Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Rekha G Panchal"'
Autor:
Erkan Kiris, Jonathan E Nuss, Stephanie M Stanford, Laura M Wanner, Lisa Cazares, Michael F Maestre, Hao T Du, Glenn Y Gomba, James C Burnett, Rick Gussio, Nunzio Bottini, Rekha G Panchal, Christopher D Kane, Lino Tessarollo, Sina Bavari
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129264 (2015)
There is an urgent need to develop novel treatments to counter Botulinum neurotoxin (BoNT) poisoning. Currently, the majority of BoNT drug development efforts focus on directly inhibiting the proteolytic components of BoNT, i.e. light chains (LC). Al
Externí odkaz:
https://doaj.org/article/60298f029db949189b12f9558abf609f
Autor:
Felicia D Langel, Chih-Yuan Chiang, Douglas Lane, Tara Kenny, Jenifer F Ojeda, Yang Zhong, Jianwei Che, Yingyao Zhou, Wilson Ribot, Krishna P Kota, Sina Bavari, Rekha G Panchal
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87201 (2014)
Alveolar macrophages (AMs) phagocytose Bacillus anthracis following inhalation and induce the production of pro-inflammatory cytokines and chemokines to mediate the activation of innate immunity. Ames, the virulent strain of B. anthracis, contains tw
Externí odkaz:
https://doaj.org/article/41579968887f4aceb1ffbdfacac54d16
Autor:
Krishna P Kota, Brett Eaton, Douglas Lane, Melanie Ulrich, Ricky Ulrich, Brian D Peyser, Camenzind G Robinson, James G Jaissle, Gianluca Pegoraro, Sina Bavari, Rekha G Panchal
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55167 (2013)
The molecular machinery that regulates the entry and survival of Yersinia pestis in host macrophages is poorly understood. Here, we report the development of automated high-content imaging assays to quantitate the internalization of virulent Y. pesti
Externí odkaz:
https://doaj.org/article/15728c4af58a4e93b1a9471e1e51631f
Autor:
Peter B Madrid, Sidharth Chopra, Ian D Manger, Lynne Gilfillan, Tiffany R Keepers, Amy C Shurtleff, Carol E Green, Lalitha V Iyer, Holli Hutcheson Dilks, Robert A Davey, Andrey A Kolokoltsov, Ricardo Carrion, Jean L Patterson, Sina Bavari, Rekha G Panchal, Travis K Warren, Jay B Wells, Walter H Moos, Raelyn L Burke, Mary J Tanga
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60579 (2013)
BACKGROUND: The rapid development of effective medical countermeasures against potential biological threat agents is vital. Repurposing existing drugs that may have unanticipated activities as potential countermeasures is one way to meet this importa
Externí odkaz:
https://doaj.org/article/8f664db31ceb45f1adcae9b7d13042df
Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease
Autor:
Rajini R. Mudhasani, Joseph W. Golden, Gregory C. Adam, Timothy J. Hartingh, Krishna P. Kota, David Ordonez, Corey R. Quackenbush, Julie P. Tran, Curtis Cline, Janice A. Williams, Xiankun Zeng, David B. Olsen, Linda A. Lieberman, Christopher Boyce, Anthony Ginnetti, J. Matthew Meinig, Rekha G. Panchal, Eric M. Mucker
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTAlthough smallpox has been eradicated, other orthopoxviruses continue to be a public health concern as exemplified by the ongoing Mpox (formerly monkeypox) global outbreak. While medical countermeasures (MCMs) previously approved by the Food
Externí odkaz:
https://doaj.org/article/53df8f67d29d4344baea9e9e6311d3a1
Autor:
Chih-Yuan Chiang, Douglas J. Lane, Yefen Zou, Tim Hoffman, Jianfeng Pan, Janice Hampton, Jillian Maginnis, Bishnu P. Nayak, Ugo D’Oro, Nicholas Valiante, Andrew T. Miller, Michael Cooke, Tom Wu, Sina Bavari, Rekha G. Panchal
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Current therapies for anthrax include the use of antibiotics (i.e., doxycycline, and ciprofloxacin), an anthrax vaccine (BioThrax) and Bacillus anthracis-specific, monoclonal antibody (mAb) (i.e., Raxibacumab and obiltoxaximab). In this study, we inv
Externí odkaz:
https://doaj.org/article/3ab3d25f2f914680b584dec5a98275c9
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Botulinum neurotoxins (BoNTs) are known as the most potent bacterial toxins, which can cause potentially deadly disease botulism. BoNT Serotype A (BoNT/A) is the most studied serotype as it is responsible for most human botulism cases, and its formul
Externí odkaz:
https://doaj.org/article/5976d6960ae14abe8977a4ec18ca95bf
Autor:
Chih-Yuan Chiang, Yang Zhong, Michael D. Ward, Douglas J. Lane, Tara Kenny, Raysa Rosario-Acevedo, Brett P. Eaton, Sylvia R. Treviño, Taylor B. Chance, Meghan Hu, Patricia L. Worsham, David M. Waag, Richard T. Moore, Lisa H. Cazares, Christopher K. Cote, Yingyao Zhou, Rekha G. Panchal
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Burkholderia mallei, the causative agent of glanders, is a gram-negative intracellular bacterium. Depending on different routes of infection, the disease is manifested by pneumonia, septicemia, and chronic infections of the skin. B. mallei poses a se
Externí odkaz:
https://doaj.org/article/a5849fdd7dd94dffa5ef5fe2d6505e13
Autor:
Chih-Yuan Chiang, Ijeoma Uzoma, Richard T. Moore, Merle Gilbert, Allen J. Duplantier, Rekha G. Panchal
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
ABSTRACT Increasing incidences of multidrug resistance in pathogenic bacteria threaten our ability to treat and manage bacterial infection. The development and FDA approval of novel antibiotics have slowed over the past decade; therefore, the adoptio
Externí odkaz:
https://doaj.org/article/7de0eec81d1e40dc8ff6383e4cf2aa95
Autor:
Donald Biek, Stephanie Halasohoris, Jennifer M. Scarff, Brendan Hannah, Sanae Lembirik, Rekha G. Panchal, Steven D. Zumbrun, Lisa M. Pysz, Margaret M. Lemmon
Publikováno v:
The Journal of Antibiotics
Antimicrobial-resistance (AMR) has become an increasingly difficult issue to overcome for bacteria associated with both community- and hospital-acquired infections as well as potential biodefense threats. The need to identify new therapeutics of nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49c501414275c58f71f82ace2c522b7
https://doi.org/10.1038/s41429-021-00472-9
https://doi.org/10.1038/s41429-021-00472-9