. Cysteine’s thiol is endowed with enhanced reactivity, making it the nucleophile of choice for covalent engagement with a ligand aligning an electroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f8b3be407f89c15ed2c6b0279ccfec
https://pubmed.ncbi.nlm.nih.gov/28609675
https://pubmed.ncbi.nlm.nih.gov/28609675
Autor:
Weilong Liu, Rémi Patouret, Sofia Barluenga, Michael Plank, Robbie Loewith, Nicolas Winssinger
Publikováno v:
ACS Central Science, Vol 7, Iss 6, Pp 954-962 (2021)
Externí odkaz:
https://doaj.org/article/44cc8bd70d20445e924ae713e56f5b3c
Autor:
Rémi Patouret
Publikováno v:
CHIMIA, Vol 75, Iss 4, Pp 319-322 (2021)
Cellular homeostasis importantly relies on the correct nucleoplasmic distribution of a large number of RNA molecules and proteins, which are shuttled by specialized transport receptors. The nuclear import receptor importin-5, also called IPO5, RanBP5
Externí odkaz:
https://doaj.org/article/a2d86a5cddae47b0bca044222ea64409
Autor:
Timothy S Strutzenberg, Ruben D Garcia-Ordonez, Scott J Novick, HaJeung Park, Mi Ra Chang, Christelle Doebellin, Yuanjun He, Rémi Patouret, Theodore M Kamenecka, Patrick R Griffin
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/b1fd8e202dc64662880de54a651a8517
Autor:
Timothy S Strutzenberg, Ruben D Garcia-Ordonez, Scott J Novick, HaJeung Park, Mi Ra Chang, Christelle Doebellin, Yuanjun He, Rémi Patouret, Theodore M Kamenecka, Patrick R Griffin
Publikováno v:
eLife, Vol 8 (2019)
Members of the nuclear receptor (NR) superfamily regulate both physiological and pathophysiological processes ranging from development and metabolism to inflammation and cancer. Synthetic small molecules targeting NRs are often deployed as therapeuti
Externí odkaz:
https://doaj.org/article/7598ee1869b74d83a7b3c7b8c0a9b36c