Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Rekha Iyengar"'
Autor:
Rekha Iyengar, Mondira Kundu, Junmin Peng, Lu Xu, Fusun Kilic, Xiu Jie Li-Harms, Tullia Lindsten, Anjon Audhya, Linda M. Hendershot, Douglas R. Green, Ji Ying Sze, Christopher Wright, Bo Wang, Timothy I. Shaw, E.B. Frankel, Joung Hyuck Joo, Liang Ge
Publikováno v:
Molecular Cell. 62:491-506
ULK1 and ULK2 are thought to be essential for initiating autophagy, and Ulk1/2-deficient mice die perinatally of autophagy-related defects. Therefore, we used a conditional knockout approach to investigate the roles of ULK1/2 in the brain. Although t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb474edbbc73e060af000ed2eadf04a
https://doi.org/10.1016/j.molcel.2016.04.020
https://doi.org/10.1016/j.molcel.2016.04.020
Autor:
Mao Yang, Alfonso Lavado, Xinwei Cao, Bo Wang, Rekha Iyengar, Linda Horner, Joung Hyuck Joo, Xiujie Li-Harms, Douglas R. Green, Jun-Lin Guan, Sharon Frase, Christopher Wright, Mondira Kundu
Mammalian ULK1 (unc-51 like kinase 1) and ULK2, Caenorhabditis elegans UNC-51, and Drosophila melanogaster Atg1 are serine/threonine kinases that regulate flux through the autophagy pathway in response to various types of cellular stress. C. elegans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0573e1342b5a68c18233ee27767b08
https://europepmc.org/articles/PMC6070005/
https://europepmc.org/articles/PMC6070005/
Autor:
John D. Schuetz, John P. Lynch, Tomas A. Prolla, Rekha Iyengar, Xiujie Li-Harms, Mondira Kundu, Yong-Dong Wang, Christopher M. Wright, Geoffrey Neale, Aashish Joshi, Joseph T. Opferman, Xi Wang, James E. Thompson, Sandra Milasta, Douglas R. Green
Publikováno v:
Blood. 125:162-174
Somatic mitochondrial DNA (mtDNA) mutations contribute to the pathogenesis of age-related disorders, including myelodysplastic syndromes (MDS). The accumulation of mitochondria harboring mtDNA mutations in patients with these disorders suggests a fai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b8fe0bead2ea42e54e3c1b4e918e8c
https://doi.org/10.1182/blood-2014-07-586396
https://doi.org/10.1182/blood-2014-07-586396
Autor:
Yevgeniya E. Koshman, Brenda Russell, Rekha Iyengar, Taehoon Kim, Jody L. Martin, Miensheng Chu, Allen M. Samarel, Alain Heroux, Seth L. Robia
Publikováno v:
Cardiovascular Research. 92:409-419
Aims Tyrosine-phosphorylated focal adhesion kinase (FAK) is required for the hypertrophic response of cardiomyocytes to growth factors and mechanical load, but the role of FAK serine phosphorylation in this process is unknown. The aims of the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5524d9c2255d455b63b4823a86e211
https://doi.org/10.1093/cvr/cvr247
https://doi.org/10.1093/cvr/cvr247
Autor:
Kristie L. Rose, Der-Fen Suen, Ji Zhang, Mondira Kundu, Do Hyung Kim, Frank C. Dorsey, Chang Hwa Jung, Stephanie M. Prater, Joung Hyuck Joo, Kristin M. Hennessy-Walters, Meredith A. Steeves, Rekha Iyengar, John L. Cleveland, Craig B. Thompson, Kelly McCastlain, Chia Ying Yang, Richard J. Youle, Paul A. Ney, Aashish Joshi
Publikováno v:
Molecular Cell. 43(4):572-585
Autophagy, the primary recycling pathway of cells, plays a critical role in mitochondrial quality control under normal growth conditions and in the response to cellular stress. The Hsp90-Cdc37 chaperone complex coordinately regulates the activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c4d3e39a2f8ba4534ec4923f045eba
Autor:
Yevgeniya E. Koshman, Rekha Iyengar, Steven J. Engman, Allen M. Samarel, Seth L. Robia, Taehoon Kim, Miensheng Chu
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 30:2226-2233
Objective— To examine whether interference with FRNK targeting to focal adhesions (FAs) affects its inhibitory activity and tyrosine phosphorylation. Methods and Results— Focal adhesion kinase and its autonomously expressed C-terminal inhibitor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955f9d9b65d20929470a903076cfb8fd
https://doi.org/10.1161/atvbaha.110.212761
https://doi.org/10.1161/atvbaha.110.212761
Autor:
Amber L. Ward, Saghi Ghaffari, Rekha Iyengar, Xiujie Li-Harms, Joung Hyuck Joo, Christopher Wright, Aashish Joshi, Queenie Vong, Mondira Kundu, Phillip W. Hargrove
Publikováno v:
Experimental Hematology. 64:S110
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62b19d077c11c9df253aff40248b5d4a
https://doi.org/10.1016/j.exphem.2018.06.174
https://doi.org/10.1016/j.exphem.2018.06.174
Autor:
Geoffrey Neale, Fred G. Behm, David Finkelstein, Wing Leung, Rekha Iyengar, Michael B. Kastan, Ching-Hon Pui
Publikováno v:
Cancer Epidemiology. 34:303-308
Background : Survivors of childhood acute lymphoblastic leukemia (ALL) are at an increased risk of developing secondary malignant neoplasms. Radiation and chemotherapy can cause mutations and cytogenetic abnormalities and induce genomic instability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac0213c75bf7d0926717f47414b5474
https://doi.org/10.1016/j.canep.2010.03.008
https://doi.org/10.1016/j.canep.2010.03.008
Autor:
Kyle K. Henderson, Steven J. Engman, Yevgeniya E. Koshman, Taehoon Kim, Allen M. Samarel, Rekha Iyengar
Publikováno v:
Cardiovascular Research. 85:571-581
Aims Focal adhesion kinase (FAK) and its autonomously expressed, C-terminal inhibitor FAK-related non-kinase (FRNK), are important regulators of vascular smooth muscle cell (VSMC) spreading and migration. However, the mechanisms of FRNK-mediated inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad6362b32f697b982a19666b4574569
https://doi.org/10.1093/cvr/cvp322
https://doi.org/10.1093/cvr/cvp322
Autor:
Rekha Iyengar, Marti S. Holladay, Kwan Gan, Wing Leung, Victoria Turner, Brandon M. Triplett, Frederick G. Behm, Edwin M. Horwitz
Publikováno v:
Leukemia. 23:1278-1287
Inhibitory NK cell receptors are recognized as important determinants of NK cell activity in hematopoietic cell transplantation (HCT). The role of activating receptors and their acquisition after HCT is less certain. Therefore, we comprehensively eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de787ec426fb643144bd6df33e6a5ed9
https://doi.org/10.1038/leu.2009.21
https://doi.org/10.1038/leu.2009.21