Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rembert, Elbers"'
Autor:
Kerstin, Westermark, Birthe Byskov, Holm, Mirjam, Söderholm, Jordi, Llinares-Garcia, Frida, Rivière, Stiina, Aarum, Florence, Butlen-Ducuing, Stelios, Tsigkos, Agnieszka, Wilk-Kachlicka, Cinzia, N'Diamoi, János, Borvendég, David, Lyons, Bruno, Sepodes, Brigitte, Bloechl-Daum, André, Lhoir, Mariana, Todorova, Ioannis, Kkolos, Kateřina, Kubáčková, Heidrun, Bosch-Traberg, Vallo, Tillmann, Veijo, Saano, Emmanuel, Héron, Rembert, Elbers, Miranda, Siouti, Judit, Eggenhofer, Patrick, Salmon, Maurizio, Clementi, Dainis, Krieviņš, Aušra, Matulevičiene, Henri, Metz, Albert Cilia, Vincenti, Albertha, Voordouw, Bożenna, Dembowska-Bagińska, Ana Corrêa, Nunes, Flavia Mirela, Saleh, Tatiana, Foltánová, Martin, Možina, Josep, Torrent i Farnell, Björn, Beerman, Segundo, Mariz, Marie Pauline, Evers, Lesley, Greene, Sigurdur, Thorsteinsson, Lars, Gramstad, Maria, Mavris, Fabrizia, Bignami, Annie, Lorence, Chantal, Belorgey
Publikováno v:
Nature reviews. Drug discovery. 10(5)
In 2000, regulation on orphan medicinal products was adopted in the European Union with the aim of benefiting patients who suffer from serious, rare conditions for which there is currently no satisfactory treatment. Since then, more than 850 orphan d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89d8998cffc4d17daac011c4aa2f5623
https://pubmed.ncbi.nlm.nih.gov/21532564
https://pubmed.ncbi.nlm.nih.gov/21532564
Autor:
Rolf Bass, Rembert Elbers
Publikováno v:
Drug Information Journal. 27:87-94
Germany's experience with the concertation procedure has been fairly successful. This paper compares the time frame for approval of applications through the concertation procedure to multi-state procedures and national procedures. Although Germany ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39bb90a5e77a95837236f4a0ddfb3569
https://doi.org/10.1177/009286159302700118
https://doi.org/10.1177/009286159302700118
Autor:
Tatiana Foltanova, Albertha Voordouw, Laura Fregonese, Bruno Sepodes, André Lhoir, Segundo Mariz, Daniel O’Connor, Jordi Llinares, Stelios Tsigkos, Pauline J Evers, Bożenna Dembowska-Bagińska, Ana Corrêa-Nunes, Kerstin Westermark, Rembert Elbers, Stiina Aarum
Publikováno v:
Orphanet Journal of Rare Diseases
The use of biomarkers within the procedures of the Committee of Orphan Medicinal Products (COMP) of the European Medicines Agency (EMA) is discussed herein. The applications for Orphan Medicinal Product designation in the EU are evaluated at two stag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96538163b912d4dee7bc23aa613fa7bc
http://europepmc.org/articles/PMC3907589
http://europepmc.org/articles/PMC3907589
Publikováno v:
Biochemical Pharmacology. 29:1747-1753
To evaluate the influence of 4-dimethylaminophenol (DMAP) on cellular intermediary metabolism, isolated rat livers were single pass perfused with subtoxic (0.3 mM) and toxic (1 mM) concentrations of DMAP. The rate of glycolysis and oxygen consumption
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfaef895cf6f758d94c073213908ac5
https://doi.org/10.1016/0006-2952(80)90135-5
https://doi.org/10.1016/0006-2952(80)90135-5
Publikováno v:
Psychiatry Research. 15:41-48
The specific binding of the dopamine antagonist 3H-spiperone to lymphocytes from a healthy control group (n = 40), a group of acute, unmedicated schizophrenic patients (n = 27), and a psychiatric control group (n = 16) was investigated. There were no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ad4ee1ec03cdf087b201b1e299b64f
https://doi.org/10.1016/0165-1781(85)90038-1
https://doi.org/10.1016/0165-1781(85)90038-1
Publikováno v:
Hoppe-Seyler's Zeitschrift fur physiologische Chemie. 355(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1988dd1716e11596026dfa0818591c99
https://pubmed.ncbi.nlm.nih.gov/4154892
https://pubmed.ncbi.nlm.nih.gov/4154892
Publikováno v:
Biological Reactive Intermediates—II ISBN: 9781475706765
Toxication of xenobiotics by intracellular activation to potent alkylating or arylating agents has been observed in several classes of drugs. For N-acetamidophenols, transformation into reactive intermediates by a cytochrome P-450 mixed function oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ba48b6546a9d4976669976d957a143d
https://doi.org/10.1007/978-1-4757-0674-1_30
https://doi.org/10.1007/978-1-4757-0674-1_30
Publisher Summary This chapter discusses metabolite measurements in mitochondria and in the extramitochondrial compartment by fractionation of freeze-stopped liver tissue in nonaqueous media. The investigation of cellular metabolism requires insight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16a6254d2f9754798332c5e2f623deec
https://doi.org/10.1016/0076-6879(79)56022-4
https://doi.org/10.1016/0076-6879(79)56022-4
Publikováno v:
Hoppe-Seyler's Zeitschrift fur physiologische Chemie. 361(1)
The subcellular distribution of malate, 2-oxoglutarate, citrate, aspartate and glutamate and the mitochondrial and cytosolic pH values were determined in perfused livers from fed and fasted rats. The method of fractionation of the freeze-dried tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470ce003ab7580250bb72d4b74aabe1d
https://pubmed.ncbi.nlm.nih.gov/7358333
https://pubmed.ncbi.nlm.nih.gov/7358333
Publikováno v:
Biochemical pharmacology. 35(13)
The intestinal first pass metabolism of amygdalin has been investigated in rat small intestine in vitro. The results show that amygdalin is hydrolyzed to prunasin, essentially in the wall of the proximal jejunum. This specific beta(1-6)hydrolytic cle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19486815e15c99be1ac4c2247ff3528b
https://pubmed.ncbi.nlm.nih.gov/3089225
https://pubmed.ncbi.nlm.nih.gov/3089225