A tissue-specific promoter derived from a SINE retrotransposon drives biallelic expression of PLAGL1 in human lymphocytes.

Autor: Claire E L Smith, Alexia Alexandraki, Sarah F Cordery, Rekha Parmar, David T Bonthron, Elizabeth M A Valleley

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0185678 (2017)

The imprinted gene PLAGL1 is an important regulator of apoptosis and cell cycle arrest. Loss of its expression has been implicated in tumorigenesis in a range of different cancers, and overexpression during fetal development causes transient neonatal

Externí odkaz: https://doaj.org/article/4c5efe9de045428f9b2d5783e8b068b0

T-cell subset abnormalities predict progression along the Inflammatory Arthritis disease continuum: implications for management

Autor: Hanna Gul, Agata Burska, Rekha Parmar, Thibault Rabin, Maya H Buch, Frederique Ponchel, L. Hunt, Philip G. Conaghan, Paul Emery

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)

The presence of a disease continuum in inflammatory arthritis (IA) is a recognised concept, with distinct stages from at-risk stage (presence of anti citrullinated-peptide autoantibody) to diagnosis of rheumatoid arthritis (RA), including therapy-ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f524f8afc57682a88c5c8950d3eec601
https://doi.org/10.1038/s41598-020-60314-w

Defining remission in rheumatoid arthritis: does it matter to the patient? A comparison of multi-dimensional remission criteria and patient reported outcomes

Autor: Jianhua Wu, Gisella Eugenio, Frederique Ponchel, Thibault Rabin, Agata Burska, Hanna L Gul, Rekha Parmar, Paul Emery

Publikováno v: Rheumatology (Oxford, England). 59(3)

Objectives In a cross-sectional study, we evaluated the prevalence of ‘multi-dimensional remission’ (MDR) and its component parameters, assessed using objective measures in a cohort of RA patients in treatment-induced DAS28-remission, and their r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdfa40f4a06cb4ad8c44e98e557ec30
https://pubmed.ncbi.nlm.nih.gov/31424522

Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data

Autor: A. Gilmour, S Schwank, Frederic Geissmann, Christopher M Mela, B Kola, B Harvey, I Vranic, Evan Tzanis, H-D Zucht, Peter C. Taylor, J Diboll, Alexandra Belson, G Molyneux, MA Sleeman, Rekha Parmar, E Vernon, Stephen P. Young, Iona Donnelly, C Cuff, P Schulz-Knappe, Heidi Lempp, Christopher D. Buckley, N Payne, John D. Isaacs, Coziana Ciurtin, H Noble, M Macoritto, A Parke, S Jelinsky, James N. Galloway, Ian C. Scott, Frederique Ponchel, Sarah Keidel, Denny Verbeeck, A Didierlaurent, MF McDermot, J Tarn, AT Virlan, T Lazarov, J Ellis, S Kaymakcalan, Anthony Rowe, Catharien M. U. Hilkens, G Altobelli, M Loza, P Jones, Ayako Wakatsuki Pedersen, Ian N. Bruce, Duncan Porter, A Cuza, D Ziemek, S Talbot, C Marshall, A Herath, D Finch, D Baker, Maya H Buch, Y Zhong, R Toward, Ludbrook, Mark Coles, Barnes, M Ho, M Page, J Casement, M Maciejewski, Claudio Carini, Sarah Brockbank, D Nguyen, H Tipney, A Filer, Christopher R. John, S Kelly, Andrew P. Cope, W Burny, M Curran, Catharina Lindholm, Benjamin A Fisher, Ray Harris, Jehan J. El-Jawhari, P Stocks, D Dastros-Pitel, Z Liu, Bdm Tom, Dennis Lendrem, Wayne Tsuji, F Stirling, J Worthington, Deborah P M Symmons, Matthew A. Sleeman, D Padhji, Fowzia Ibrahim, Smm Verstappen, P Budde, Ehrenstein, Marc C. Levesque, R Harry, B Allen, T Sabin, Michael Binks, Sally Hollis, Gerry Parker, S Lipsky, Georgina Thorborn, M Jenkins, A Hughes-Morley, Costantino Pitzalis, N Joseph, H Edwards, Jamie C. Sergeant, Paul Emery, H Ali, JA Butler, Liliane Fossati-Jimack, S Wright, Fiona Clarke, W Wu, Amy E. Anderson, Sharmila Rana, F Humby, F Hong, Myles Lewis, A Haynes, Katriona Goldmann, S Martins, CT Mela, S Hasan, David Scott, L Rowell, David Watson, Neil Gozzard, Karim Raza, Simon Read, M Hodge, Carl S. Goodyear, Farewell, George Davey Smith, Michele Bombardieri, Iain B. McInnes, C Larminie, G Simpson, N Ward, K Hicks, R Rao, Z Jia, FB Capdevila, A Long

Publikováno v: RA-MAP Consortium, Tom, B & Symmons, D 2018, ' Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data ', RMD Open, vol. 4, no. 2, pp. e000721 . https://doi.org/10.1136/rmdopen-2018-000721
RMD Open

ObjectivesTo identify predictors of remission and disease activity patterns in patients with rheumatoid arthritis (RA) using individual participant data (IPD) from clinical trials.MethodsPhase II and III clinical trials completed between 2002 and 201

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b48a096d68180fc5745f1e771c2710f
https://doi.org/10.1136/rmdopen-2018-000721

Efficacy of Cinnamomum Zeylanicum and Cinnamomum Tamala in the Management of Hypercholesterolemia

Autor: Rekha Parmar, Yogita Tilavat

Publikováno v: Journal of Ayurveda and Integrated Medical Sciences (JAIMS). 2

In Modern medicine, Hypercholesterolemia is under dyslipidemia. It is the presence of high cholesterol level in the blood. Now days, Hypercholesterolemia is a dangerous problem among the people. To know the effectiveness of Cinnamomum zeylanicum and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2a2ce5f2e5e5b3fd06c369c3984dc0f
https://doi.org/10.21760/jaims.v2i2.7705