Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rejean L. Wang"'
Autor:
Jonathan J. Cho, Zhiwei Xu, Upasana Parthasarathy, Theodore T. Drashansky, Eric Y. Helm, Ashley N. Zuniga, Kyle J. Lorentsen, Samira Mansouri, Joshua Y. Cho, Mariola J. Edelmann, Duc M. Duong, Torben Gehring, Thomas Seeholzer, Daniel Krappmann, Mohammad N. Uddin, Danielle Califano, Rejean L. Wang, Lei Jin, Hongmin Li, Dongwen Lv, Daohong Zhou, Liang Zhou, Dorina Avram
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Ubiquitination may control protein stability or function. Here the authors show that an ubiquitination enzyme, Hectd3, ubiquitinates Stat3 and Malt1 to modulate their function but not degradation in T cells, and thereby promoting the differentiation
Externí odkaz:
https://doaj.org/article/1894c8d823ab4177ab03857c322a339c
Autor:
Nazli Khodayari, Rejean L. Wang, Regina Oshins, Yuanqing Lu, Michael Millett, Alek M. Aranyos, Sayedamin Mostofizadeh, Yogesh Scindia, Tammy O. Flagg, Mark Brantly
Publikováno v:
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13255
International Journal of Molecular Sciences, Vol 22, Iss 13255, p 13255 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 13255, p 13255 (2021)
International Journal of Molecular Sciences
Alpha-1 antitrypsin deficiency (AATD) is caused by a single mutation in the SERPINA1 gene, which culminates in the accumulation of misfolded alpha-1 antitrypsin (ZAAT) within the endoplasmic reticulum (ER) of hepatocytes. AATD is associated with live
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac35887bb6c4776fa57e247145b5bd0
Autor:
Dorina Avram, Rejean L. Wang, Hongmin Li, Upasana Parthasarathy, Torben Gehring, Thomas Seeholzer, Daniel Krappmann, Mohammad N. Uddin, Lei Jin, Liang Zhou, Dongwen Lv, Eric Y. Helm, Jonathan J. Cho, Duc M. Duong, Kyle J. Lorentsen, Theodore T. Drashansky, Danielle Califano, Samira Mansouri, Mariola J. Edelmann, Daohong Zhou, Zhiwei Xu, Joshua Y. Cho, Ashley N. Zuniga
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Nat. Commun. 10:701 (2019)
Nature Communications
Nat. Commun. 10:701 (2019)
Polyubiquitination promotes proteasomal degradation, or signaling and localization, of targeted proteins. Here we show that the E3 ubiquitin ligase Hectd3 is necessary for pathogenic Th17 cell generation in experimental autoimmune encephalomyelitis (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483c070db342678c4ea9656aa2aaf78b
http://link.springer.com/article/10.1038/s41467-019-08605-3
http://link.springer.com/article/10.1038/s41467-019-08605-3
Autor:
Brad E. Hoffman, Farshid N. Rouhani, Mark L. Brantly, George Marek, Nazli Khodayari, Karina Krotova, George Aslanidi, Rejean L. Wang
Alpha-1 antitrypsin (AAT) deficiency-associated emphysema is largely attributed to insufficient inhibition of neutrophil elastase released from neutrophils. Correcting AAT levels using augmentation therapy only slows disease progression, and that sug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a740df2fb9152f338c958878c0b3e2f
https://europepmc.org/articles/PMC5800887/
https://europepmc.org/articles/PMC5800887/
Publikováno v:
Mitochondrion. 11:673
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a47255a7166ab47d442aa2cdc7256dbf
https://doi.org/10.1016/j.mito.2011.03.109
https://doi.org/10.1016/j.mito.2011.03.109