Výsledky vyhledávání - "Rejean Fortin"

Identification of a new biaryl scaffold generating potent renin inhibitors

Autor: Christopher I. Bayly, Dan McKay, Tom Y.-H. Wu, Patrick Roy, Suzanna Liu, Michel Gallant, Austin Chen, Helene Juteau, Rejean Fortin, Daniel Dube, Renee Aspiotis, Patrick Lacombe

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:5822-5826

The discovery and SAR of a series of potent renin inhibitors possessing a novel biaryl scaffold are described herein. Molecular modeling revealed that the cyclopropylamide spacer present in 1 can be replaced by a simple, substituted aromatic ring suc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c8a097e1c75222e7013c703f6e14c4
https://doi.org/10.1016/j.bmcl.2010.07.127

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Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones

Autor: Andre Giroux, Dita M. Rasper, Steven Xanthoudakis, Johanne Renaud, Rejean Fortin, Christophe Mellon, Erich L. Grimm, John P. Vaillancourt, John Tam, Renee Aspiotis, Yongxin Han, Sophie Roy, W. Cameron Black, John Colucci, Paul Tawa, Robert Zamboni, Elise Isabel, Donald W. Nicholson

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 17:1671-1674

Caspase-3 is a cysteinyl protease that mediates apoptotic cell death. Its inhibition may have an important impact on the treatment of several degenerative diseases. Here we report the synthesis of reversible inhibitors via a solid-support palladium-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3ef3107740aa2248fa1a467ca00e24
https://doi.org/10.1016/j.bmcl.2006.12.110

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Influence of the Quench Process on Microstructure Evolution in a Landing Gear Steel

Autor: Rejean Fortin, Mohammad Jahazi, S.M. Chentouf

Publikováno v: Volume 8B: Heat Transfer and Thermal Engineering.

The quench process of large size components is always problematic owing to non-uniform phase formation. In this context, the influence of cooling rate on phase transformation, for different cooling rates, in 300M steel is studied. A combination of hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8fe402face0eebbb492d9955460a6dd
https://doi.org/10.1115/imece2014-38636

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2-Heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors

Autor: Christine Brideau, Richard Friesen, Yves Girard, Chantal Savoie, Chi-Chung Chan, Daniel Dube, Rejean Fortin, Denis Riendeau, Robert Gordon, Denis Deschenes

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 9:1715-1720

A series of novel 2-alkoxy, 2-thioalkoxy and 2-amino-3-(4-methylsulfonyl)phenylpyridines has been synthesized and shown to be highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. Structure-activity relationship studies have demonstrated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99c21cf038edd882ec7006cc31f0fca
https://doi.org/10.1016/s0960-894x(99)00264-4

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2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: Selective and orally active cyclooxygenase-2 inhibitors

Autor: Li Jing Xu, Denise M. Visco, Diane Ethier, Gillian Greig, Denis Riendeau, Jacques Yves Gauthier, Stella Charleson, Chi-Chung Chan, Robert Gordon, Denis Deschenes, Yves Girard, Richard Friesen, Robert N. Young, Elizabeth Wong, Christine Brideau, Chantal Savoie, Daniel Dube, Zhaoyin Wang, Rejean Fortin

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 8:2777-2782

A series of novel 2-pyridinyl-3-(4-methylsulfonyl)phenylpyridines has been synthesized and evaluated with respect to their ability to inhibit the isozymes of cyclooxygenase, COX-1, and COX-2. Optimum COX-2 activity is observed by introduction of a su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e764cce13553e4fd07772ed5c6cbd98
https://doi.org/10.1016/s0960-894x(98)00499-5

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Novel 1,2-diarylcyclobutenes: Selective and orally active cox-2 inhibitors

Autor: Gillian Greig, Richard Friesen, Stacia Kargman, Elizabeth Wong, Wanda Cromlish, Richard Frenette, C. C. Chan, Robert Gordon, Rejean Fortin, Denis Riendeau, Sylvie Prescott, Daniel Dube, Li Jing Xu

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:2677-2682

A series of novel 2,3-diaryl-2-cyclobuten-l-ones have been synthesized and have been evaluated with respect to their ability to inhibit the isozymes of cyclooxygenase, COX-1 and COX-2. 4,4-Dimethyl-2- phenyl-3-(4-(methylsulfonyl)phenyl)cyclobutenone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10aa449126f97fecdbbe91a83de79af2
https://doi.org/10.1016/s0960-894x(96)00501-x

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Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5-Lipoxygenase Inhibitors: Structure−Activity Relationship Study Directed toward the Improvement of Metabolic Stability

Publikováno v: Journal of Medicinal Chemistry. 39:3951-3970

Naphthalenic lignan lactone 3a (L-702,539), a potent and selective 5-lipoxygenase (5-LO) inhibitor, is extensively metabolized at two different sites: the tetrahydropyran and the lactone rings. Early knowledge of the metabolic pathways triggered and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8489d69232985297ecdb5df72fd8f1e7
https://doi.org/10.1021/jm960301c

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New preparation of N(1)- and N(2)- alkylated tetrazoles via displacement of activated alcohols

Autor: Rejean Fortin, Christian Brochu

Publikováno v: Tetrahedron Letters. 35:9681-9684

A facile and convenient synthesis of N(1)- and N(2)-alkyltetrazoles is described. Tetrazole in the presence of zinc triflate reacts smoothly with activated alcohols to give the corresponding alkyltetrazole in high yield.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3178fa94b39f2ae3cb1e8306f739a5a2
https://doi.org/10.1016/0040-4039(94)88358-0

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