Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Rekha Bassi"'
Autor:
Gian F, De Nicola, Rekha, Bassi, Charlie, Nichols, Mariana, Fernandez-Caggiano, Pelin Arabacilar, Golforoush, Dibesh, Thapa, Rhys, Anderson, Eva Denise, Martin, Sharwari, Verma, Jens, Kleinjung, Adam, Laing, Jonathan P, Hutchinson, Philip, Eaton, James, Clark, Michael S, Marber
Publikováno v:
JCI insight. 3(16)
Inhibiting MAPK14 (p38α) diminishes cardiac damage in myocardial ischemia. During myocardial ischemia, p38α interacts with TAB1, a scaffold protein, which promotes p38α autoactivation; active p38α (pp38α) then transphosphorylates TAB1. Previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e605d5f2e83ad8d47b505f93acf97da5
https://pubmed.ncbi.nlm.nih.gov/30135318
https://pubmed.ncbi.nlm.nih.gov/30135318
Autor:
Dibesh, Thapa, Charlie, Nichols, Rekha, Bassi, Eva Denise, Martin, Sharwari, Verma, Maria R, Conte, Vittorio, De Santis, Gian F, De Nicola, Michael S, Marber
Publikováno v:
Molecular and Cellular Biology
p38α mitogen-activated protein kinase is essential to cellular homeostasis. Two principal mechanisms to activate p38α exist. The first relies on dedicated dual-specificity kinases such as mitogen-activated protein kinase kinase (MAP2K) 3 (MKK3) or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::416907eb8e317fbe049ab366a93e33b5
https://pubmed.ncbi.nlm.nih.gov/29229647
https://pubmed.ncbi.nlm.nih.gov/29229647
Publikováno v:
British Journal of Pharmacology. 172:2101-2113
PKs transfer a phosphate from ATP to the side-chain hydroxyl group of a serine, threonine or tyrosine residue of a substrate protein. This in turn can alter that protein's function; modulating fundamental cellular processes including, metabolism, tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bcad6d495eb82c864d7fa00addfd513
https://doi.org/10.1111/bph.12901
https://doi.org/10.1111/bph.12901
Autor:
Gian Felice De Nicola, Stefan Knapp, Luigi Martino, James Clark, Eva Denise Martin, Rekha Bassi, R. Andrew Atkinson, Michael S. Marber, Apirat Chaikuad, Renée Tata, Sharwari Verma, Maria R. Conte, Pierre Sicard
Publikováno v:
Nature structural & molecular biology
Nature Structural & Molecular Biology; Vol 20
Nature Structural & Molecular Biology; Vol 20
p38α mitogen-activated protein kinase (p38α) is activated by a variety of mechanisms, including autophosphorylation initiated by TGFβ-activated kinase 1 binding protein 1 (TAB1) during myocardial ischemia and other stresses. Chemical-genetic appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4622da0ae6322d885d0541017cbaeea
https://doi.org/10.1038/nsmb.2668
https://doi.org/10.1038/nsmb.2668
Autor:
Rhys Anderson, E V Martin, Rekha Bassi, Charles J. Nichols, James Clark, Dibesh Thapa, G F De Nicola, M Caggiano Fernandez, Michael S. Marber
Publikováno v:
Cardiovascular Research. 114:S15-S15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da95427a0f6725e3bf271cb9a6370f00
https://doi.org/10.1093/cvr/cvy060.025
https://doi.org/10.1093/cvr/cvy060.025
Autor:
James Clark, Sebastien Jacquet, Rekha Bassi, Michael S. Marber, Sarawut Kumphune, Stephen J. O'Keefe, Sharwari Verma, Pierre Sicard, Metin Avkiran
Publikováno v:
Journal of Biological Chemistry. 285:2968-2975
The use of nonselective pharmacological inhibitors has resulted in controversy regarding the mechanism and consequences of p38 activation during myocardial infarction. Classic p38 inhibitors such as SB203580 rely on a critical "gatekeeper" threonine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36c36cce67e023a16f5587e356a5e54
https://doi.org/10.1074/jbc.m109.079228
https://doi.org/10.1074/jbc.m109.079228
Autor:
Vittorio Calabrese, James Clark, Roberta Foresti, Roberto Motterlini, Rekha Bassi, Colin J. Green
Publikováno v:
Journal of Biological Chemistry. 275:13613-13620
The stress protein heme oxygenase-1 (HO-1) is induced in endothelial cells exposed to nitric oxide (NO)-releasing agents, and this process is finely modulated by thiols (Foresti, R., Clark, J. E., Green, C. J., and Motterlini R. (1997) J. Biol. Chem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdc84db23748e82b0651464223d05666
https://doi.org/10.1074/jbc.275.18.13613
https://doi.org/10.1074/jbc.275.18.13613
Publikováno v:
Free Radical Biology and Medicine. 28:1303-1312
Curcumin, a widely used spice and coloring agent in food, has been shown to possess potent antioxidant, antitumor promoting and anti-inflammatory properties in vitro and in vivo. The mechanism(s) of such pleiotropic action by this yellow pigment is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1512670d28effa5a266dcbc9aa8802ef
https://doi.org/10.1016/s0891-5849(00)00294-x
https://doi.org/10.1016/s0891-5849(00)00294-x
Autor:
Gian Felice De Nicola, E D Martin, Rekha Bassi, Sharwari Verma, Maria Conte, Michael S Marber
Publikováno v:
Circulation Research. 111
Activation of p38α MAPK (p38α), by phosphorylation of two residues in the TGY motif of the activation loop, can occur independently of upstream kinases. One such mechanism involves the scaffolding protein Transforming Growth Factor-β-activated pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a57191deb4936ee86298035269c74b1e
https://doi.org/10.1161/res.111.suppl_1.a32
https://doi.org/10.1161/res.111.suppl_1.a32
Publikováno v:
Circulation Research. 111
The p38 mitogen-activated protein kinase (MAPK) family has been implicated in many aspects of cell biology including inflammation, gene expression, cell cycle progression, differentiation and apoptosis. The canonical pathway of p38 activation results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::160f0ee4eaf174256368dd0ea6f62aa6
https://doi.org/10.1161/res.111.suppl_1.a336
https://doi.org/10.1161/res.111.suppl_1.a336