Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Remco M. Hoogenboezem"'
Autor:
Boris J.B. Beudeker, Zgjim Osmani, Gertine W. van Oord, Zwier M.A. Groothuismink, Robert J. de Knegt, Remco M. Hoogenboezem, Eric M.J. Bindels, Harmen J.G. van de Werken, Andre Boonstra
Publikováno v:
JHEP Reports, Vol 6, Iss 2, Pp 100980- (2024)
Background & Aims: HBsAg secretion may impact immune responses to chronic HBV infection. Thus, therapeutic approaches to suppress HBsAg production are being investigated. Our study aims to examine the immunomodulatory effects of high and low levels o
Externí odkaz:
https://doaj.org/article/542efaeae0b24074ae10f0b1e8f00943
Autor:
Jacqueline Feyen, Zhen Ping, Lanpeng Chen, Claire van Dijk, Tim V. D. van Tienhoven, Paulina M. H. van Strien, Remco M. Hoogenboezem, Michiel J. W. Wevers, Mathijs A. Sanders, Ivo P. Touw, Marc H. G. P. Raaijmakers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Innate and adaptive immune cells function in the homeostasis of haematopoietic stem cells (HSC). Here the authors show that myeloid cells are able to reduce the function of HSCs via interferon signaling through a neutrophil-NK cell dependent process.
Externí odkaz:
https://doaj.org/article/9f3d9e52bb044dac844af641eab95cd4
Autor:
Patricia A. Olofsen, Szabolcs Fatrai, Paulina M.H. van Strien, Julia C. Obenauer, Hans W.J. de Looper, Remco M. Hoogenboezem, Claudia A.J. Erpelinck-Verschueren, Michael P.W.M. Vermeulen, Onno Roovers, Torsten Haferlach, Joop H. Jansen, Mehrnaz Ghazvini, Eric M.J. Bindels, Rebekka K. Schneider, Emma M. de Pater, Ivo P. Touw
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 5, Pp 100074- (2020)
Summary: Severe congenital neutropenia (SCN) patients treated with CSF3/G-CSF to alleviate neutropenia frequently develop acute myeloid leukemia (AML). A common pattern of leukemic transformation involves the appearance of hematopoietic clones with C
Externí odkaz:
https://doaj.org/article/a0e7d0f08d2e4c29ae248feba801718a
Autor:
Mónica Romera-Hernández, Patricia Aparicio-Domingo, Natalie Papazian, Julien J. Karrich, Ferry Cornelissen, Remco M. Hoogenboezem, Janneke N. Samsom, Tom Cupedo
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 37-45.e3 (2020)
Summary: Tissue repair requires temporal control of progenitor cell proliferation and differentiation to replenish damaged cells. In response to acute insult, group 3 innate lymphoid cells (ILC3s) regulate intestinal stem cell maintenance and subsequ
Externí odkaz:
https://doaj.org/article/f021e4d347bb43218291a70345aa1a58
Autor:
Priya Chudasama, Sadaf S. Mughal, Mathijs A. Sanders, Daniel Hübschmann, Inn Chung, Katharina I. Deeg, Siao-Han Wong, Sophie Rabe, Mario Hlevnjak, Marc Zapatka, Aurélie Ernst, Kortine Kleinheinz, Matthias Schlesner, Lina Sieverling, Barbara Klink, Evelin Schröck, Remco M. Hoogenboezem, Bernd Kasper, Christoph E. Heilig, Gerlinde Egerer, Stephan Wolf, Christof von Kalle, Roland Eils, Albrecht Stenzinger, Wilko Weichert, Hanno Glimm, Stefan Gröschel, Hans-Georg Kopp, Georg Omlor, Burkhard Lehner, Sebastian Bauer, Simon Schimmack, Alexis Ulrich, Gunhild Mechtersheimer, Karsten Rippe, Benedikt Brors, Barbara Hutter, Marcus Renner, Peter Hohenberger, Claudia Scholl, Stefan Fröhling
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The molecular genetic landscape of leiomyosarcoma (LMS) is largely unknown. Here, the authors identify frequent DNA copy number alterations, whole-genome duplication, TP53 and RB1 inactivation, alternative telomere lengthening, and genomic imprints o
Externí odkaz:
https://doaj.org/article/d4d8c497353f4a34a7f3673b1d82cb28
Autor:
Yotam E. Bar-Ephraim, Ferry Cornelissen, Natalie Papazian, Tanja Konijn, Remco M. Hoogenboezem, Mathijs A. Sanders, Bart A. Westerman, Mehmet Gönültas, Jaap Kwekkeboom, Joke M.M. Den Haan, Rogier M. Reijmers, Reina E. Mebius, Tom Cupedo
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 823-833 (2017)
A substantial number of human and mouse group 3 innate lymphoid cells (ILC3s) reside in secondary lymphoid organs, yet the phenotype and function of these ILC3s is incompletely understood. Here, we employed an unbiased cross-tissue transcriptomic app
Externí odkaz:
https://doaj.org/article/2052fe975f11466bbffd54387d2953fa
Autor:
Julia C. Obenauer, François G. Kavelaars, Mathijs A. Sanders, Remco M. Hoogenboezem, Andrica C. H. de Vries, Paulina M. H. van Strien, Valerie de Haas, Franco Locatelli, Henrik Hasle, Peter J. M. Valk, Ivo P. Touw, Marry M. van den Heuvel-Eibrink
Publikováno v:
Haematologica, Vol 101, Iss 12 (2016)
Externí odkaz:
https://doaj.org/article/680adc3a9ebc438cb6ed10e926091cf3
Autor:
Noemi A. Zambetti, Eric M. J. Bindels, Paulina M. H. Van Strien, Marijke G. Valkhof, Maria N. Adisty, Remco M. Hoogenboezem, Mathijs A. Sanders, Johanna M. Rommens, Ivo P. Touw, Marc H. G. P. Raaijmakers
Publikováno v:
Haematologica, Vol 100, Iss 10 (2015)
Shwachman-Diamond syndrome is a congenital bone marrow failure disorder characterized by debilitating neutropenia. The disease is associated with loss-of-function mutations in the SBDS gene, implicated in ribosome biogenesis, but the cellular and mol
Externí odkaz:
https://doaj.org/article/bd2c443f30e24086ae9bd6bbe5c5cac0
Autor:
Patricia A. Olofsen, Dennis A. Bosch, Hans W. J. de Looper, Paulina M. H. van Strien, Remco M. Hoogenboezem, Onno Roovers, Vincent H. J. van der Velden, Eric M. J. Bindels, Emma M. De Pater, Ivo P. Touw
Publikováno v:
British Journal of Haematology, 200(1), 79-86. Wiley-Blackwell Publishing Ltd
Severe congenital neutropenia (SCN) patients are prone to develop myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML). Leukaemic progression of SCN is associated with the early acquisition of CSF3R mutations in haematopoietic progenitor c
Autor:
Andrew L. H. Webster, Mathijs A. Sanders, Krupa Patel, Ralf Dietrich, Raymond J. Noonan, Francis P. Lach, Ryan R. White, Audrey Goldfarb, Kevin Hadi, Matthew M. Edwards, Frank X. Donovan, Remco M. Hoogenboezem, Moonjung Jung, Sunandini Sridhar, Tom F. Wiley, Olivier Fedrigo, Huasong Tian, Joel Rosiene, Thomas Heineman, Jennifer A. Kennedy, Lorenzo Bean, Rasim O. Rosti, Rebecca Tryon, Ashlyn-Maree Gonzalez, Allana Rosenberg, Ji-Dung Luo, Thomas S. Carroll, Sanjana Shroff, Michael Beaumont, Eunike Velleuer, Jeff C. Rastatter, Susanne I. Wells, Jordi Surrallés, Grover Bagby, Margaret L. MacMillan, John E. Wagner, Maria Cancio, Farid Boulad, Theresa Scognamiglio, Roger Vaughan, Kristin G. Beaumont, Amnon Koren, Marcin Imielinski, Settara C. Chandrasekharappa, Arleen D. Auerbach, Bhuvanesh Singh, David I. Kutler, Peter J. Campbell, Agata Smogorzewska
Publikováno v:
Nature, 612(7940), 495-502. Nature Publishing Group
Nature
Nature
Fanconi anaemia (FA), a model syndrome of genome instability, is caused by a deficiency in DNA interstrand crosslink repair resulting in chromosome breakage1–3. The FA repair pathway protects against endogenous and exogenous carcinogenic aldehydes4