Zobrazeno 1 - 10
of 1 408
pro vyhledávání: '"Relative potency"'
Autor:
Aafke W. F. Janssen, Wendy Jansen Holleboom, Deborah Rijkers, Jochem Louisse, Sjoerdtje A. Hoekstra, Sanne Schild, Misha F. Vrolijk, Ron L. A. P. Hoogenboom, Karsten Beekmann
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Exposure to PFASs is associated to several adverse health effects, such as immunotoxicity. Immunotoxic effects of PFOA and PFOS, including a reduced antibody response in both experimental animals and humans, have been reported. However, there is limi
Externí odkaz:
https://doaj.org/article/1fdaed18e8dc44ae98f85dd2c4aeab56
Publikováno v:
环境与职业医学, Vol 40, Iss 6, Pp 655-660 (2023)
BackgroundNeonicotinoid insecticides (NEOs) are emerging synthetic insecticides that have been used in various pest management regimens worldwide as alternatives to conventional insecticides. Recently, several studies have indicated that humans are w
Externí odkaz:
https://doaj.org/article/ffd5bdc5c5294cd9b34343b79f2add8b
Autor:
Yasser Alhejji, Frances Widjaja, Shenghan Tian, Thomas Hoekstra, Sebastiaan Wesseling, Ivonne M.C.M. Rietjens
Publikováno v:
Current Research in Toxicology, Vol 6, Iss , Pp 100160- (2024)
Pyrrolizidine alkaloids (PAs) and their N-oxides (PA-N-oxides) are phytotoxins found in food, feed and the environment. Yet, limited data exist from which the relative potency of a PA-N-oxide relative to its corresponding PA (REPPANO to PA) can be de
Externí odkaz:
https://doaj.org/article/0a1d0db4a07c49ab9fa0891ca038371f
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Over 1,000 pyrrolizidine alkaloids (PAs) and their N-oxides (PA-N-oxides) occur in 3% of all flowering plants. PA-N-oxides are toxic when reduced to their parent PAs, which are bioactivated into pyrrole intermediates that generate protein- and DNA-ad
Externí odkaz:
https://doaj.org/article/63f7fb95d1a64398938a6ffc22f9263f
Autor:
Wieneke Bil, Veronika Ehrlich, Guangchao Chen, Rob Vandebriel, Marco Zeilmaker, Mirjam Luijten, Maria Uhl, Philip Marx-Stoelting, Thorhallur Ingi Halldorsson, Bas Bokkers
Publikováno v:
Environment International, Vol 171, Iss , Pp 107727- (2023)
Relative potency factors (RPFs) for per- and polyfluoroalkyl substances (PFAS) have previously been derived based on liver effects in rodents for the purpose of performing mixture risk assessment with primary input from biomonitoring studies. However
Externí odkaz:
https://doaj.org/article/e60c8f3566544d83be6054136506e11c
Autor:
Justin M. Conley, Christy S. Lambright, Nicola Evans, Elizabeth Medlock-Kakaley, Aaron Dixon, Donna Hill, James McCord, Mark J. Strynar, Jermaine Ford, L. Earl Gray, Jr.
Publikováno v:
Environment International, Vol 170, Iss , Pp 107631- (2022)
Globally, biomonitoring data demonstrate virtually all humans carry residues of multiple per- and polyfluoroalkyl substances (PFAS). Despite pervasive co-exposure, limited mixtures-based in vivo PFAS toxicity research has been conducted. Perfluorooct
Externí odkaz:
https://doaj.org/article/de1c98457cf04d04943d6a4c23844156
Autor:
Kei Nakayama, Nguyen Minh Tue, Naoto Fujioka, Hideaki Tokusumi, Akitoshi Goto, Naoto Uramaru, Go Suzuki
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 247, Iss , Pp 114227- (2022)
World Health Organization toxic equivalency factors (WHO-TEFs) are recommended for risk management of brominated dioxins in aquatic environments because limited information is available on their toxicity to fish. To validate this approach, we obtaine
Externí odkaz:
https://doaj.org/article/62cdb810649b4f919d8e42c040d45059
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 245, Iss , Pp 114091- (2022)
Due to the wide existence of neonicotinoid insecticides (neonics) and their potential impact on ecosystems and human health, they have received special attention in recent years. Soil is not only a sink of neonics but also a source of neonics, so it
Externí odkaz:
https://doaj.org/article/24237896439c4037a396cba91b65a525
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