Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Remco M Hoogenboezem"'
Autor:
Manzhi Zhao, Caoimhe H Kiernan, Christopher J Stairiker, Jennifer L Hope, Leticia G Leon, Marjan van Meurs, Inge Brouwers-Haspels, Ruben Boers, Joachim Boers, Joost Gribnau, Wilfred F J van IJcken, Eric M Bindels, Remco M Hoogenboezem, Stefan J Erkeland, Yvonne M Mueller, Peter D Katsikis
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008555 (2020)
Exhaustion is a dysfunctional state of cytotoxic CD8+ T cells (CTL) observed in chronic infection and cancer. Current in vivo models of CTL exhaustion using chronic viral infections or cancer yield very few exhausted CTL, limiting the analysis that c
Externí odkaz:
https://doaj.org/article/0638732910034e3dbdc1bc9fe44b7d9d
Autor:
Boris J.B. Beudeker, Zgjim Osmani, Gertine W. van Oord, Zwier M.A. Groothuismink, Robert J. de Knegt, Remco M. Hoogenboezem, Eric M.J. Bindels, Harmen J.G. van de Werken, Andre Boonstra
Publikováno v:
JHEP Reports, Vol 6, Iss 2, Pp 100980- (2024)
Background & Aims: HBsAg secretion may impact immune responses to chronic HBV infection. Thus, therapeutic approaches to suppress HBsAg production are being investigated. Our study aims to examine the immunomodulatory effects of high and low levels o
Externí odkaz:
https://doaj.org/article/542efaeae0b24074ae10f0b1e8f00943
Autor:
Titia G. Meijer, John W. M. Martens, Wendy J. C. Prager-van der Smissen, Nicole S. Verkaik, Corine M. Beaufort, Stanley van Herk, Teresa Robert-Finestra, Remco M. Hoogenboezem, Kirsten Ruigrok-Ritstier, Maarten W. Paul, Joost Gribnau, Eric M. J. Bindels, Roland Kanaar, Agnes Jager, Dik C. van Gent, Antoinette Hollestelle
Publikováno v:
Cancers, Vol 16, Iss 4, p 741 (2024)
Tumors with a pathogenic BRCA1/2 mutation are homologous recombination (HR)-deficient (HRD) and consequently sensitive to platinum-based chemotherapy and Poly-[ADP-Ribose]-Polymerase inhibitors (PARPi). We hypothesized that functional HR status bette
Externí odkaz:
https://doaj.org/article/f0adf102e7004b4299d9e0559ed350c1
Autor:
Jacqueline Feyen, Zhen Ping, Lanpeng Chen, Claire van Dijk, Tim V. D. van Tienhoven, Paulina M. H. van Strien, Remco M. Hoogenboezem, Michiel J. W. Wevers, Mathijs A. Sanders, Ivo P. Touw, Marc H. G. P. Raaijmakers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Innate and adaptive immune cells function in the homeostasis of haematopoietic stem cells (HSC). Here the authors show that myeloid cells are able to reduce the function of HSCs via interferon signaling through a neutrophil-NK cell dependent process.
Externí odkaz:
https://doaj.org/article/9f3d9e52bb044dac844af641eab95cd4
Autor:
Patricia A. Olofsen, Dennis A. Bosch, Hans W. J. de Looper, Paulina M. H. van Strien, Remco M. Hoogenboezem, Onno Roovers, Vincent H. J. van der Velden, Eric M. J. Bindels, Emma M. De Pater, Ivo P. Touw
Publikováno v:
British Journal of Haematology, 200(1), 79-86. Wiley-Blackwell Publishing Ltd
Severe congenital neutropenia (SCN) patients are prone to develop myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML). Leukaemic progression of SCN is associated with the early acquisition of CSF3R mutations in haematopoietic progenitor c
Autor:
Andrew L. H. Webster, Mathijs A. Sanders, Krupa Patel, Ralf Dietrich, Raymond J. Noonan, Francis P. Lach, Ryan R. White, Audrey Goldfarb, Kevin Hadi, Matthew M. Edwards, Frank X. Donovan, Remco M. Hoogenboezem, Moonjung Jung, Sunandini Sridhar, Tom F. Wiley, Olivier Fedrigo, Huasong Tian, Joel Rosiene, Thomas Heineman, Jennifer A. Kennedy, Lorenzo Bean, Rasim O. Rosti, Rebecca Tryon, Ashlyn-Maree Gonzalez, Allana Rosenberg, Ji-Dung Luo, Thomas S. Carroll, Sanjana Shroff, Michael Beaumont, Eunike Velleuer, Jeff C. Rastatter, Susanne I. Wells, Jordi Surrallés, Grover Bagby, Margaret L. MacMillan, John E. Wagner, Maria Cancio, Farid Boulad, Theresa Scognamiglio, Roger Vaughan, Kristin G. Beaumont, Amnon Koren, Marcin Imielinski, Settara C. Chandrasekharappa, Arleen D. Auerbach, Bhuvanesh Singh, David I. Kutler, Peter J. Campbell, Agata Smogorzewska
Publikováno v:
Nature, 612(7940), 495-502. Nature Publishing Group
Nature
Nature
Fanconi anaemia (FA), a model syndrome of genome instability, is caused by a deficiency in DNA interstrand crosslink repair resulting in chromosome breakage1–3. The FA repair pathway protects against endogenous and exogenous carcinogenic aldehydes4
Autor:
Shuang Zhang, Bastiaan Tuk, Jeroen van de Peppel, Gert-Jan Kremers, Marijke Koedam, Georg R. Pesch, Zaid Rahman, Remco M. Hoogenboezem, Eric M.J. Bindels, Johan W. van Neck, Pouyan E. Boukany, Johannes P.T.M. van Leeuwen, Bram C.J. van der Eerden
Publikováno v:
Acta Biomaterialia, 151, 346-359. Elsevier
Acta Biomaterialia, 151
Acta Biomaterialia, 151
A functional vascular system is a prerequisite for bone repair as disturbed angiogenesis often causes non-union. Paracrine factors released from human bone marrow derived mesenchymal stromal cells (BMSCs) have angiogenic effects on endothelial cells.
Autor:
Patricia A. Olofsen, Szabolcs Fatrai, Paulina M.H. van Strien, Julia C. Obenauer, Hans W.J. de Looper, Remco M. Hoogenboezem, Claudia A.J. Erpelinck-Verschueren, Michael P.W.M. Vermeulen, Onno Roovers, Torsten Haferlach, Joop H. Jansen, Mehrnaz Ghazvini, Eric M.J. Bindels, Rebekka K. Schneider, Emma M. de Pater, Ivo P. Touw
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 5, Pp 100074- (2020)
Summary: Severe congenital neutropenia (SCN) patients treated with CSF3/G-CSF to alleviate neutropenia frequently develop acute myeloid leukemia (AML). A common pattern of leukemic transformation involves the appearance of hematopoietic clones with C
Externí odkaz:
https://doaj.org/article/a0e7d0f08d2e4c29ae248feba801718a
Autor:
Mónica Romera-Hernández, Patricia Aparicio-Domingo, Natalie Papazian, Julien J. Karrich, Ferry Cornelissen, Remco M. Hoogenboezem, Janneke N. Samsom, Tom Cupedo
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 37-45.e3 (2020)
Summary: Tissue repair requires temporal control of progenitor cell proliferation and differentiation to replenish damaged cells. In response to acute insult, group 3 innate lymphoid cells (ILC3s) regulate intestinal stem cell maintenance and subsequ
Externí odkaz:
https://doaj.org/article/f021e4d347bb43218291a70345aa1a58
Autor:
Yotam E. Bar-Ephraim, Ferry Cornelissen, Natalie Papazian, Tanja Konijn, Remco M. Hoogenboezem, Mathijs A. Sanders, Bart A. Westerman, Mehmet Gönültas, Jaap Kwekkeboom, Joke M.M. Den Haan, Rogier M. Reijmers, Reina E. Mebius, Tom Cupedo
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 823-833 (2017)
A substantial number of human and mouse group 3 innate lymphoid cells (ILC3s) reside in secondary lymphoid organs, yet the phenotype and function of these ILC3s is incompletely understood. Here, we employed an unbiased cross-tissue transcriptomic app
Externí odkaz:
https://doaj.org/article/2052fe975f11466bbffd54387d2953fa