Evaluating intra-action reviews at points of entry: ongoing learning opportunities during the COVID-19 pandemic

Autor: Doret de Rooij, Miriam van de Watering, Remco van Dijk, Thijs Veenstra, Rolf Appels, Corien Swaan, Aura Timen

Publikováno v: BMC Public Health, Vol 23, Iss 1, Pp 1-13 (2023)

Abstract Background Long-lasting crises, such as the COVID-19 pandemic, require proper interim evaluation in order to optimize response. The World Health Organization and the European Center for Disease Control have recently promoted the in(tra)-acti

Externí odkaz: https://doaj.org/article/8ebda7996f10439fac5565ba0e0731c8

Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo

Autor: Remco van Dijk, Sem J. Aronson, Dirk R. de Waart, Stan F. van de Graaf, Suzanne Duijst, Jurgen Seppen, Ronald Oude Elferink, Ulrich Beuers, Piter J. Bosma

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract We aimed to identify potent biliverdin reductase (BVRA) inhibitors as a novel concept for the treatment of severe unconjugated hyperbilirubinemia. 1280 FDA-approved compounds were screened in vitro for their ability to inhibit human and rat

Externí odkaz: https://doaj.org/article/d12f4548a8564f6a914ed21b89937903

A Quantitative In Vitro Potency Assay for Adeno-Associated Virus Vectors Encoding for the UGT1A1 Transgene

Autor: Giulia Bortolussi, Giuseppe Ronzitti, Lysbeth ten Bloemendaal, Piter J. Bosma, Andrés F. Muro, Robert S. Bakker, Xiaoxia Shi, Remco van Dijk, Federico Mingozzi, Fanny Collaud, Suzanne Duijst, Sem J. Aronson, Ulrich Beuers, Sascha Moenis

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 250-258 (2020)
Molecular Therapy-Methods & Clinical Development
Molecular therapy. Methods & clinical development, 18, 250-258. Nature Publishing Group

Potency assessment of clinical-grade vector lots is crucial to support adeno-associated virus (AAV) vector release and is required for future marketing authorization. We have developed and validated a cell-based, quantitative potency assay that detec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffb2207bb4b88df05c15b06a9c6750b
http://www.scopus.com/inward/record.url?scp=85086934701&partnerID=8YFLogxK

Disruption of HNF1α binding site causes inherited severe unconjugated hyperbilirubinemia

Autor: Vincent A. van der Mark, Isabel Mayayo-Peralta, Piter J. Bosma, Ulrich Beuers, Sem J. Aronson, Nevin Oruc, Rob J. de Knegt, Remco van Dijk, Anja A. Kattentidt-Mouravieva

Publikováno v: Journal of hepatology, 63(6), 1525-1529. Elsevier
Journal of Hepatology, 63(6), 1525-1529. Elsevier

Crigler-Najjar syndrome presents as severe unconjugated hyper-bilirubinemia and is characteristically caused by a mutation in the UGT1A1 gene, encoding the enzyme responsible for bilirubin glucuronidation. Here we present a patient with Crigler-Najja

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7440566a30328068e9d806674c57f6
https://doi.org/10.1016/j.jhep.2015.07.027

Erratum to: Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4

Autor: Zoë Castricum, Remco van Dijk, Wouter J. de Jonge, Casper Marsman, Kam S. Ho-Mok, Coen C. Paulusma, Mohammed Ghiboub, Vincent A. van der Mark, Jing Zhao, Johan K. Hiralall, Ronald P.J. Oude Elferink

Publikováno v: Cellular and Molecular Life Sciences

P4-ATPases are lipid flippases that catalyze the transport of phospholipids to create membrane phospholipid asymmetry and to initiate the biogenesis of transport vesicles. Here we show, for the first time, that lipid flippases are essential to dampen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b65868e1039a84fad19e8e09ca544446