Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Remi Fromentin"'
Autor:
Eunok Lee, Peter Bacchetti, Jeffery Milush, Wei Shao, Eli Boritz, Daniel Douek, Remi Fromentin, Teri Liegler, Rebecca Hoh, Steve G. Deeks, Frederick M. Hecht, Nicolas Chomont, Sarah Palmer
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
To date, most assays for measuring the human immunodeficiency virus (HIV-1) reservoir do not include memory CD4+ T-cells expressing the activation marker, human leukocyte antigen-antigen D related (HLA-DR). However, little is known concerning the rol
Externí odkaz:
https://doaj.org/article/377bcc8697144c61b0cfa77b4a969d0c
Autor:
Timothy J Henrich, Hiroyu Hatano, Oliver Bacon, Louise E Hogan, Rachel Rutishauser, Alison Hill, Mary F Kearney, Elizabeth M Anderson, Susan P Buchbinder, Stephanie E Cohen, Mohamed Abdel-Mohsen, Christopher W Pohlmeyer, Remi Fromentin, Rebecca Hoh, Albert Y Liu, Joseph M McCune, Jonathan Spindler, Kelly Metcalf-Pate, Kristen S Hobbs, Cassandra Thanh, Erica A Gibson, Daniel R Kuritzkes, Robert F Siliciano, Richard W Price, Douglas D Richman, Nicolas Chomont, Janet D Siliciano, John W Mellors, Steven A Yukl, Joel N Blankson, Teri Liegler, Steven G Deeks
Publikováno v:
PLoS Medicine, Vol 14, Iss 11, p e1002417 (2017)
BackgroundIt is unknown if extremely early initiation of antiretroviral therapy (ART) may lead to long-term ART-free HIV remission or cure. As a result, we studied 2 individuals recruited from a pre-exposure prophylaxis (PrEP) program who started pro
Externí odkaz:
https://doaj.org/article/7146700700d742c7a0dd1a56e69b9226
Autor:
Sulggi A Lee, Peter Bacchetti, Nicolas Chomont, Remi Fromentin, Sharon R Lewin, Una O'Doherty, Sarah Palmer, Douglas D Richman, Janet D Siliciano, Steven A Yukl, Steven G Deeks, Peter D Burbelo
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160192 (2016)
A major challenge to HIV eradication strategies is the lack of an accurate measurement of the total burden of replication-competent HIV (the "reservoir"). We assessed the association of anti-HIV antibody responses and the estimated size of the reserv
Externí odkaz:
https://doaj.org/article/498b9450506b48bcbf6e3b27f7a7cb95
Autor:
Ole S Søgaard, Mette E Graversen, Steffen Leth, Rikke Olesen, Christel R Brinkmann, Sara K Nissen, Anne Sofie Kjaer, Mariane H Schleimann, Paul W Denton, William J Hey-Cunningham, Kersten K Koelsch, Giuseppe Pantaleo, Kim Krogsgaard, Maja Sommerfelt, Remi Fromentin, Nicolas Chomont, Thomas A Rasmussen, Lars Østergaard, Martin Tolstrup
Publikováno v:
PLoS Pathogens, Vol 11, Iss 9, p e1005142 (2015)
UnlabelledPharmacologically-induced activation of replication competent proviruses from latency in the presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV-1 infection. However, until now, approaches to reverse HI
Externí odkaz:
https://doaj.org/article/c852dcea536446258fe42e2747519f95
Autor:
Caroline Dufour, Corentin Richard, Marion Pardons, Marta Massanella, Antoine Ackaoui, Ben Murrell, Bertrand Routy, Réjean Thomas, Jean-Pierre Routy, Remi Fromentin, Nicolas Chomont
Publikováno v:
Nature Communications. 14
The phenotype of the rare HIV-infected cells persisting during antiretroviral therapies (ART) remains elusive. We developed a single-cell approach that combines the phenotypic analysis of HIV-infected cells with near full-length sequencing of their a
Autor:
Thomas S. Uldrick, Scott V. Adams, Remi Fromentin, Michael Roche, Steven P. Fling, Priscila H. Gonçalves, Kathryn Lurain, Ramya Ramaswami, Chia-ching Jackie Wang, Robert J. Gorelick, Jorden L. Welker, Liz O’Donoghue, Harleen Choudhary, Jeffrey D. Lifson, Thomas A. Rasmussen, Ajantha Rhodes, Carolin Tumpach, Robert Yarchoan, Frank Maldarelli, Martin A. Cheever, Rafick Sékaly, Nicolas Chomont, Steven G. Deeks, Sharon R. Lewin
Publikováno v:
Sci Transl Med
Science translational medicine, vol 14, iss 629
Uldrick, T S, Adams, S V, Fromentin, R, Roche, M, Fling, S P, Gonçalves, P H, Lurain, K, Ramaswami, R, Jackie Wang, C C, Gorelick, R J, Welker, J L, O'Donoghue, L, Choudhary, H, Lifson, J D, Rasmussen, T A, Rhodes, A, Tumpach, C, Yarchoan, R, Maldarelli, F, Cheever, M A, Sékaly, R, Chomont, N, Deeks, S G & Lewin, S R 2022, ' Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy ', Science Translational Medicine, vol. 14, no. 629, eabl3836 . https://doi.org/10.1126/scitranslmed.abl3836
Science translational medicine, vol 14, iss 629
Uldrick, T S, Adams, S V, Fromentin, R, Roche, M, Fling, S P, Gonçalves, P H, Lurain, K, Ramaswami, R, Jackie Wang, C C, Gorelick, R J, Welker, J L, O'Donoghue, L, Choudhary, H, Lifson, J D, Rasmussen, T A, Rhodes, A, Tumpach, C, Yarchoan, R, Maldarelli, F, Cheever, M A, Sékaly, R, Chomont, N, Deeks, S G & Lewin, S R 2022, ' Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy ', Science Translational Medicine, vol. 14, no. 629, eabl3836 . https://doi.org/10.1126/scitranslmed.abl3836
In people living with HIV (PLWH) on antiretroviral therapy (ART), virus persists in a latent form where there is minimal transcription or protein expression. Latently infected cells are a major barrier to curing HIV. Increasing HIV transcription and
Autor:
Caroline Dufour, Maria Julia Ruiz, Amélie Pagliuzza, Corentin Richard, Aniqa Shahid, Rémi Fromentin, Rosalie Ponte, Amélie Cattin, Tomas Raul Wiche Salinas, Syim Salahuddin, Teslin Sandstrom, Stephanie Burke Schinkel, Cecilia T. Costiniuk, Mohammad-Ali Jenabian, Petronela Ancuta, Jean-Pierre Routy, Éric A. Cohen, Zabrina L. Brumme, Christopher Power, Jonathan B. Angel, Nicolas Chomont
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113053- (2023)
Summary: HIV persists in tissues during antiretroviral therapy (ART), but the relative contribution of different anatomical compartments to the viral reservoir in humans remains unknown. We performed an extensive characterization of HIV reservoirs in
Externí odkaz:
https://doaj.org/article/e4e8b6c77a184552ad1a6aff83a1287f
Autor:
Mariela P. Cabral-Piccin, Laura Papagno, Xavier Lahaye, Federico Perdomo-Celis, Stevenn Volant, Eoghann White, Valérie Monceaux, Sian Llewellyn-Lacey, Rémi Fromentin, David A. Price, Nicolas Chomont, Nicolas Manel, Asier Saez-Cirion, Victor Appay
Publikováno v:
EBioMedicine, Vol 91, Iss , Pp 104557- (2023)
Summary: Background: CD8+ T cells equipped with a full arsenal of antiviral effector functions are critical for effective immune control of HIV-1. It has nonetheless remained unclear how best to elicit such potent cellular immune responses in the con
Externí odkaz:
https://doaj.org/article/9f64fa34ed76468ea4127a248fbf1ab6
Autor:
Chris Y. Chiu, Maya D. Schou, James H. McMahon, Steven G. Deeks, Rémi Fromentin, Nicolas Chomont, Michelle N. Wykes, Thomas A. Rasmussen, Sharon R. Lewin
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionIn people with HIV (PWH) both off and on antiretroviral therapy (ART), the expression of immune checkpoint (IC) proteins is elevated on the surface of total and HIV-specific T-cells, indicating T-cell exhaustion. Soluble IC proteins and t
Externí odkaz:
https://doaj.org/article/64a3fccd9520467d87cf447a13d006fc
Autor:
Gabriel Duette, Bonnie Hiener, Hannah Morgan, Fernando G. Mazur, Vennila Mathivanan, Bethany A. Horsburgh, Katie Fisher, Orion Tong, Eunok Lee, Haelee Ahn, Ansari Shaik, Rémi Fromentin, Rebecca Hoh, Charline Bacchus-Souffan, Najla Nasr, Anthony L. Cunningham, Peter W. Hunt, Nicolas Chomont, Stuart G. Turville, Steven G. Deeks, Anthony D. Kelleher, Timothy E. Schlub, Sarah Palmer
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 7 (2022)
Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular populations that contribute to the HIV-1 reservoir and understand
Externí odkaz:
https://doaj.org/article/e7d25a389c024bd794a8bffa17580540