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The modification of the thrombin generation assay for the clinical assessment of hypercoagulability in patients receiving heparin therapy

Autor: Christophe Nougier, Remi Benoit, Yesim Dargaud, Hélène Desmurs-Clavel, Marie Simon

Publikováno v: International Journal of Laboratory Hematology. 44:371-378

Background Heparin diminishes thrombin generation (TG) because it decreases the survival time of thrombin in plasma. Under heparin therapy, the TG curve therefore does not reflect the true hemostatic status of the patient. Aim We investigated how far

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbb9955039f33d0e55baea6666468d6
https://doi.org/10.1111/ijlh.13735

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Response to 'Studies on hemostasis in COVID‐19 deserve careful reporting of the laboratory methods, their significance and their limitation': Don’t throw the baby out with the bathwater

Autor: Remi Benoit, Christophe Nougier, Yesim Dargaud

Publikováno v: Journal of Thrombosis and Haemostasis

We appreciate the opportunity to respond to the letter from Dr Hardy and colleagues (1). The authors stress on the large variability observed between different anti-Xa kits available on the market, they contest our results of thrombin generation assa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936ce0251892ddeda2f6eda8a1aaffb0
https://doi.org/10.1111/jth.15086

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Hypofibrinolytic state and high thrombin generation may play a major role in SARS‐COV2 associated thrombosis

Autor: Guillaume Marcotte, Remi Benoit, Marie Simon, Helene Desmurs-Clavel, Yesim Dargaud, Claude Negrier, Laurent Argaud, Christophe Nougier, Jean Stephane David, Aurelie Bonnet

Publikováno v: Journal of Thrombosis and Haemostasis
Journal of thrombosis and haemostasis : JTH
Journal of thrombosis and haemostasis : JTH, 2020, ⟨10.1111/jth.15016⟩

Background Thirty percent of Covid-19 patients admitted to intensive care units present with thrombotic complications despite thromboprophylaxis. Bed rest, obesity, hypoxia, coagulopathy, and acute excessive inflammation are potential mechanisms repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b034ea0d7a34de0f19b1164aa6b8647

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