Výsledky vyhledávání - "Rekha Chakravarty"

Cell-intrinsic programmed death ligand-1 (PD-L1) inhibits cytotoxic chemo, promotes DNA damage repair, and enhances ATM/ATR signaling following exposure to DNA damaging agents in bladder, melanoma, and ovarian cancer cells

Autor: Anand V Kornepati, Deyi Zhang, Heather G. Hambright, Suresh C. Kari, Yilun Deng, Curtis A. Clark, Harshita B. Gupta, Rekha Chakravarty, Yanfen Hu, Rong Li, Tyler J. Curiel

Publikováno v: The Journal of Immunology. 202:195.17-195.17

We have shown that cancer cell-intrinsic PD-L1 signals increase mTORC1 and unbundle actin. To test if tumor cell PD-L1 affects the DNA damage response (DDR) we made PD-L1KO mouse ID8agg (ovarian) and B16 (melanoma), and human bladder RT4 cancer lines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::312c4213c560f26480e00871be5713a2
https://doi.org/10.4049/jimmunol.202.supp.195.17

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