Výsledky vyhledávání

Complement component C1q is produced by isolated articular chondrocytes

Autor: J.C. Kwekkeboom, R.A. van Schaarenburg, R. Mahdad, Rik Lories, Andreea Ioan-Facsinay, A Bakker, Silvia Monteagudo, Chahrazad Cherifi, R. Lubbers, Rem Toes, E W N Levarht, Leendert A. Trouw

Publikováno v: Osteoarthritis and Cartilage
Osteoarthritis and Cartilage, 28(5), 675-684. ELSEVIER SCI LTD

OBJECTIVE: Inflammation and innate immune responses may contribute to development and progression of Osteoarthritis (OA). Chondrocytes are the sole cell type of the articular cartilage and produce extracellular-matrix molecules. How inflammatory medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efa5667e20d85e945cbf3ea0be20560
https://doi.org/10.1016/j.joca.2019.09.007

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Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications

Autor: M. Reth, E W N Levarht, Hans Scherer, J.C. Kwekkeboom, J. W. Drijfhout, Holger Bang, Sanne Reijm, Gerrie Stoeken-Rijsbergen, Arieke S. B. Kampstra, George M.C. Janssen, P.A. van Veelen, Marco Cavallari, Corrie M. Wortel, Rem Toes, Twj Huizinga, Theresa Kissel, Rochelle D Vergroesen, Kimberly M. Bonger, Linda M. Slot

Publikováno v: Annals of the rheumatic diseases, 79(4):216499, 472-480. BMJ Publishing Group
Annals of the Rheumatic Diseases, 79, 472-480
Annals of the Rheumatic Diseases, 79, 4, pp. 472-480
Annals of the Rheumatic Diseases, 79(4), 472-480. BMJ PUBLISHING GROUP
Annals of the rheumatic disease

ObjectiveAutoantibodies against antigens carrying distinct post-translational modifications (PTMs), such as citrulline, homocitrulline or acetyllysine, are hallmarks of rheumatoid arthritis (RA). The relation between these anti-modified protein antib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88893b425b91fa2311059af461e13bb1
https://doi.org/10.1136/annrheumdis-2019-216499

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ACPA-IgG variable domain glycosylation increases before the onset of rheumatoid arthritis and stabilizes thereafter; a cross-sectional study encompassing over 1500 samples

Autor: Cornelia F Allaart, L. Hafkenscheid, Solbritt Rantapää-Dahlqvist, Hani El-Gabalawy, S.-Y. Kawashiri, Twj Huizinga, Mami Tamai, Rem Toes, Theresa Kissel, D. van Schaardenburg, Hans Scherer, A. Kawakami, Manfred Wuhrer, T.J. Wesemael, D. van der Woude, A.H.M. van der Helm-van Mil

ObjectiveThe autoimmune response in rheumatoid arthritis (RA) is marked by anti-citrullinated protein antibodies (ACPA). A remarkable feature of ACPA-IgG is the abundant expression of N-linked glycans in the variable domain. Nonetheless, the presence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5f4642a310065f6dbb2175faff1b801
https://doi.org/10.1101/2021.11.05.467407

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Immunoprofiling of early, untreated rheumatoid arthritis using mass cytometry reveals an activated basophil subset inversely linked to ACPA status

Autor: Marjolijn Hameetman, J.C. Kwekkeboom, Vincent van Unen, A.H.M. van der Helm-van Mil, Guillaume Beyrend, F. A. van Gaalen, Rem Toes, Hester Koppejan

Publikováno v: Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021)
Arthritis Research and Therapy, 23(1). BMC

Background Autoantibody production is a hallmark of rheumatoid arthritis (RA). Anti-citrullinated protein antibodies (ACPA) are highly disease-specific, and their presence is associated with more severe disease and poor prognosis compared to ACPA-neg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ea73d0021e2ca9456256af6ef985e0
http://europepmc.org/articles/PMC8555233

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POS0384 A NOVEL MECHANISM LINKING MUCOSAL BACTERIA WITH AUTOANTIBODY RESPONSES IN RA: ACETYLATED BACTERIAL LYSATE AS A MODEL ANTIGEN

Autor: J.C. Kwekkeboom, Rem Toes, M. Volkov, Arieke S. B. Kampstra, Twj Huizinga, D. van der Woude, K. van Schie

Publikováno v: Annals of the Rheumatic Diseases. 80:422.1-422

Background:Rheumatoid arthritis (RA) is characterized by autoantibodies against post-translationally modified proteins (AMPA) such as citrullinated, carbamylated and acetylated proteins. Importantly, these antibodies are highly multireactive, as they

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9fe6c844ef2c0494c4e213db2b1d6c5
https://doi.org/10.1136/annrheumdis-2021-eular.1709

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POS0395 ANTI-ACETYLATED PROTEIN ANTIBODIES IN RHEUMATOID ARTHRITIS (RA): CLUES FOR THE STARTING POINT OF AUTOANTIBODY RESPONSES IN RA

Autor: A. Van der Helm van Mil, Twj Huizinga, Annemarie L. Dorjée, D. van der Woude, Rem Toes, T. van Wesemael

Publikováno v: Annals of the Rheumatic Diseases. 80:426.3-427

Background:Rheumatoid arthritis (RA) is characterized by autoantibodies such as rheumatoid factor (RF) and anti-modified protein autoantibodies (AMPAs) like anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein antibodies (anti-C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25bd44cfb00ad7a1bb0f73646c8f8564
https://doi.org/10.1136/annrheumdis-2021-eular.2777

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AB0022 AUTOREACTIVE B CELLS IN RHEUMATOID ARTHRITIS DISPLAY AN ACTIVATED PHENOTYPE OF RECENT ANTIGEN EXPOSURE

Autor: Hans Scherer, N. Blomberg, Rem Toes, Twj Huizinga, Hendy Kristyanto

Publikováno v: Annals of the Rheumatic Diseases. 80:1045.1-1045

Background:Rheumatoid arthritis, in particular ACPA+ RA, is characterized by frequent disease flares and poor chances to achieve DMARD-free sustained remission. Recently, we have shown that ACPA-expressing memory B cells (MBC) remain in a persistentl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08d182e0d70ddd254bf4d445b5ad950f
https://doi.org/10.1136/annrheumdis-2021-eular.2050

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