The value of bioactive adrenomedullin and dipeptidyl peptidase 3 to predict short-term unfavourable outcomes after cardiac surgery: A prospective cohort study

Autor: Dirk van Lier, Remi Beunders, Matthijs Kox, Peter Pickkers

Publikováno v: European Journal of Anaesthesiology, 39, 4, pp. 342-351
European Journal of Anaesthesiology, 39, 342-351

Adrenomedullin (ADM) is a key regulator of endothelial barrier function and vascular tone. Dipeptidyl peptidase 3 (DPP3) is a protease involved in the degradation of several cardiovascular mediators. Increased levels of bioactive ADM (bio-ADM) and ci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc78dca291f087a8a870abb2ccd1b85
https://hdl.handle.net/2066/252123

Safety and Efficacy of Human Chorionic Gonadotropin Hormone-Derivative EA-230 in Cardiac Surgery Patients: A Randomized Double-Blind Placebo-Controlled Study

Autor: Jelle Gerretsen, Denise Waanders, Johannes G. van der Hoeven, Remi Beunders, Leonie S. E. Buijsse, Matthijs Kox, Emma J. Kooistra, Pleun Hemelaar, Lucas T. van Eijk, Roger van Groenendael, Jan Hofland, Maud G. A. Lamberts, Wim J. Morshuis, Wout J. Claassen, Gert Wensvoort, Peter Pickkers

Publikováno v: van Groenendael, R, Beunders, R, Hemelaar, P, Hofland, J, Morshuis, W J, van der Hoeven, J G, Gerretsen, J, Wensvoort, G, Kooistra, E J, Claassen, W J, Waanders, D, Lamberts, M G A, Buijsse, L S E, Kox, M, van Eijk, L T & Pickkers, P 2021, ' Safety and Efficacy of Human Chorionic Gonadotropin Hormone-Derivative EA-230 in Cardiac Surgery Patients: A Randomized Double-Blind Placebo-Controlled Study ', Critical Care Medicine, pp. 790-803 . https://doi.org/10.1097/CCM.0000000000004847
Critical Care Medicine
Critical Care Medicine, 790-803. Lippincott Williams and Wilkins
STARTPAGE=790;ENDPAGE=803;ISSN=0090-3493;TITLE=Critical Care Medicine
Critical Care Medicine, 49, 790-803
Critical Care Medicine, 49, 5, pp. 790-803

Supplemental Digital Content is available in the text.
OBJECTIVES: To determine the safety and efficacy of human chorionic gonadotropin hormone-derivative EA-230 in cardiac surgery patients. Cardiac surgery induces systemic inflammation and may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9af3097db36351721afd314214afd6e
https://hdl.handle.net/2066/232791

Proenkephalin as a new biomarker for pediatric acute kidney injury - reference values and performance in children under one year of age

Autor: Joost van Rosmalen, Nadies E C van de Water, Michiel F. Schreuder, Dick Tibboel, Saskia N. de Wildt, Stan J. F. Hartman, Oliver Hartmann, Joachim Struck, Janin Schulte, Remi Beunders, Peter Pickkers, Alexandra J M Zwiers

Publikováno v: Clinical Chemistry and Laboratory Medicine, 58(11), 1911-1919. De Gruyter
Clinical Chemistry and Laboratory Medicine, 58, 11, pp. 1911-1919
Clinical Chemistry and Laboratory Medicine, 58, 1911-1919

Objectives Acute kidney injury (AKI) is common in critically ill children, but current biomarkers are suboptimal. Proenkephalin A 119–159 (PENK) is a promising new biomarker for AKI in adults, but pediatric data is lacking. We determined PENK refer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bf6e0a888c3bb55af8a231be42f450
https://doi.org/10.1515/cclm-2020-0381

Reply to Chapman et al

Autor: Peter Pickkers, Remi Beunders, Coen C. W. G. Bongers

Publikováno v: Journal of Applied Physiology, 129, 1
Journal of Applied Physiology, 129

Contains fulltext : 224865.pdf (Publisher’s version ) (Closed access)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5241d5964760e913ac8a8eaf51a7b4fb
https://doi.org/10.1152/japplphysiol.00464.2020

Proenkephalin Compared to Conventional Methods to Assess Kidney Function in Critically Ill Sepsis Patients

Autor: Remi Beunders, Matthijs Kox, Roger van Groenendael, Guus P. Leijte, Peter Pickkers

Publikováno v: Shock (Augusta, Ga.)
Shock, 54, 308-314
Shock, 54, 3, pp. 308-314

Contains fulltext : 225495.pdf (Publisher’s version ) (Open Access) BACKGROUND: The assessment of renal function in clinical practice remains challenging. Using creatinine to assess the glomerular filtration rate (GFR) is notoriously inaccurate, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f1f5756637abf3b029bf4ff6551912
https://doi.org/10.1097/SHK.0000000000001510