Mirror-image ligand discovery enabled by single-shot fast-flow synthesis of D-proteins.

Autor: Callahan AJ; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA., Gandhesiri S; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA., Travaline TL; FOG Pharmaceuticals Inc., 30 Acorn Park Drive, Cambridge, MA, 02140, USA., Reja RM; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA., Lozano Salazar L; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA., Hanna S; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA., Lee YC; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.; Department of Chemistry, National Cheng Kung University, No.1, University Road, Tainan City, 701, Taiwan., Li K; FOG Pharmaceuticals Inc., 30 Acorn Park Drive, Cambridge, MA, 02140, USA., Tokareva OS; FOG Pharmaceuticals Inc., 30 Acorn Park Drive, Cambridge, MA, 02140, USA., Swiecicki JM; FOG Pharmaceuticals Inc., 30 Acorn Park Drive, Cambridge, MA, 02140, USA.; Relay Therapeutics, Inc., 399 Binney Street, 2nd Floor, Cambridge, MA, 02139, USA., Loas A; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA., Verdine GL; FOG Pharmaceuticals Inc., 30 Acorn Park Drive, Cambridge, MA, 02140, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA, 02138, USA.; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138, USA.; Department of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA, 02138, USA., McGee JH; FOG Pharmaceuticals Inc., 30 Acorn Park Drive, Cambridge, MA, 02140, USA. jmcgee@fogpharma.com., Pentelute BL; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA. blp@mit.edu.; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02142, USA. blp@mit.edu.; Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA. blp@mit.edu.; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA. blp@mit.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Feb 28; Vol. 15 (1), pp. 1813. Date of Electronic Publication: 2024 Feb 28.

A cationic amphiphilic peptide chaperone rescues Aβ 42 aggregation and cytotoxicity.

Autor: Puneeth Kumar DR; Department of Chemistry, Indian Institute of Science Education and Research Dr. Homi Bhabha Road, Pashan Pune-411008 India hn.gopi@iiserpune.ac.in., Reja RM; Department of Chemistry, Indian Institute of Science Education and Research Dr. Homi Bhabha Road, Pashan Pune-411008 India hn.gopi@iiserpune.ac.in., Senapati DK; NMR Research Centre, Indian Institute of Science Bangalore-560012 India., Singh M; Department of Chemistry, Indian Institute of Science Education and Research Dr. Homi Bhabha Road, Pashan Pune-411008 India hn.gopi@iiserpune.ac.in., Nalawade SA; Department of Chemistry, Indian Institute of Science Education and Research Dr. Homi Bhabha Road, Pashan Pune-411008 India hn.gopi@iiserpune.ac.in., George G; NMR Research Centre, Indian Institute of Science Bangalore-560012 India., Kaul G; Division of Microbiology and Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute Sitapur Road, Sector 10, Janakipuram Extension Lucknow-226031 Uttar Pradesh India.; AcSIR: Academy of Scientific and Innovative Research (AcSIR) Ghaziabad 201002 India., Akhir A; Division of Microbiology and Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute Sitapur Road, Sector 10, Janakipuram Extension Lucknow-226031 Uttar Pradesh India., Chopra S; Division of Microbiology and Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute Sitapur Road, Sector 10, Janakipuram Extension Lucknow-226031 Uttar Pradesh India.; AcSIR: Academy of Scientific and Innovative Research (AcSIR) Ghaziabad 201002 India., Raghothama S; NMR Research Centre, Indian Institute of Science Bangalore-560012 India., Gopi HN; Department of Chemistry, Indian Institute of Science Education and Research Dr. Homi Bhabha Road, Pashan Pune-411008 India hn.gopi@iiserpune.ac.in.

Publikováno v: RSC medicinal chemistry [RSC Med Chem] 2022 Dec 10; Vol. 14 (2), pp. 332-340. Date of Electronic Publication: 2022 Dec 10 (Print Publication: 2023).

Lysine-Targeting Reversible Covalent Inhibitors with Long Residence Time.

Autor: Reja RM; Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467, United States., Wang W; Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467, United States., Lyu Y; Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467, United States., Haeffner F; Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467, United States., Gao J; Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2022 Jan 26; Vol. 144 (3), pp. 1152-1157. Date of Electronic Publication: 2022 Jan 18.

Structural insight into hybrid peptide ε-helices.

Autor: Misra R; Department of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411021, India. hn.gopi@iiserpune.ac.in., George G; NMR Research Center, Indian Institute of Science, Bangalore-560012, India. sr@nic.iisc.ernet.in., Reja RM; Department of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411021, India. hn.gopi@iiserpune.ac.in., Dey S; Department of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411021, India. hn.gopi@iiserpune.ac.in., Raghothama S; NMR Research Center, Indian Institute of Science, Bangalore-560012, India. sr@nic.iisc.ernet.in., Gopi HN; Department of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411021, India. hn.gopi@iiserpune.ac.in.

Publikováno v: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Feb 18; Vol. 56 (14), pp. 2171-2173. Date of Electronic Publication: 2020 Jan 23.

Artificial β-Double Helices from Achiral γ-Peptides.

Autor: Misra R; Department of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-, 411 008, India., Dey S; Department of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-, 411 008, India., Reja RM; Department of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-, 411 008, India., Gopi HN; Department of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-, 411 008, India.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2018 Jan 22; Vol. 57 (4), pp. 1057-1061. Date of Electronic Publication: 2017 Dec 27.