Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Remacemide"'
Publikováno v:
Drug Design, Development and Therapy. 10:3633-3651
Phenytoin (PHT), valproic acid, and modern antiepileptic drugs (AEDs), eg, remacemide, loreclezole, and safinamide, are only effective within a maximum of 70%-80% of epileptic patients, and in many cases the clinical use of AEDs is restricted by thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7a48f10409d48f1893010d611e4790b
https://doi.org/10.2147/dddt.s114147
https://doi.org/10.2147/dddt.s114147
Autor:
Kelly L. Andrzejewski, Madhurima Majumder, Elisabeth A. de Blieck, Michael P. McDermott, Merit Cudkowicz, Haruhiko Banno, Peggy Auinger, Alyssa Murphy, Nazem Atassi
Publikováno v:
Journal of Huntington's disease. 6(2)
BACKGROUND Excellent retention in Huntington disease (HD) clinical trials is essential for testing new therapies. The stage of disease, cognitive status, and availability of a care partner may influence retention in HD clinical trials. OBJECTIVE We s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91e1e8e235992d21dbfb9cb0a8d2b98
https://pubmed.ncbi.nlm.nih.gov/28922164
https://pubmed.ncbi.nlm.nih.gov/28922164
Autor:
Wallach, Jason, Colestock, Tristan, Agramunt, Julià, Claydon, Matt, Dybek, Michael, Filemban, Nathalie, Chatha, Muhammad, Halberstadt, Adam L., Brandt, Simon, Lodge, David, Bortolotto, Zuner A, Adejare, Adeboye
Publikováno v:
Wallach, J, Colestock, T, Agramunt, J, Claydon, M, Dybek, M, Filemban, N, Chatha, M, Halberstadt, A L, Halberstadt, A L, Brandt, S, Lodge, D, Bortolotto, Z A & Adejare, A 2019, ' Pharmacological characterizations of the 'legal high' fluorolintane and isomers ', European Journal of Pharmacology, vol. 857, 172427 . https://doi.org/10.1016/j.ejphar.2019.172427
Eur J Pharmacol
Eur J Pharmacol
1,2-Diarylethylamines represent a class of molecules that have shown potential in the treatment of pain, epilepsy, neurodegenerative disease and depression. Examples include lefetamine, remacemide, and lanicemine. Recently, several 1,2-diarylethylami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354c330c5dc3f8907040764dc6edf15a
https://doi.org/10.1016/j.ejphar.2019.172427
https://doi.org/10.1016/j.ejphar.2019.172427
Autor:
M.A Lee, Donald F. Weaver, N. Pillay, Warren T. Blume, A. Guberman, T.A.H Holdich, F. Veloso, M. W. Jones
Publikováno v:
Seizure. 11:104-113
Remacemide hydrochloride is a low-affinity, non-competitive NMDA receptor channel blocker under investigation for the treatment of epilepsy. This double-blind, placebo-controlled, multicentre study assessed the safety and efficacy of adjunctive remac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024a49dae4a3d4d00e4d0c9b5c09a03e
https://doi.org/10.1053/seiz.2002.0589
https://doi.org/10.1053/seiz.2002.0589
Publikováno v:
Seizure. 9(8):537-543
The efficacy, safety and pharmacokinetics of adjunctive remacemide hydrochloride, a novel, low-affinity non-competitive NMDA receptor channel blocker, were investigated in 28 adult patients with refractory epilepsy. This was a randomized double-blind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aca4e142c477fbd600e9129b87ba3cb
Akademický článek
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Autor:
Kevin M. Biglan, Radu Constantinescu, Bernard Ravina, Megan M. Romer, Karl Kieburtz, Alicia Brocht, Michael P. McDermott, Ira Shoulson
Publikováno v:
Movement Disorders. 23:1223-1227
The objective of this study was to examine the relationship between CAG repeat length (CAGn) and clinical progression in patients with Huntington's disease (HD). There are conflicting reports about the relationship between CAGn and clinical progressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65088e65e73841d3aed1ece48efbdeae
https://doi.org/10.1002/mds.21988
https://doi.org/10.1002/mds.21988
Publikováno v:
Neurotoxicology and Teratology. 29:348-359
The effects of chronic exposure to ketamine or remacemide on the acquisition and performance of food-reinforced operant behaviors was assessed in female Sprague-Dawley rats. Ketamine is an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7311242c16e9bd2d4e8d75871e7c875
https://doi.org/10.1016/j.ntt.2006.12.004
https://doi.org/10.1016/j.ntt.2006.12.004
Akademický článek
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Autor:
Gareth R. Lewis, Gerry Steele, Lorraine McBride, Alastair J. Florence, Alan R. Kennedy, Norman Shankland, William I. F. David, Kenneth Shankland, Simon J. Teat
Publikováno v:
Crystal Growth & Design. 5:427-438
Remacemide [2-amino-N-(1-methyl-1,2-diphenylethyl)-acetamide] was developed as a potential antagonist for epilepsy, Parkinsonism, and Huntington's disease. This paper investigates hydrophilic and hydrophobic intermolecular interactions that occur wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f055155f24007b40fc45752ce41d2c
https://doi.org/10.1021/cg049836u
https://doi.org/10.1021/cg049836u